The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein–coupled receptors

An Essential Role for Ectodomain Shedding in Mammalian Development

1998 • 1,607 citations

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

1999 • 1,484 citations

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1996 • 1,473 citations

ECM and Cell Surface Proteolysis: Regulating Cellular Ecology

1997 • 1,311 citations

The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis

1999 • 916 citations

A metalloprotease-disintegrin, MDC9/meltrin-gamma /ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor

1998 • 523 citations

Regulated Cleavage of a Contact-Mediated Axon Repellent

2000 • 522 citations

Kuzbanian Controls Proteolytic Processing of Notch and Mediates Lateral Inhibition during Drosophila and Vertebrate Neurogenesis

1997 • 516 citations

Functional Analysis of the Domain Structure of Tumor Necrosis Factor-α Converting Enzyme

2000 • 496 citations

ADAMs: focus on the protease domain

1998 • 472 citations

Processing of the Notch Ligand Delta by the Metalloprotease Kuzbanian

1999 • 413 citations

New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades

2001 • 397 citations

Employment of the Epidermal Growth Factor Receptor in Growth Factor–Independent Signaling Pathways

1999 • 271 citations

Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor

1999 • 262 citations

Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades

1999 • 248 citations

Remarkable roles of proteolysis on and beyond the cell surface

2000 • 235 citations

Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin α6β1: Implications for murine fertilization

1999 • 223 citations

Epidermal Growth Factor (EGF) Receptor-dependent ERK Activation by G Protein-coupled Receptors

2001 • 215 citations

Autocrine and paracrine signaling through neuropeptide receptors in human cancer

2001 • 196 citations

The Tetraspanin Cd9 Associates with Transmembrane TGF-α and Regulates TGF-α–Induced Egf Receptor Activation and Cell Proliferation

2000 • 162 citations

Shedding of c-Met is regulated by crosstalk between a G-protein coupled receptor and the EGF receptor and is mediated by a TIMP-3 sensitive metalloproteinase

2014 • 112 citations

Shedding of c-Met is regulated by crosstalk between a G-protein coupled receptor and the EGF receptor and is mediated by a TIMP-3 sensitive metalloproteinase

2001 • 105 citations

The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone

2000 • 82 citations

Potentiation of the inhibitory effect of growth hormone-releasing hormone antagonists on PC-3 human prostate cancer by bombesin antagonists indicative of interference with both IGF and EGF pathways

2000 • 66 citations