12 Store-operated calcium channels

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Ionic Channels of Excitable Membranes

1985 • 3,014 citations

Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

1983 • 2,596 citations

A model for receptor-regulated calcium entry

1986 • 2,535 citations

Calcium signaling

1995 • 1,905 citations

Depletion of intracellular calcium stores activates a calcium current in mast cells

1992 • 1,748 citations

Capacitative calcium entry revisited

1990 • 1,499 citations

Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps.

1991 • 1,282 citations

Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransduction

1989 • 1,119 citations

Capacitative calcium entry

1995 • 1,112 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx

1993 • 892 citations

Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores.

1993 • 752 citations

‘Quanta’ Ca²⁺ release and the control of Ca²⁺ entry by inositol phosphates ‐ a possible mechanism

1990 • 743 citations

The trp gene is essential for a light-activated Ca2+ channel in Drosophila photoreceptors

1992 • 732 citations

Calcium release‐activated calcium current in rat mast cells.

1993 • 729 citations

trp, a Novel Mammalian Gene Family Essential for Agonist-Activated Capacitative Ca2+ Entry

1996 • 688 citations

TRPC1, a human homolog of a Drosophila store-operated channel.

1995 • 623 citations

Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels

1993 • 614 citations

CONDUCTANCE FLUCTUATIONS AND IONIC PORES IN MEMBRANES

1977 • 510 citations

Regulation of calcium influx by second messengers in rat mast cells

1988 • 506 citations

The Inositol Phosphate-Calcium Signaling System in Nonexcitable Cells

1993 • 505 citations

Potassium and Calcium Channels in Lymphocytes

1995 • 488 citations

Identification of a Drosophila gene encoding a calmodulin-binding protein with homology to the trp phototransduction gene

1992 • 441 citations

Receptor-activated Ca2+ influx: how many mechanisms for how many channels?

1994 • 403 citations

Mitogen-induced oscillations of cytosolic Ca2+ and transmembrane Ca2+ current in human leukemic T cells.

1989 • 402 citations

Cloning and Functional Expression of a Human Ca2+-Permeable Cation Channel Activated by Calcium Store Depletion

1996 • 391 citations

Rapid inactivation of depletion-activated calcium current (ICRAC) due to local calcium feedback.

1995 • 370 citations

The Drosophila Light-Activated Conductance Is Composed of the Two Channels TRP and TRPL

1996 • 368 citations

The use of fura-2 for estimating ca buffers and ca fluxes

1995 • 364 citations

Molecular cloning of a widely expressed human homologue for the Drosophila trp gene

1995 • 351 citations

The mechanism of the calcium signal and correlation with histamine release in 2H3 cells.

1984 • 351 citations

Requirement for the PDZ Domain Protein, INAD, for Localization of the TRP Store-Operated Channel to a Signaling Complex

1997 • 292 citations

A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL.

1996 • 286 citations

A GTP-dependent step in the activation mechanism of capacitative calcium influx.

1993 • 283 citations

Overexpression of Calreticulin Increases Intracellular Ca2+ Storage and Decreases Store-operated Ca2+ Influx

1996 • 266 citations

The calcium current activated by T cell receptor and store depletion in human lymphocytes is absent in a primary immunodeficiency.

1994 • 256 citations

Slow Calcium-dependent Inactivation of Depletion-activated Calcium Current. STORE-DEPENDENT AND -INDEPENDENT MECHANISMS

1995 • 234 citations

Calreticulin inhibits repetitive intracellular Ca2+ waves

1995 • 233 citations

Activation of recombinant trp by thapsigargin in Sf9 insect cells

1994 • 226 citations

The transient receptor potential protein (Trp), a putative store-operated Ca2+ channel essential for phosphoinositide-mediated photoreception, forms a signaling complex with NorpA, InaC and InaD.

1996 • 212 citations

Concentration Profiles of Intracellular Calcium in the Presence of a Diffusible Chelator

1986 • 196 citations

Putative capacitative calcium entry channels: expression of Drosophila trp and evidence for the existence of vertebrate homologues

1995 • 193 citations

Ca2+ influx following receptor activation

1991 • 187 citations

Inhibition of thapsigargin-induced calcium entry by microinjected guanine nucleotide analogues. Evidence for the involvement of a small G-protein in capacitative calcium entry.

1993 • 183 citations

Signaling between intracellular Ca2+ stores and depletion-activated Ca2+ channels generates [Ca2+]i oscillations in T lymphocytes.

1994 • 181 citations

Depletion of intracellular Ca2+ stores activates nitric-oxide synthase to generate cGMP and regulate Ca2+ influx.

1994 • 179 citations

Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels.

1995 • 179 citations

A primary T-cell immunodeficiency associated with defective transmembrane calcium influx

1995 • 174 citations

Calcium influx and its control by calcium release

1993 • 167 citations

Depletion-activated calcium current is inhibited by protein kinase in RBL-2H3 cells.

1995 • 166 citations

Non-specific effects of calcium entry antagonists in mast cells

1994 • 164 citations

Cytochrome P-450 may link intracellular Ca2+ stores with plasma membrane Ca2+ influx

1991 • 164 citations

Structural determinants of ion selectivity in brain calcium channel

1993 • 147 citations

Depletion of intracellular Ca2+ stores activates a Ca(2+)-selective channel in vascular endothelium

1994 • 146 citations

Cytosolic calcium transients: Spatial localization and role in drosophila photoreceptor cell function

1994 • 143 citations

Cyclic GMP mediates the agonist-stimulated increase in plasma membrane calcium entry in the pancreatic acinar cell.

1990 • 138 citations

Calcium-dependent potentiation of store-operated calcium channels in T lymphocytes.

1996 • 137 citations

Depolarization of rat basophilic leukemia cells inhibits calcium uptake and exocytosis.

1987 • 132 citations

Calcium channels activated by depletion of internal calcium stores in A431 cells

1994 • 131 citations

Cyclic GMP modulates depletion-activated Ca2+ entry in pancreatic acinar cells

1993 • 130 citations

Conductance and permeation of monovalent cations through depletion-activated Ca2+ channels (ICRAC) in Jurkat T cells

1996 • 124 citations

Calcium and barium permeation through calcium release-activated calcium (CRAC) channels

1995 • 123 citations

Activation of Ca2+ current in Jurkat T cells following the depletion of Ca2+ stores by microsomal Ca(2+)-ATPase inhibitors.

1994 • 123 citations

Phosphoinositide-mediated phototransduction in Drosophila photoreceptors: the role of Ca2+ and trp

1995 • 119 citations

Flash photolysis of caged inositol 1,4,5-trisphosphate activates plasma membrane calcium current in human T cells.

1993 • 112 citations

Inhibition by SK&F 96365 of Ca²⁺ current, IL‐2 production and activation in T lymphocytes

1994 • 111 citations

Depletion of intracellular Ca2+ stores activates a maitotoxin-sensitive nonselective cationic current in beta-cells.

1994 • 108 citations

Ca²⁺ influx in human T lymphocytes is induced independently of inositol phosphate production by mobilization of intracellular Ca²⁺ stores. A study with the Ca²⁺ endoplasmic reticulum‐ATPase inhibitor thapsigargin

1990 • 106 citations

Activation of calcium oscillations by thapsigargin in parotid acinar cells.

1991 • 106 citations

Coexpression of Drosophila TRP and TRP-like proteins in Xenopus oocytes reconstitutes capacitative Ca ²⁺ entry

1996 • 105 citations

Depletion of Intracellular Calcium Stores Activates a Calcium Conducting Nonselective Cation Current in Mouse Pancreatic Acinar Cells

1996 • 104 citations

Primaquine, an inhibitor of vesicular transport, blocks the calcium-release-activated current in rat megakaryocytes

1995 • 94 citations

Activation of different Cl currents in Xenopus oocytes by Ca liberated from stores and by capacitative Ca influx.

1996 • 93 citations

Modulation of Ca2+ influx dependent on store depletion by intracellular adenine-guanine nucleotide levels.

1994 • 87 citations

Evaluation of Calcium Influx Factors from Stimulated Jurkat T-lymphocytes by Microinjection into Xenopus Oocytes

1995 • 86 citations

IP3-activated Ca2+ channels in the plasma membrane of cultured vascular endothelial cells

1995 • 85 citations

The role of intracellular Ca2+ in the regulation of the plasma membrane Ca2+ permeability of unstimulated rat lymphocytes

1991 • 82 citations

TRP Is Cracked but Is CRAC TRP?

1996 • 82 citations

Unitary cardiac Na+, Ca2+ exchange current magnitudes determined from channel-like noise and charge movements of ion transport

1996 • 73 citations

Single channel recording

1996 • 72 citations

Expression of inositol 1,4,5-trisphosphate receptors changes the Ca2+ signal of Xenopus oocytes

1996 • 68 citations

Antigen and thapsigargin promote influx of Ca2+ in rat basophilic RBL-2H3 cells by ostensibly similar mechanisms that allow filling of inositol 1,4,5-trisphosphate-sensitive and mitochondrial Ca2+ stores

1994 • 67 citations

The COOH-terminal Domain of Drosophila TRP Channels Confers Thapsigargin Sensitivity

1996 • 65 citations

Multiple mechanisms of manganese-induced quenching of fura-2 fluorescence in rat mast cells

1993 • 64 citations

The regulation of store-dependent Ca2+ influx in HL-60 granulocytes involves GTP-sensitive elements.

1993 • 63 citations

Voltage-independent calcium channels

1994 • 61 citations

Three cation influx currents activated by purinergic receptor stimulation in rat megakaryocytes.

1994 • 61 citations

Immunoglobulin E receptor‐activated calcium conductance in rat mast cells.

1995 • 60 citations

Capacitative calcium entry is colocalised with calcium release in Xenopus oocytes: Evidence against a highly diffusible calcium influx factor

1996 • 58 citations

Kinetics of empty store-activated Ca2+ influx in HeLa cells.

1994 • 55 citations

Chromatographic Resolution of an Intracellular Calcium Influx Factor from Thapsigargin-activated Jurkat Cells

1995 • 51 citations

ATP depletion inhibits capacitative Ca2+ entry in rat thymic lymphocytes

1995 • 50 citations

Calcium current activated by muscarinic receptors and thapsigargin in neuronal cells.

1994 • 48 citations

The nitric oxide/cGMP pathway couples muscarinic receptors to the activation of Ca2+ influx

1996 • 46 citations

TRP: Its Role in Phototransduction and Store-Operated Ca2+ Entry

1996 • 46 citations

Extracellular pH modulates the Ca2+ current activated by depletion of intracellular Ca2+ stores in human macrophages

1995 • 46 citations

Excitation of Drosophila photo-receptors by BAPTA and ionomycin: evidence for capacitative Ca2+ entry?

1996 • 46 citations

Ca2+ influx induced by store release and cytosolic Ca2+ chelation in HT29 colonic carcinoma cells

1995 • 44 citations

[Ca2+]i inhibition of Ca2+ release-activated Ca2+ influx underlies agonist- and thapsigargin-induced [Ca2+]i oscillations in salivary acinar cells.

1994 • 42 citations

Calcium influx and intracellular calcium release in anti-CD3 antibody-stimulated and thapsigargin-treated human T lymphoblasts

1991 • 41 citations

Calcium-dependent Enhancement of Depletion-activated Calcium Current in Jurkat T Lymphocytes

1996 • 40 citations

The Ca2+-mobilizing Actions of a Jurkat Cell Extract on Mammalian Cells and Xenopus laevis Oocytes

1995 • 40 citations

A highly calcium‐selective cation current activated by intracellular calcium release in MDCK cells.

1995 • 39 citations

Calcium Signalling: Cracking ICRAC in the eye

1995 • 37 citations

Role of cyclic GMP in the control of capacitative Ca2+ entry in rat pancreatic acinar cells

1995 • 36 citations

Store-operated Ca2+ influx: What is the message from the stores to the membrane?

1996 • 36 citations

Organellar Ion Channels and Transporters

2017 • 34 citations

Extracellular site for econazole‐mediated block of Ca²⁺ release‐activated Ca²⁺ current (I_crac) in T lymphocytes

1996 • 33 citations

Calmodulin inhibits calcium influx current in vascular endothelium

1996 • 31 citations

The relationship between depletion of intracellular Ca2+ stores and activation of Ca2+ current by muscarinic receptors in neuroblastoma cells.

1995 • 29 citations

Regulation of inositol trisphosphate-induced membrane currents in Xenopus oocytes by a Jurkat cell calcium influx factor

1996 • 28 citations

Calcium requirement for cGMP production during muscarinic activation of N1E-115 neuroblastoma cells

1995 • 26 citations

Hormone-regulated Ca2+ channel in rat hepatocytes revealed by whole cell patch clamp

1995 • 24 citations

Intracellular ADP Modulates the Ca Release-activated Ca Current in a Temperature- and Ca -dependent Way

1996 • 23 citations

A voltage-operable current is involved in Ca2+ entry in human lymphocytes whereas ICRAC has no apparent role

1996 • 22 citations

cGMP is not required for capacitative Ca2+ entry in Jurkat T-lymphocytes

1996 • 17 citations

Evidence for a Phorbol Ester-insensitive Phosphorylation Step in Capacitative Calcium Entry in Rat Thymic Lymphocytes

1996 • 15 citations

A Ca 2+ Current Activated by Release of Intracellular Ca 2+ Stores in Rat Basophilic Leukemia Cells (RBL-1)

1996 • 12 citations

Temperature-dependent Block of Capacitative Ca2+ Influx in the Human Leukemic Cell Line KU-812

1996 • 11 citations