The potential roles of p53 tumor suppressor in nucleotide excision repair (NER) and base excision repair (BER)

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

1995 • 1,500 citations

The p53 pathway

1999 • 1,322 citations

The complexity of p53 modulation: emerging patterns from divergent signals

1998 • 1,319 citations

Post‐translational modifications and activation of p53 by genotoxic stresses

2001 • 1,076 citations

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

2003 • 735 citations

Regulation and function of the p53 tumor suppressor protein

2001 • 716 citations

Apoptosis, p53, and tumor cell sensitivity to anticancer agents.

1999 • 708 citations

SUMO-1 modification activates the transcriptional response of p53

1999 • 627 citations

Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair

1999 • 571 citations

Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1

1999 • 507 citations

Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.

1995 • 491 citations

Identification of redox/repair protein Ref-1 as a potent activator of p53.

1997 • 479 citations

Thioredoxin-dependent Redox Regulation of p53-mediated p21 Activation

1999 • 433 citations

p53-Mediated DNA Repair Responses to UV Radiation: Studies of Mouse Cells Lacking p53, p21, and/orgadd45 Genes

2000 • 422 citations

p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.

1994 • 410 citations

Passing the baton in base excision repair.

2000 • 338 citations

A role for p53 in base excision repair

2001 • 332 citations

Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents.

1996 • 298 citations

Selenomethionine regulation of p53 by a ref1-dependent redox mechanism

2002 • 285 citations

Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo

1999 • 241 citations

Mechanisms of switching on p53: a role for covalent modification?

1999 • 236 citations

GADD45-induced cell cycle G2-M arrest associates with altered subcellular distribution of cyclin B1 and is independent of p38 kinase activity

2002 • 197 citations

p53 tagged sites from human genomic DNA

1994 • 178 citations

Reconstitution of Proliferating Cell Nuclear Antigen-dependent Repair of Apurinic/Apyrimidinic Sites with Purified Human Proteins

1999 • 177 citations

Functional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations.

1996 • 172 citations

Genotoxic and non-genotoxic pathways of p53 induction

2001 • 167 citations

Dimethylbenzanthracene carcinogenesis in Gadd45a-null mice is associated with decreased DNA repair and increased mutation frequency.

2001 • 107 citations

p53 modulates base excision repair activity in a cell cycle-specific manner after genotoxic stress.

2001 • 102 citations

Reinvestigation of the Classification of Five Cell Strains of Xeroderma Pigmentosum Group E with Reclassification of Three of Them

2000 • 74 citations

Association of the XRCC1 gene polymorphisms with cancer risk in Turkish breast cancer patients

2004 • 54 citations

Nucleotide excision repair in the yeast Saccharomyces cerevisiae : its relationship to specialized mitotic recombination and RNA polymerase II basal transcription

1995 • 43 citations

p53-Mediated DNA Repair Responses to UV Radiation: Studies of Mouse Cells Lacking p53, p21, and/orgadd45 Genes

2000 • 28 citations

Regulation of bcl-2 family in hydrogen peroxide-induced apoptosis in human leukemia HL-60 cells

2000 • 27 citations

Enhanced induction of Bax gene expression in H460 and H1299 cells with the combined treatment of cisplatin and adenovirus mediated wt-p53 gene transfer

2000 • 22 citations

Sensitivity of p53-Deficient Cells to Oxaliplatin and Thio-TEPA (N, N′, N″ Triethylenethiophosphoramide)

2002 • 10 citations

Base excision repair synthesis of DNA containing 8-oxoguanine in Escherichia coli

2003 • 9 citations

The nuclear 16-kD protein methylation increases in the early period of liver regeneration in a hepatectomized rat

2004 • 9 citations

Nucleotide excision repair in the yeast Saccharomyces cerevisiae: its relationship to specialized mitotic recombination and RNA polymerase II basal transcription

1995 • 5 citations