Role of p53 in Sensing Oxidative DNA Damage in Response to Reactive Oxygen Species-Generating Agents

Free radicals in biology and medicine

1991 • 17,840 citations

Surfing the p53 network

2000 • 6,487 citations

Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer

1996 • 2,327 citations

Reactions of oxyl radicals with DNA

1995 • 1,041 citations

Superoxide dismutase as a target for the selective killing of cancer cells

2000 • 824 citations

Oxidative Mechanisms in the Toxicity of Chromium and Cadmium Ions

2001 • 783 citations

Role of reactive oxygen species in apoptosis: implications for cancer therapy

2000 • 756 citations

Signaling Pathways in Reactive Oxygen Species–Induced Cardiomyocyte Apoptosis

1999 • 574 citations

p53 modulation of TFIIH–associated nucleotide excision repair activity

1995 • 555 citations

Induction of oxyradicals by arsenic: Implication for mechanism of genotoxicity

2001 • 533 citations

The Human OGG1 Gene: Structure, Functions, and Its Implication in the Process of Carcinogenesis

2000 • 460 citations

p53: 25 years after its discovery

2004 • 428 citations

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

1995 • 409 citations

Inhibition of DNA replication factor RPA by p53

1993 • 380 citations

p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction.

1996 • 346 citations

Passing the baton in base excision repair.

2000 • 338 citations

A role for p53 in base excision repair

2001 • 332 citations

Activation and activities of the p53 tumour suppressor protein

2001 • 307 citations

Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo

1999 • 241 citations

Mechanisms of switching on p53: a role for covalent modification?

1999 • 236 citations

Clinical implications of p53 mutations

1999 • 230 citations

Molecular and Cellular Effects of Ultraviolet Light-Induced Genotoxicity

1998 • 201 citations

Enzymology of the repair of free radicals-induced DNA damage

2002 • 194 citations

hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage

1999 • 181 citations

Physical and Functional Interaction between p53 and the Werner's Syndrome Protein

1999 • 181 citations

Redox signalling and transition metals in the control of the p53 pathway

2000 • 165 citations

p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain

1995 • 160 citations

Human p53 Binds Holliday Junctions Strongly and Facilitates Their Cleavage

1997 • 153 citations

Direct Detection of 8-Oxodeoxyguanosine and 8-Oxoguanine by Avidin and Its Analogues

1998 • 151 citations

Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery

1999 • 147 citations

Complexities of the DNA base excision repair pathway for repair of oxidative DNA damage

2001 • 137 citations

Antitumor Effects of Photodynamic Therapy Are Potentiated by 2-Methoxyestradiol

2002 • 128 citations

Signal Transduction Pathways in Hyperoxia-Induced Lung Cell Death

2000 • 125 citations

Interaction of p53 and DNA-PK in response to nucleoside analogues: potential role as a sensor complex for DNA damage.

2001 • 115 citations

The FANCG Fanconi anemia protein interacts with CYP2E1: possible role in protection against oxidative DNA damage

2002 • 104 citations

DNA binding properties of murine p53.

1988 • 100 citations

Hydrogen peroxide-induced apoptosis mediated by p53 protein in glial cells

1999 • 94 citations

Chromium(VI) Induces p53-Dependent Apoptosis in Diploid Human Lung and Mouse Dermal Fibroblasts

2000 • 84 citations

Structural and functional involvement of p53 in BER in vitro and in vivo

2001 • 71 citations

Clinical implications of p53: effect on prognosis, tumor progression and chemotherapy response

1998 • 55 citations

Acute arsenite-induced 8-hydroxyguanine is associated with inhibition of repair activity in cultured human cells

2002 • 42 citations

Inhibition of superoxide dismutase by 2-methoxyoestradiol analogues and oestrogen derivatives: structure-activity relationships.

2002 • 29 citations