Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains.

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES

1963 • 2,742 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

p53 function and dysfunction

1992 • 1,918 citations

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest.

1991 • 1,489 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

1984 • 874 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Construction and use of a safe and efficient amphotropic packaging cell line

1988 • 637 citations

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

1995 • 546 citations

p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts.

1991 • 455 citations

Small peptides activate the latent sequence-specific DNA binding function of p53

1995 • 444 citations

Two cellular proteins that bind to wild-type but not mutant p53.

1994 • 423 citations

Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.

1990 • 409 citations

Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding.

1992 • 344 citations

Enhanced proliferative potential in culture of cells from p53-deficient mice.

1993 • 341 citations

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53

1993 • 329 citations

Increased activity of p53 in senescing fibroblasts.

1995 • 303 citations

Human TAFII31 protein is a transcriptional coactivator of the p53 protein.

1995 • 297 citations

p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer.

1992 • 278 citations

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

1984 • 225 citations

Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.

1993 • 209 citations

Tumor suppression by RNA from the 3′ untranslated region of α-tropomyosin

1993 • 201 citations

The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation.

1995 • 188 citations

How loops, β sheets, and α helices help us to understand p53

1994 • 140 citations

Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA.

1993 • 138 citations

ras-Induced hyperplasia occurs with mutation of p53, but activated ras and myc together can induce carcinoma without p53 mutation

1992 • 133 citations

Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization.

1994 • 125 citations

Microtubule-active drugs taxol, vinblastine, and nocodazole increase the levels of transcriptionally active p53.

1995 • 120 citations

Nucleotide sequence of a cDNA encoding the rat p53 nuclear oncoprotein

1988 • 115 citations

Identification of a Minimal Transforming Domain of p53: Negative Dominance through Abrogation of Sequence-Specific DNA Binding

1992 • 113 citations

A direct effect of activated human p53 on nuclear DNA replication.

1995 • 87 citations

Tight DNA binding and oligomerization are dispensable for the ability of p53 to transactivate target genes and suppress transformation.

1993 • 70 citations

Mutant p53 tumor suppressor alleles release ras-induced cell cycle growth arrest.

1991 • 68 citations

Transcriptional repression by the C-terminal domain of p53.

1995 • 61 citations

Distinct residues of human p53 implicated in binding to DNA, simian virus 40 large T antigen, 53BP1, and 53BP2.

1994 • 60 citations

Isolation of dominant negative mutants and inhibitory antisense RNA sequences by expression selection of random DNA fragments

1992 • 53 citations

p53 domains: suppression, transformation, and transactivation.

1993 • 37 citations

The properties of p53 proteins selected for the loss of suppression of transformation.

1994 • 23 citations

Distinct Residues of Human p53 Implicated in Binding to DNA, Simian Virus 40 Large T Antigen, 53BP1, and 53BP2

1994 • 21 citations

Mutant p53 Tumor Suppressor Alleles Release ras-Induced Cell Cycle Growth Arrest

1991 • 15 citations

[Functional heterogeneity of p53-responsive elements].

1996 • 7 citations