ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk

Prognostic Implications of Echocardiographically Determined Left Ventricular Mass in the Framingham Heart Study

1990 • 5,586 citations

Wound Healing--Aiming for Perfect Skin Regeneration

1997 • 4,630 citations

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

1999 • 1,484 citations

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1996 • 1,473 citations

Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro

1993 • 1,347 citations

Estrogen-Induced Activation of Erk-1 and Erk-2 Requires the G Protein-Coupled Receptor Homolog, GPR30, and Occurs via Trans-Activation of the Epidermal Growth Factor Receptor through Release of HB-EGF

2000 • 1,265 citations

A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF

1991 • 1,135 citations

Role of the histone deacetylase complex in acute promyelocytic leukaemia

1998 • 1,091 citations

Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia

1998 • 1,021 citations

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

2004 • 965 citations

ErbB2 is essential in the prevention of dilated cardiomyopathy

2002 • 875 citations

Production and auto-induction of transforming growth factor-α in human keratinocytes

1987 • 870 citations

Role of Adiponectin in Preventing Vascular Stenosis

2002 • 811 citations

Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy

2002 • 727 citations

Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.

1993 • 658 citations

Epidermal growth factor receptors: critical mediators of multiple receptor pathways

1999 • 610 citations

Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation

1994 • 573 citations

Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL

1998 • 571 citations

Cardiomyopathy of Overload

1990 • 566 citations

Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding

1999 • 558 citations

Expression cloning of a diphtheria toxin receptor: Identity with a heparin-binding EGF-like growth factor precursor

1992 • 552 citations

A metalloprotease-disintegrin, MDC9/meltrin-gamma /ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor

1998 • 523 citations

Endothelin-1 induces hypertrophy with enhanced expression of muscle-specific genes in cultured neonatal rat cardiomyocytes.

1991 • 505 citations

ADAMs: focus on the protease domain

1998 • 472 citations

Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy

2002 • 461 citations

Proximal Events in Signaling by Plasma Membrane Estrogen Receptors

2003 • 460 citations

Myocyte hypertrophy in neonatal rat heart cultures and its regulation by serum and by catecholamines.

1982 • 428 citations

Tumor Necrosis Factor-α Converting Enzyme (TACE) Regulates Epidermal Growth Factor Receptor Ligand Availability

2002 • 415 citations

Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling

2003 • 414 citations

Ephrin-B Reverse Signaling Is Mediated by a Novel PDZ-RGS Protein and Selectively Inhibits G Protein–Coupled Chemoattraction

2001 • 382 citations

Heparin-binding EGF-like growth factor stimulation of smooth muscle cell migration: dependence on interactions with cell surface heparan sulfate

1993 • 365 citations

Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells

2002 • 354 citations

Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation

1997 • 348 citations

Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein.

1992 • 346 citations

SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor α (RARα) and PLZF-RARα oncoproteins associated with acute promyelocytic leukemia

1997 • 341 citations

Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function

2003 • 336 citations

Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury.

1993 • 334 citations

Multiple positive and negative regulators of signaling by the EGF-receptor

1999 • 330 citations

The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals

2001 • 320 citations

The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein–coupled receptors

2002 • 318 citations

Ectodomain Shedding of Epidermal Growth Factor Receptor Ligands Is Required for Keratinocyte Migration in Cutaneous Wound Healing

2000 • 303 citations

Reduced Retinoic Acid-Sensitivities of Nuclear Receptor Corepressor Binding to PML- and PLZF-RARα Underlie Molecular Pathogenesis and Treatment of Acute Promyelocytic Leukemia

1998 • 303 citations

The membrane protein CD9/DRAP 27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor.

1995 • 298 citations

Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis

2000 • 293 citations

Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein

1998 • 286 citations

Activation of MAPKs by Angiotensin II in Vascular Smooth Muscle Cells

2001 • 278 citations

Estrogen-Induced Activation of Erk-1 and Erk-2 Requires the G Protein-Coupled Receptor Homolog, GPR30, and Occurs via Trans-Activation of the Epidermal Growth Factor Receptor through Release of HB-EGF

2000 • 272 citations

Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity.

1995 • 270 citations

Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity.

1994 • 266 citations

Transactivation of the EGF Receptor Mediates IGF-1-stimulated Shc Phosphorylation and ERK1/2 Activation in COS-7 Cells

2000 • 253 citations

Membrane-anchored heparin-binding EGF-like growth factor (HB-EGF) and diphtheria toxin receptor-associated protein (DRAP27)/CD9 form a complex with integrin alpha 3 beta 1 at cell-cell contact sites.

1995 • 248 citations

Back signaling by the Nrg-1 intracellular domain

2003 • 237 citations

A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin.

1991 • 236 citations

Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes.

1994 • 233 citations

Mice Lacking the Metalloprotease-Disintegrin MDC9 (ADAM9) Have No Evident Major Abnormalities during Development or Adult Life

2002 • 209 citations

Angiotensin AT ₁ and AT ₂ Receptors Differentially Regulate Angiopoietin-2 and Vascular Endothelial Growth Factor Expression and Angiogenesis by Modulating Heparin Binding–Epidermal Growth Factor (EGF)–Mediated EGF Receptor Transactivation

2001 • 208 citations

The Shedding of Membrane-anchored Heparin-binding Epidermal-like Growth Factor Is Regulated by the Raf/Mitogen-activated Protein Kinase Cascade and by Cell Adhesion and Spreading

1999 • 185 citations

Leukemia translocation protein PLZF inhibits cell growth and expression of cyclin A

1999 • 182 citations

Sequence-specific DNA Binding and Transcriptional Regulation by the Promyelocytic Leukemia Zinc Finger Protein

1997 • 174 citations

Localization of heparin-binding EGF-like growth factor in the smooth muscle cells and macrophages of human atherosclerotic plaques.

1995 • 171 citations

The Promyelocytic Leukemia Zinc Finger Protein Affects Myeloid Cell Growth, Differentiation, and Apoptosis

1998 • 167 citations

Plzf Mediates Transcriptional Repression of HoxD Gene Expression through Chromatin Remodeling

2002 • 162 citations

Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF

2003 • 160 citations

Characterization of sequences within heparin-binding EGF-like growth factor that mediate interaction with heparin.

1994 • 152 citations

Oxidative and Osmotic Stress Signaling in Tumor Cells Is Mediated by ADAM Proteases and Heparin-Binding Epidermal Growth Factor

2004 • 149 citations

Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities

2003 • 145 citations

Phenotypic Analysis of Meltrin α (ADAM12)-Deficient Mice: Involvement of Meltrin α in Adipogenesis and Myogenesis

2002 • 145 citations

Wnt1 and Wnt5a induce cyclin D1 expression through ErbB1 transactivation in HC11 mammary epithelial cells

2003 • 135 citations

Metalloprotease-dependent Protransforming Growth Factor-α Ectodomain Shedding in the Absence of Tumor Necrosis Factor-α-converting Enzyme

2001 • 133 citations

Leukemia translocation gene, PLZF, is expressed with a speckled nuclear pattern in early hematopoietic progenitors

1995 • 129 citations

Growth Suppression by Acute PromyelocyticLeukemia-Associated Protein PLZF Is Mediated by Repression of c-myc Expression

2003 • 125 citations

BAG-1: a multifunctional regulator of cell growth and survival

2003 • 122 citations

Heparin-dependent binding and autophosphorylation of epidermal growth factor (EGF) receptor by heparin-binding EGF-like growth factor but not by EGF.

1994 • 122 citations

N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration

2001 • 121 citations

Extracellular calcium influx stimulates metalloproteinase cleavage and secretion of heparin-binding EGF-like growth factor independently of protein kinase C

1998 • 119 citations

Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain.

1995 • 115 citations

Helicobacter pylori-stimulated EGF receptor transactivation requires metalloprotease cleavage of HB-EGF

2002 • 114 citations

HB-EGF directs stromal cell polyploidy and decidualization via cyclin D3 during implantation

2003 • 112 citations

Heparin-binding ligands mediate autocrine epidermal growth factor receptor activation In skin organ culture.

1997 • 107 citations

Signaling Downstream of Eph Receptors and Ephrin Ligands

2001 • 102 citations

The mechanism of cleavage of EGFR ligands induced by inflammatory cytokines in gastric cancer cells

2004 • 99 citations

Role of heparin-binding epidermal growth factor–like growth factor as a hepatotrophic factor in rat liver regeneration after partial hepatectomy

1995 • 96 citations

Heparin-Binding EGF-like Growth-Factor Is a Potent Mitogen for Rat Hepatocytes

1994 • 91 citations

Epidermal growth factor system is a physiological regulator of development of the mouse fetal submandibular gland and regulates expression of the α6-integrin subunit

1997 • 89 citations

PACSIN3 Binds ADAM12/Meltrin α and Up-regulates Ectodomain Shedding of Heparin-binding Epidermal Growth Factor-like Growth Factor

2003 • 89 citations

Heparin-binding EGF-like growth factor mediates the biological effects of P450 arachidonate epoxygenase metabolites in epithelial cells

2002 • 84 citations

Association of the transmembrane TGF-alpha precursor with a protein kinase complex.

1994 • 83 citations

ADAM Binding Protein Eve-1 Is Required for Ectodomain Shedding of Epidermal Growth Factor Receptor Ligands

2004 • 83 citations

Heparin-binding epidermal growth factor-like growth factor mRNA expression in neonatal rat brain with hypoxic/ischemic injury

1999 • 83 citations

Epithelial morphogenesis in mouse embryonic submandibular gland: Its relationships to the tissue organization of epithelium and mesenchyme

1997 • 82 citations

Biosynthesis and Processing by Phorbol Ester of the Cell Surface-Associated Precursor Form of Heparin-Binding EGF-like Growth Factor

1994 • 77 citations

Possible role of coexpression of CD9 with membrane-anchored heparin-binding EGF-like growth factor and amphiregulin in cultured human keratinocyte growth

1997 • 77 citations

Eosinophils expressing heparin-binding EGF-like growth factor mRNA localize around lung microvessels in pulmonary hypertension.

1993 • 73 citations

BAG-1 Is a Novel Cytoplasmic Binding Partner of the Membrane Form of Heparin-binding EGF-like Growth Factor

2001 • 71 citations

Structure-Function Analysis of Bag1 Proteins

2001 • 68 citations

Growth regulation by oncogenes — new insights from model organisms

2001 • 68 citations

Involvement of Heparin-Binding EGF-like Growth Factor and Its Processing by Metalloproteinases in Early Epithelial Morphogenesis of the Submandibular Gland

2001 • 65 citations

Expression of Heparin-Binding Epidermal Growth Factor–Like Growth Factor in Neointimal Cells Induced by Balloon Injury in Rat Carotid Arteries

1996 • 59 citations

Dual intracellular signaling by proteolytic cleavage of membrane-anchored heparin-binding EGF-like growth factor

2003 • 58 citations

α2B-Adrenergic Receptor Activates MAPK via a Pathway Involving Arachidonic Acid Metabolism, Matrix Metalloproteinases, and Epidermal Growth Factor Receptor Transactivation

2002 • 48 citations

Inhibition of vascular smooth muscle cell proliferation by a novel fibroblast growth factor receptor antagonist

2002 • 34 citations

Osmotic Stress Induces HB-EGF Gene Expression via Ca2+/Pyk2/JNK Signal Cascades in Rat Aortic Smooth Muscle Cells

2001 • 34 citations

Heparin-binding EGF-like growth factor is expressed by mesangial cells and is involved in mesangial proliferation in glomerulonephritis

1999 • 32 citations

Deregulated Bag‐1 protein expression in human oral squamous cell carcinomas and lymph node metastases

2002 • 32 citations

Roles of charged amino acid residues in the cytoplasmic domain of proHB-EGF

2004 • 6 citations