Influence of Induced Reactive Oxygen Species in p53-Mediated Cell Fate Decisions

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

A simplified system for generating recombinant adenoviruses

1998 • 3,179 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

2001 • 2,226 citations

Apoptosis

2002 • 2,190 citations

A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin

1999 • 2,156 citations

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

2000 • 2,064 citations

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

1995 • 1,500 citations

PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells

2001 • 1,275 citations

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

2003 • 1,266 citations

p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53

2000 • 1,155 citations

Evaluation of 2′,7′-Dichlorofluorescin and Dihydrorhodamine 123 as Fluorescent Probes for Intracellular H2O2 in Cultured Endothelial Cells

1993 • 1,126 citations

Breaking the mitochondrial barrier

2001 • 947 citations

Induction of the growth inhibitor IGF-binding protein 3 by p53

1995 • 884 citations

Role ofBAXin the Apoptotic Response to Anticancer Agents

2000 • 854 citations

Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

1995 • 849 citations

Superoxide in Apoptosis

1998 • 773 citations

Glutathione : chemical, biochemical, and medical aspects

1989 • 746 citations

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.

1996 • 738 citations

Oxidative DNA damage and senescence of human diploid fibroblast cells.

1995 • 697 citations

Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species

1999 • 661 citations

Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.

1994 • 617 citations

The cellular response to p53: the decision between life and death

1999 • 594 citations

Reactive oxygen species are downstream mediators of p53-dependent apoptosis.

1996 • 590 citations

Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication

1998 • 436 citations

Mitochondrial decay in hepatocytes from old rats: Membrane potential declines, heterogeneity and oxidants increase

1997 • 427 citations

Ferredoxin reductase affects p53-dependent, 5-fluorouracil–induced apoptosis in colorectal cancer cells

2001 • 400 citations

PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family

2000 • 397 citations

Role for Mitochondrial Oxidants as Regulators of Cellular Metabolism

2000 • 387 citations

Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine.

1990 • 381 citations

bax -deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

1997 • 371 citations

Pidd, a new death-domain–containing protein, is induced by p53 and promotes apoptosis

2000 • 349 citations

Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence

2002 • 345 citations

Mechanisms of p53-mediated apoptosis

1999 • 303 citations

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant.

1996 • 299 citations

Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53

1997 • 295 citations

Differential Activation of Target Cellular Promoters by p53 Mutants with Impaired Apoptotic Function

1996 • 271 citations

Alterations in p53 and p16^INK4 Expression and Telomere Length during Spontaneous Immortalization of Li-Fraumeni Syndrome Fibroblasts

1995 • 248 citations

Annexin V used for measuring apoptosis in the early events of cellular cytotoxicity

1999 • 240 citations

Rho GTPase signalling pathways in the morphological changes associated with apoptosis

2002 • 239 citations

Nuclear and mitochondrial apoptotic pathways of p53

2001 • 225 citations

The p53 pathway and apoptosis

1999 • 222 citations

p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53

1999 • 200 citations

Senescence as a mode of tumor suppression.

1991 • 195 citations

APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis.

2001 • 189 citations

Escape from senescence in human diploid fibroblasts induced directly by mutant p53.

1994 • 177 citations

Catalytic subunit of DNA-dependent protein kinase: Impact on lymphocyte development and tumorigenesis

1999 • 176 citations

A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis

1997 • 171 citations

The thiol crosslinking agent diamide overcomes the apoptosis-inhibitory effect of Bcl-2 by enforcing mitochondrial permeability transition

1998 • 155 citations

Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53

2000 • 106 citations

Definition of the p53 Functional Domains Necessary for Inducing Apoptosis

2000 • 104 citations

Comparative analysis of apoptosis in HL60 detected by annexin-V and fluorescein-diacetate

1999 • 52 citations