Crystal Structure of the Atypical Protein Kinase Domain of a TRP Channel with Phosphotransferase Activity

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

1992 • 3,488 citations

[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods

1997 • 1,905 citations

Dali: a network tool for protein structure comparison

1995 • 1,447 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransduction

1989 • 1,119 citations

Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

1991 • 949 citations

Efficient anisotropic refinement of macromolecular structures using FFT

1999 • 943 citations

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

1997 • 929 citations

The Three-Dimensional Structure of Peptide-MHC Complexes

1995 • 817 citations

Crystallographic Analysis of the Recognition of a Nuclear Localization Signal by the Nuclear Import Factor Karyopherin α

1998 • 759 citations

3D domain swapping: A mechanism for oligomer assembly

1995 • 749 citations

TRP-PLIK, a Bifunctional Protein with Kinase and Ion Channel Activities

2001 • 714 citations

From worm to man: three subfamilies of TRP channels

2000 • 490 citations

Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).

1993 • 399 citations

Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis.

1998 • 398 citations

Receptor-activated Ca2+ inflow in animal cells: a variety of pathways tailored to meet different intracellular Ca2+ signalling requirements

1999 • 295 citations

Release of Proteins and Peptides from Fusion Proteins Using a Recombinant Plant Virus Proteinase

1994 • 282 citations

Crystal Structure of a Phosphatidylinositol 3-Phosphate-Specific Membrane-Targeting Motif, the FYVE Domain of Vps27p

1999 • 257 citations

Structure of an Enzyme Required for Aminoglycoside Antibiotic Resistance Reveals Homology to Eukaryotic Protein Kinases

1997 • 235 citations

Structure of Type IIβ Phosphatidylinositol Phosphate Kinase

1998 • 214 citations

The structural basis for substrate recognition and control by protein kinases¹

1998 • 204 citations

Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase

1997 • 200 citations

Signal Transduction in Drosophila Photoreceptors

1995 • 178 citations

Crystal Structure of the VHS and FYVE Tandem Domains of Hrs, a Protein Involved in Membrane Trafficking and Signal Transduction

2000 • 164 citations

Mutation of Position 52 in ERK2 Creates a Nonproductive Binding Mode for Adenosine 5‘-Triphosphate^,

1996 • 136 citations

1 Modulation of ion channels by protein phosphorylation

1999 • 135 citations

Phosphoinositide-mediated phototransduction in Drosophila photoreceptors: the role of Ca2+ and trp

1995 • 119 citations

Receptor-activated Ca2+ inflow in animal cells: a variety of pathways tailored to meet different intracellular Ca2+ signalling requirements

1999 • 80 citations

Cloning and Expression of cDNA Encoding Protein Synthesis Elongation Factor-2 Kinase

1996 • 71 citations

A novel type of protein kinase phosphorylates actin in the actin-fragmin complex.

1996 • 69 citations

Novel compounds, ‘1,3-selenazine derivatives’ as specific inhibitors of eukaryotic elongation factor-2 kinase

2000 • 60 citations

Mapping of the Novel Protein Kinase Catalytic Domain of Dictyostelium Myosin II Heavy Chain Kinase A

1997 • 58 citations

Analysis of the domain structure of elongation factor‐2 kinase by mutagenesis

1999 • 55 citations

ADP-Binding Site of Escherichia coli Succinyl-CoA Synthetase Revealed by X-ray Crystallography^,

1999 • 53 citations

The structure of SAICAR synthase: an enzyme in the de novo pathway of purine nucleotide biosynthesis

1998 • 48 citations

Phosphatidylinositol Phosphate Kinase: A Link between Protein Kinase and Glutathione Synthase Folds

1999 • 46 citations

The crystal structure of the Physarum polycephalum actin-fragmin kinase: an atypical protein kinase with a specialized substrate-binding domain

1999 • 36 citations

Two “unrelated” families of ATP‐dependent enzymes share extensive structural similarities about their cofactor binding sites

1998 • 22 citations