BAG-1: a multifunctional regulator of cell growth and survival

Mitochondria and Apoptosis

1998 • 8,909 citations

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

Mechanisms Underlying Ubiquitination

2001 • 3,555 citations

CLINICAL CANCER RESEARCH

1956 • 1,729 citations

Heat shock proteins.

1990 • 1,365 citations

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

1999 • 1,134 citations

Bcl-2 family proteins

1998 • 1,055 citations

Role of the Heat Shock Response and Molecular Chaperones in Oncogenesis and Cell Death

2000 • 1,028 citations

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

2000 • 971 citations

Role of the Human Heat Shock Protein hsp70 in Protection against Stress-Induced Apoptosis

1997 • 961 citations

Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

1995 • 863 citations

Expression of Apoptosis-Regulating Proteins in Chronic Lymphocytic Leukemia: Correlations With In Vitro and In Vivo Chemoresponses

1998 • 656 citations

HSP90 as a new therapeutic target for cancer therapy: the story unfolds

2002 • 526 citations

BAG-1 modulates the chaperone activity of Hsp70/Hsc70

1997 • 511 citations

An Evolutionarily Conserved Family of Hsp70/Hsc70 Molecular Chaperone Regulators

1999 • 509 citations

CONTROL OF TRANSLATION INITIATION IN ANIMALS

1998 • 507 citations

The Ubiquitin-related BAG-1 Provides a Link between the Molecular Chaperones Hsc70/Hsp70 and the Proteasome

2000 • 478 citations

Structure of a Bag/Hsc70 Complex: Convergent Functional Evolution of Hsp70 Nucleotide Exchange Factors

2001 • 427 citations

Prevention of Constitutive TNF Receptor 1 Signaling by Silencer of Death Domains

1999 • 408 citations

GrpE-like regulation of the Hsc70 chaperone by the anti-apoptotic protein BAG-1

1997 • 397 citations

Molecular chaperone targeting and regulation by BAG family proteins

2001 • 390 citations

Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling

2001 • 371 citations

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.

1996 • 364 citations

A molecular chaperone complex at the lysosomal membrane is required for protein translocation

2001 • 362 citations

From the cradle to the grave: molecular chaperones that may choose between folding and degradation

2001 • 328 citations

HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death.

1996 • 318 citations

Ubiquitin-dependent Degradation of Certain Protein Substrates in Vitro Requires the Molecular Chaperone Hsc70

1997 • 294 citations

Bag1–Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth

2001 • 279 citations

Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines.

1998 • 221 citations

Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange.

2001 • 220 citations

p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1

1998 • 203 citations

Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation

1997 • 195 citations

BAG-1L Protein Enhances Androgen Receptor Function

1998 • 195 citations

Molecular Chaperone Interactions with Steroid Receptors: an Update

2000 • 193 citations

Ubiquitylation of BAG-1 Suggests a Novel Regulatory Mechanism during the Sorting of Chaperone Substrates to the Proteasome

2002 • 189 citations

A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning.

1995 • 186 citations

BAG-1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from substrate release

1998 • 179 citations

Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53

2001 • 168 citations

Bag-1M Accelerates Nucleotide Release for Human Hsc70 and Hsp70 and Can Act Concentration-dependent as Positive and Negative Cofactor

2001 • 163 citations

Prolonged cell survival enhances peritoneal dissemination of gastric cancer cells

1998 • 159 citations

Mammalian protein RAP46: an interaction partner and modulator of 70kDa heat shock proteins

1997 • 157 citations

Structural analysis of BAG1 cochaperone and its interactions with Hsc70 heat shock protein.

2001 • 149 citations

Hsp70 chaperone machines

2001 • 146 citations

RAP46 Is a Negative Regulator of Glucocorticoid Receptor Action and Hormone-induced Apoptosis

1998 • 144 citations

Human BAG-1/RAP46 protein is generated as four isoforms by alternative translation initiation and overexpressed in cancer cells

1998 • 144 citations

The anti‐apoptotic protein BAG‐3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines

2001 • 140 citations

Bag1 Functions In Vivo as a Negative Regulator of Hsp70 Chaperone Activity

2000 • 137 citations

Interaction of BAG-1 with Retinoic Acid Receptor and Its Inhibition of Retinoic Acid-induced Apoptosis in Cancer Cells

1998 • 131 citations

Anti-cell death activity promotes pulmonary metastasis of melanoma cells

1997 • 129 citations

Human DnaJ Homologs dj2 and dj3, and bag-1 Are Positive Cochaperones of hsc70

2000 • 121 citations

Modulation of in Vivo HSP70 Chaperone Activity by Hip and Bag-1

2001 • 120 citations

Bcl-2 gene family and related proteins in mammary gland involution and breast cancer.

1999 • 116 citations

Selective regulation ofBcl-X_Lby a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies

1998 • 110 citations

Proteins interacting with the molecular chaperone hsp70/hsc70: physical associations and effects on refolding activity

1997 • 108 citations

Cooperative Interception of Neuronal Apoptosis by BCL‐2 and BAG‐1 Expression: Prevention of Caspase Activation and Reduced Production of Reactive Oxygen Species

1997 • 108 citations

BAG-1: A Novel Biomarker Predicting Long-Term Survival in Early-Stage Breast Cancer

2001 • 107 citations

Regulation of the heat shock conjugate Hsc70 in the mammalian cell: the characterization of the anti-apoptotic protein BAG-1 provides novel insights.

1998 • 106 citations

Characterization of Interactions between the Anti-apoptotic Protein BAG-1 and Hsc70 Molecular Chaperones

1998 • 103 citations

Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper

2001 • 100 citations

A Nuclear Action of the Eukaryotic Cochaperone Rap46 in Downregulation of Glucocorticoid Receptor Activity

1999 • 96 citations

Isolation of Bcl-2 Binding Proteins That Exhibit Homology with BAG-1 and Suppressor of Death Domains Protein

2001 • 94 citations

Role of Bag-1 in the Survival and Proliferation of the Cytokine-Dependent Lymphocyte Lines, Ba/F3 and Nb2

1997 • 93 citations

Differential Effects of the hsp70-binding Protein BAG-1 on Glucocorticoid Receptor Folding by the hsp90-based Chaperone Machinery

1999 • 93 citations

The p36 isoform of BAG-1 is translated by internal ribosome entry following heat shock

2001 • 88 citations

Distinct Isoforms of the Cofactor BAG-1 Differentially Affect Hsc70 Chaperone Function

2000 • 85 citations

The hsp70-associating protein Hap46 binds to DNA and stimulates transcription

1999 • 82 citations

Prediction of Novel Bag-1 Homologs Based on Structure/Function Analysis Identifies Snl1p as an Hsp70 Co-chaperone in Saccharomyces cerevisiae

2002 • 80 citations

High level expression of differentially localized BAG-1 isoforms in some oestrogen receptor-positive human breast cancers

1999 • 74 citations

BAG-1 Is a Novel Cytoplasmic Binding Partner of the Membrane Form of Heparin-binding EGF-like Growth Factor

2001 • 71 citations

Structure-Function Analysis of Bag1 Proteins

2001 • 68 citations

Bag1 is a regulator and marker of neuronal differentiation

2002 • 67 citations

BAG-1 expression and function in human cancer

2002 • 65 citations

Growth Hormone Prevents Apoptosis through Activation of Nuclear Factor-κB in Interleukin-3-Dependent Ba/F3 Cell Line

2000 • 60 citations

hsp70 Interacting Protein Hip Does Not Affect Glucocorticoid Receptor Folding by the hsp90-Based Chaperone Machinery Except To Oppose the Effect of BAG-1

2000 • 59 citations

BAG4/SODD Protein Contains a Short BAG Domain

2002 • 59 citations

BAG-1 family of cochaperones in the modulation of nuclear receptor action

2001 • 58 citations

BAG1L Enhances Trans-activation Function of the Vitamin D Receptor

2000 • 55 citations

Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants

1999 • 53 citations

Biochimica et Biophysica Acta

1979 • 53 citations

Bcl‐2, Raf‐1 and mitochondrial regulation of apoptosis

1998 • 52 citations

BAG-1 accelerates cell motility of human gastric cancer cells

1999 • 52 citations

BAG‐1, An Anti‐Apoptotic Tumour Marker

2002 • 52 citations

Molecular Chaperone Interactions with Steroid Receptors: an Update

2000 • 50 citations

Bag1 proteins regulate growth and survival of ZR-75-1 human breast cancer cells.

2002 • 50 citations

Cloning of cDNAs Encoding the Human BAG1 Protein and Localization of the HumanBAG1Gene to Chromosome 9p12

1996 • 49 citations

Overexpression of Anti-apoptotic Gene BAG-1 in Human Cervical Cancer

1999 • 45 citations

Differential expression of antiapoptotic gene BAG-1 in human breast normal and cancer cell lines and tissues.

1999 • 44 citations

Tumor Necrosis Factor Receptor 1 Is an ATPase Regulated by Silencer of Death Domain

2002 • 43 citations

Alteration of the stability of Bag-1 protein in the control of olfactory neuronal apoptosis

2001 • 41 citations

Interference between Proteins Hap46 and Hop/p60, Which Bind to Different Domains of the Molecular Chaperone hsp70/hsc70

1998 • 41 citations

Hsp70-RAP46 interaction in downregulation of DNA binding by glucocorticoid receptor

2000 • 40 citations

Synergistic effect of Bcl-2 and BAG-1 on the prevention of photoreceptor cell death.

2000 • 37 citations

Fibroblast Growth Factor-2 Stimulates Endothelial Nitric Oxide Synthase Expression and Inhibits Apoptosis by a Nitric Oxide-Dependent Pathway in Nb2 Lymphoma Cells¹

2001 • 35 citations

Cofactor-lnduced Modulation of the Functional Specificity of the Molecular Chaperone Hsc70

1998 • 35 citations

BAG-1 p50 Isoform Interacts with the Vitamin D Receptor and Its Cellular Overexpression Inhibits the Vitamin D Pathway

2001 • 35 citations

Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine- rich region within IL-2 receptor beta c chain

1996 • 34 citations

Transcriptional activation by the human Hsp70-associating protein Hap50

2001 • 33 citations

Bag‐1 and Bcl‐2 Gene Transfer in Malignant Glioma: Modulation of Cell Cycle Regulation and Apoptosis

2000 • 33 citations

Deregulated Bag‐1 protein expression in human oral squamous cell carcinomas and lymph node metastases

2002 • 32 citations

BAG-1 Promotes Apoptosis Induced by N-(4-hydroxyphenyl)retinamide in Human Cervical Carcinoma Cells

2000 • 30 citations

BAG-1 inhibits p53-induced but not apoptin-induced apoptosis

1997 • 30 citations

Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine- rich region within IL-2 receptor beta c chain

1996 • 27 citations

Regulation of programmed cell death following T cell activation in vivo.

1998 • 27 citations

Role of Bag-1 in the Survival and Proliferation of the Cytokine-Dependent Lymphocyte Lines, Ba/F3 and Nb2

1997 • 24 citations

Loss of bag-1 immunoreactivity in rat brain after transient middle cerebral artery occlusion

2000 • 23 citations

Growth Hormone Prevents Apoptosis through Activation of Nuclear Factor- B in Interleukin-3-Dependent Ba/F3 Cell Line

2000 • 23 citations

BAG-1, a novel Bcl-2-interacting protein, activates expression of human JC virus

2000 • 23 citations

Bag-1 up-regulation in anti-CD4 mAb treated allo-activated T cells confers resistance to apoptosis

2002 • 20 citations

IFN-γ Upregulates Anti-Apoptotic Gene Expression and Inhibits Apoptosis in IL-3-Dependent Hematopoietic Cells

1997 • 19 citations

BAG-1M, an Isoform of Bcl-2-Interacting Protein BAG-1, Enhances Gene Expression Driven by CMV Promoter

2001 • 19 citations

Fibroblast Growth Factor-2 Stimulates Endothelial Nitric Oxide Synthase Expression and Inhibits Apoptosis by a Nitric Oxide-Dependent Pathway in Nb2 Lymphoma Cells

2001 • 16 citations

Dissection of the ATP-binding Domain of the Chaperone hsc70 for Interaction with the Cofactor Hap46

2001 • 13 citations