Cloning and Expression of a Novel Mammalian Homolog ofDrosophila Transient Receptor Potential (Trp) Involved in Calcium Entry Secondary to Activation of Receptors Coupled by the Gq Class of G Protein

Molecular cloning: A laboratory manual

1990 • 85,659 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Genomic sequencing.

1984 • 8,343 citations

Antibodies: A laboratory manual

1989 • 4,532 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Muscarinic activation of ionic currents measured by a new whole-cell recording method.

1988 • 1,777 citations

Depletion of intracellular calcium stores activates a calcium current in mast cells

1992 • 1,748 citations

Capacitative calcium entry revisited

1990 • 1,499 citations

Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransduction

1989 • 1,119 citations

Capacitative calcium entry

1995 • 1,112 citations

Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx

1993 • 892 citations

SK&F 96365, a novel inhibitor of receptor-mediated calcium entry

1990 • 762 citations

The trp gene is essential for a light-activated Ca2+ channel in Drosophila photoreceptors

1992 • 732 citations

Calcium release‐activated calcium current in rat mast cells.

1993 • 729 citations

trp, a Novel Mammalian Gene Family Essential for Agonist-Activated Capacitative Ca2+ Entry

1996 • 688 citations

TRPC1, a human homolog of a Drosophila store-operated channel.

1995 • 623 citations

Simultaneous inhibitions of inositol phospholipid breakdown, arachidonic acid release, and histamine secretion in mast cells by islet-activating protein, pertussis toxin. A possible involvement of the toxin-specific substrate in the Ca2+-mobilizing receptor-mediated biosignaling system.

1985 • 509 citations

The Inositol Phosphate-Calcium Signaling System in Nonexcitable Cells

1993 • 505 citations

Identification of a Drosophila gene encoding a calmodulin-binding protein with homology to the trp phototransduction gene

1992 • 441 citations

Receptor-activated Ca2+ influx: how many mechanisms for how many channels?

1994 • 403 citations

Cloning and Functional Expression of a Human Ca2+-Permeable Cation Channel Activated by Calcium Store Depletion

1996 • 391 citations

On the molecular basis and regulation of cellular capacitative calcium entry: Roles for Trp proteins

1996 • 378 citations

Evidence for dual coupling of the murine luteinizing hormone receptor to adenylyl cyclase and phosphoinositide breakdown and Ca2+ mobilization. Studies with the cloned murine luteinizing hormone receptor expressed in L cells.

1992 • 371 citations

The Drosophila Light-Activated Conductance Is Composed of the Two Channels TRP and TRPL

1996 • 368 citations

Depletion of InsP3 stores activates a Ca2+ and K+ current by means of a phosphatase and a diffusible messenger

1993 • 363 citations

Molecular cloning of a widely expressed human homologue for the Drosophila trp gene

1995 • 351 citations

Coassembly of TRP and TRPL Produces a Distinct Store-Operated Conductance

1997 • 310 citations

A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL.

1996 • 286 citations

Novel Ca2+ channels underlying transduction in Drosophila photoreceptors: implications for phosphoinositide-mediated Ca2+ mobilization

1993 • 262 citations

The calcium current activated by T cell receptor and store depletion in human lymphocytes is absent in a primary immunodeficiency.

1994 • 256 citations

Histochemical staining of clonal mammalian cell lines expressingE. coli ? galactosidase indicates heterogeneous expression of the bacterial gene

1987 • 232 citations

Activation of recombinant trp by thapsigargin in Sf9 insect cells

1994 • 226 citations

Putative capacitative calcium entry channels: expression of Drosophila trp and evidence for the existence of vertebrate homologues

1995 • 193 citations

The biology of vision of Drosophila.

1996 • 192 citations

Thyrotropin-releasing hormone-induced spike and plateau in cytosolic free Ca2+ concentrations in pituitary cells. Relation to prolactin release.

1984 • 192 citations

ADP- and thapsigargin-evoked Ca2+ entry and protein-tyrosine phosphorylation are inhibited by the tyrosine kinase inhibitors genistein and methyl-2,5-dihydroxycinnamate in fura-2-loaded human platelets.

1993 • 191 citations

Inhibition of thapsigargin-induced calcium entry by microinjected guanine nucleotide analogues. Evidence for the involvement of a small G-protein in capacitative calcium entry.

1993 • 183 citations

Molecular cloning and expression of a fifth muscarinic acetylcholine receptor

1989 • 182 citations

A primary T-cell immunodeficiency associated with defective transmembrane calcium influx

1995 • 174 citations

Capacitative Ca 2+ Entry Exclusively Inhibits cAMP Synthesis in C6-2B Glioma Cells

1995 • 163 citations

Ca2+ and Mn2+ influx through receptor-mediated activation of nonspecific cation channels in mast cells.

1993 • 154 citations

Arachidonic Acid Activates the Noncapacitative Entry of Ca2+ during [Ca2+] Oscillations

1996 • 151 citations

The agonist-sensitive calcium pool in the pancreatic acinar cell. Activation of plasma membrane Ca2+ influx mechanism.

1987 • 142 citations

The light response of drosophila photoreceptors is accompanied by an increase in cellular calcium: Effects of specific mutations

1994 • 137 citations

Cyclic GMP modulates depletion-activated Ca2+ entry in pancreatic acinar cells

1993 • 130 citations

Phosphoinositide-mediated phototransduction in Drosophila photoreceptors: the role of Ca2+ and trp

1995 • 119 citations

Coexpression of Drosophila TRP and TRP-like proteins in Xenopus oocytes reconstitutes capacitative Ca ²⁺ entry

1996 • 105 citations

The route of Ca2+ entry during reloading of the intracellular Ca2+ pool in pancreatic acini.

1990 • 104 citations

Epidermal growth factor-activated calcium and potassium channels.

1991 • 97 citations

Capacitative Ca2+ entry regulates Ca2+-sensitive adenylyl cyclases

1994 • 82 citations

A fully active nonglycosylated V2 vasopressin receptor.

1996 • 82 citations

Role of the capacitative calcium influx in the activation of steroidogenesis by angiotensin-II in adrenal glomerulosa cells.

1994 • 76 citations

The alpha 2A-adrenergic receptor is targeted directly to the basolateral membrane domain of Madin-Darby canine kidney cells independent of coupling to pertussis toxin-sensitive GTP-binding proteins

1993 • 71 citations

Direct activation of trpl cation channels by G alpha11 subunits.

1996 • 68 citations

Ins(1,4,5)P3 activates Drosophila cation channel Trpl in recombinant baculovirus-infected Sf9 insect cells

1995 • 63 citations

Mechanisms and genetics of photoreceptors desensitization in Drosophila flies

1993 • 55 citations

Cellular responses to stimulation of the M5 muscarinic acetylcholine receptor as seen in murine L cells.

1990 • 49 citations

Arachidonate mobilization is coupled to depletion of intracellular calcium stores and influx of extracellular calcium in differentiated U937 cells

1996 • 39 citations

Calcium Signalling: Cracking ICRAC in the eye

1995 • 37 citations

Cloning and expression localization of cDNA for rat homolog of TRP protein, a possible store-operated calcium (Ca2+) channel

1996 • 36 citations

A slowly ADP-ribosylated pertussis-toxin-sensitive GTP-binding regulatory protein is required for vasopressin-stimulated Ca2+ inflow in hepatocytes

1994 • 34 citations

Phosphatase inhibitors suppress Ca2+ influx induced by receptor-mediated intracellular Ca2+ store depletion in human platelets

1994 • 32 citations

Chemical excitation and inactivation in photoreceptors of the fly mutants trp and nss.

1989 • 29 citations

Receptor-mediated Mn2+ influx in rat hepatocytes: comparison of cells loaded with Fura-2 ester and cells microinjected with Fura-2 salt

1994 • 29 citations

Two independently regulated Ca2+ entry mechanisms coexist in Jurkat T cells during T cell receptor antigen activation

1993 • 22 citations

Control of Ca2+ entry into rat lactotrophs by thyrotrophin‐releasing hormone.

1995 • 18 citations