Mitogen-induced oscillations of cytosolic Ca2+ and transmembrane Ca2+ current in human leukemic T cells.

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Down-Regulation of Na⁺/K⁺ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

2013 • 8,607 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Regulation of the Voltage Gated K<sup>+</sup> Channel K<sub>v1.3</sub> by Recombinant Human Klotho Protein

2014 • 5,592 citations

Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

1983 • 2,596 citations

A model for receptor-regulated calcium entry

1986 • 2,535 citations

Muscarinic activation of ionic currents measured by a new whole-cell recording method.

1988 • 1,777 citations

Calcium Channel

1981 • 1,184 citations

T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes

1982 • 1,026 citations

Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

1985 • 753 citations

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

1985 • 742 citations

Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis?

1984 • 734 citations

Ion channels activated by inositol 1,4,5-trisphosphate in plasma membrane of human T-lymphocytes

1987 • 676 citations

Solubilization, purification, and characterization of an inositol trisphosphate receptor.

1988 • 650 citations

Regulation of calcium influx by second messengers in rat mast cells

1988 • 506 citations

Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration

1986 • 489 citations

A common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cells

1985 • 456 citations

Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium.

1984 • 452 citations

Phorbol ester and sperm activate mouse oocytes by inducing sustained oscillations in cell Ca2+

1985 • 434 citations

Fura-2 measurement of cytosolic free Ca2+ in monolayers and suspensions of various types of animal cells.

1987 • 424 citations

Inositol trisphosphate and diacylglycerol as intracellular second messengers in liver

1985 • 419 citations

Molecular model for receptor-stimulated calcium spiking.

1988 • 416 citations

Repetitive spikes in cytoplasmic calcium evoked by histamine in human endothelial cells

1988 • 412 citations

A voltage‐gated potassium channel in human T lymphocytes.

1985 • 403 citations

Myoplasmic binding of fura-2 investigated by steady-state fluorescence and absorbance measurements

1988 • 362 citations

The Ca signal from fura‐2 loaded mast cells depends strongly on the method of dye‐loading

1985 • 356 citations

K channels in T lymphocytes: a patch clamp study using monoclonal antibody adhesion

1984 • 308 citations

Temporal and spatial dynamics of the periodic increase in intracellular free calcium at fertilization of golden hamster eggs

1986 • 308 citations

Highly Cooperative Opening of Calcium Channels by Inositol 1,4,5-Trisphosphate

1988 • 307 citations

Agonists stimulate divalent cation channels in the plasma membrane of human platelets

1985 • 303 citations

Cell Surface Molecules and Early Events Involved in Human T Lymphocyte Activation

1987 • 297 citations

Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx

1985 • 282 citations

Spatial and temporal aspects of cell signalling

1988 • 278 citations

Agonist-induced oscillations in cytoplasmic free calcium concentration in single rat hepatocytes

1987 • 271 citations

Regulation of cytosolic free calcium in fura-2-loaded rat parotid acinar cells.

1987 • 245 citations

Calcium dependency of antigen-specific (T3-Ti) and alternative (T11) pathways of human T-cell activation.

1984 • 175 citations

Second messenger‐activated calcium influx in rat peritoneal mast cells.

1989 • 163 citations

Single-channel and whole-cell recordings of mitogen-regulated inward currents in human cloned helper T lymphocytes

1986 • 151 citations

Requirement for calcium ions in lymphocyte transformation stimulated by phytohemagglutinin

1972 • 151 citations

The localization of calcium release by inositol trisphosphate in Limulus photoreceptors and its control by negative feedback

1988 • 138 citations

Calcium channels in thrombin-activated human platelet membrane

1988 • 136 citations

Role of membrane potential in the regulation of lectin‐induced calcium uptake

1984 • 121 citations

Calcium‐dependent activation of lymphocytes by ionophore, A23187, and a phorbol ester tumor promoter

1983 • 120 citations

Cross-linking of surface immunoglobulin on B lymphocytes induces both intracellular Ca2+ release and Ca2+ influx: Analysis with indo-1

1986 • 112 citations

Agonist-stimulated oscillations and cycling of intracellular free calcium in individual cultured muscle cells.

1988 • 105 citations

Fast calcium transients in rat peritoneal mast cells are not sufficient to trigger exocytosis.

1986 • 104 citations

T-Cell Activation

1986 • 102 citations

Potassium current in clonal cytotoxic T lymphocytes from the mouse.

1984 • 101 citations

Antigen-dependent increase in cytosolic free calcium in specific human T-lymphocyte clones

1985 • 92 citations

Distinct patterns of transmembrane calcium flux and intracellular calcium mobilization after differentiation antigen cluster 2 (E rosette receptor) or 3 (T3) stimulation of human lymphocytes.

1986 • 89 citations

The T-cell antigen receptor regulates sustained increases in cytoplasmic free Ca2+ through extracellular Ca2+ influx and ongoing intracellular Ca2+ mobilization

1987 • 87 citations

Characterization of the role for calcium influx in mitogen‐induced triggering of human T cells. Identification of calcium‐dependent and calcium‐independent signals

1986 • 86 citations

Crosslinkage of B lymphocyte surface immunoglobulin by anti-Ig or antigen induces prolonged oscillation of intracellular ionized calcium.

1987 • 82 citations

Calcium and inositolphosphates in the activation of T cell-mediated cytotoxicity.

1987 • 72 citations

Dependence of intracellular effects of GTPγS and inositoltrisphosphate on cell membrane potential and on external Ca ions

1987 • 63 citations

Initial Characterization of the Calcium Channel Activated by the Crosslinking of the Receptors for Immunoglobulin E *

1986 • 55 citations

Heterogeneity of lymphocyte calcium metabolism is caused by T cell-specific calcium-sensitive potassium channel and sensitivity of the calcium ATPase pump to membrane potential.

1988 • 51 citations

Detection of ligand-activated conductive Ca2+ channels in human B lymphocystephen

1988 • 49 citations

Triggering of T-lymphocytes via Either T3-Ti or T11 Surface Structures Opens a Voltage-insensitive Plasma Membrane Calcium-permeable Channel: Requirement for Interleukin-2 Gene Function

1989 • 46 citations

Initial characterization of the calcium channel activated by the cross-linking of the receptors for immunoglobulin E.

1984 • 41 citations

Spatial and temporal characteristics of the increase in intracellular Ca2+ induced in cytotoxic T lymphocytes by cellular antigen.

1988 • 38 citations