Tumor necrosis factor alpha induces apoptosis in mammary adenocarcinoma cells by an increase in intranuclear free Ca2+ concentration and DNA fragmentation.

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Programmed cell death involved in the schizolysigenous formation of the secretory cavity in Citrus sinensis L. (Osbeck)

2010 • 1,629 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.

1988 • 889 citations

Calcium gradients in single smooth muscle cells revealed by the digital imaging microscope using Fura-2

1985 • 660 citations

Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

1983 • 616 citations

Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration

1989 • 549 citations

Calcium‐activated DNA fragmentation kills immature thymocytes

1989 • 533 citations

Cachectin/tumor necrosis factor exerts endocrine, paracrine, and autocrine control of inflammatory responses.

1988 • 441 citations

Cell death in biology and pathology

1981 • 290 citations

ATP stimulates Ca2+ uptake and increases the free Ca2+ concentration in isolated rat liver nuclei.

1989 • 284 citations

Calcium-activated DNA Fragmentation in Rat Liver Nuclei

1989 • 281 citations

Use of aurintricarboxylic acid as an inhibitor of nucleases during nucleic acid isolation

1977 • 280 citations

Inhibition of DNA Fragmentation in Thymocytes and Isolated Thymocyte Nuclei by Agents That Stimulate Protein Kinase C

1989 • 276 citations

Cytotoxic T lymphocytes and glucocorticoids activate an endogenous suicide process in target cells

1987 • 201 citations

Tributyltin stimulates apoptosis in rat thymocytes

1990 • 187 citations

Regional Changes in Calcium Underlying Contraction of Single Smooth Muscle Cells

1987 • 179 citations

An inositol 1,4,5-trisphosphate-sensitive Ca2+ pool in liver nuclei.

1990 • 165 citations

Interleukin 1 inhibits T cell receptor-mediated apoptosis in immature thymocytes.

1990 • 125 citations

Differences in target cell DNA fragmentation induced by mouse cytotoxic T lymphocytes and natural killer cells.

1986 • 102 citations

Calcium‐dependent DNA fragmentation in human synovial cells exposed to cold shock

1990 • 82 citations

Tumor necrosis factor induces synthesis of two proteins in human fibroblasts.

1986 • 65 citations

Three-dimensional intracellular calcium gradients in single human burst-forming units-erythroid-derived erythroblasts induced by erythropoietin.

1990 • 48 citations