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Close relation of endothelial function in the human coronary and peripheral circulations

1995 • 2,061 citations

Upregulation of Endothelial Nitric Oxide Synthase by HMG CoA Reductase Inhibitors

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Cholesterol Lowering With Simvastatin Improves Prognosis of Diabetic Patients With Coronary Heart Disease: A subgroup analysis of the Scandinavian Simvastatin Survival Study (4S)

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1986 • 1,211 citations

Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes.

1991 • 1,161 citations

Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.

1993 • 1,102 citations

L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans.

1992 • 822 citations

Acute Hyperglycemia Attenuates Endothelium-Dependent Vasodilation in Humans In Vivo

1998 • 790 citations

High Glucose Increases Nitric Oxide Synthase Expression and Superoxide Anion Generation in Human Aortic Endothelial Cells

1997 • 765 citations

Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.

1996 • 730 citations

Non-invasive measurement of human endothelium dependent arterial responses: accuracy and reproducibility.

1995 • 716 citations

Statins do more than just lower cholesterol

1996 • 714 citations

Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanistic study with N alpha-acetylarginine, N alpha-acetylcysteine, and N alpha-acetyllysine, and bovine serum albumin.

1994 • 673 citations

Magnitude and determinants of coronary artery disease in juvenile-onset, insulin-dependent diabetes mellitus

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Lipid advanced glycosylation: pathway for lipid oxidation in vivo.

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Free radicals mediate endothelial cell dysfunction caused by elevated glucose

1992 • 566 citations

Oxidized Low-density Lipoprotein Decreases the Expression of Endothelial Nitric Oxide Synthase

1995 • 547 citations

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1992 • 527 citations

Effect of intensive diabetes management on macrovascular events and risk factors in the diabetes control and complications trial

1995 • 508 citations

Inactivation of endothelial derived relaxing factor by oxidized lipoproteins.

1992 • 452 citations

Impaired vascular reactivity in insulin-dependent diabetes mellitus is related to disease duration and low density lipoprotein cholesterol levels

1996 • 416 citations

Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults.

1996 • 413 citations

Vascular function in the forearm of hypercholesterolaemic patients off and on lipid-lowering medication

1995 • 401 citations

Kinetics of HbA1c, Glycated Albumin, and Fructosamine and Analysis of Their Weight Functions Against Preceding Plasma Glucose Level

1995 • 361 citations

Elevatedl-Arginine/Dimethylarginine Ratio Contributes to Enhanced Systemic NO Production by Dietaryl-Arginine in Hypercholesterolemic Rabbits

1996 • 308 citations

Atherosclerosis and the Two Faces of Endothelial Nitric Oxide Synthase

1998 • 298 citations

Randomized, Double-Blind, Placebo-Controlled Study of Supplemental Oral <scp>l</scp> -Arginine in Patients With Heart Failure

1996 • 278 citations

Endothelium-Mediated Vascular Function in Insulin-Dependent Diabetes Mellitus

1995 • 220 citations

Inhibition of Nitric Oxide Synthesis in Forearm Vasculature of Insulin-Dependent Diabetic Patients: Blunted Vasoconstriction in Patients with Microalbuminuria

1993 • 214 citations

Interactions between L-arginine and L-glutamine change endothelial NO production. An effect independent of NO synthase substrate availability.

1995 • 182 citations

Regression or Progression

1996 • 181 citations

The vascular effects of L-Arginine in humans. The role of endogenous insulin.

1997 • 161 citations

Amelioration by L-Arginine of a Dysfunctional Arginine/Nitric Oxide Pathway in Diabetic Endothelium

1995 • 161 citations

Endothelium-Dependent Relaxation in Aorta of BB Rat

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Early endothelial dysfunction in adults at risk from atherosclerosis: different responses to l-arginine

1998 • 112 citations

Inhibitors of Arterial Relaxation Among Components of Human Oxidized Low-Density Lipoproteins

1997 • 96 citations

Impaired arginine metabolism and NO synthesis in coronary endothelial cells of the spontaneously diabetic BB rat

1995 • 86 citations

Arginine: A New Therapy for Atherosclerosis?

1997 • 85 citations

Endothelial dysfunction in a model of hyperglycemia and hyperinsulinemia

1995 • 81 citations

Vascular and Hormonal Responses to Arginine: Provision of Substrate for Nitric Oxide or Non-Specific Effect?

1995 • 71 citations

Endothelial dysfunction of conduit arteries in insulin-dependent diabetes mellitus without microalbuminuria

1997 • 65 citations

THE ASSOCIATION OF REDUCED ENDOTHELIUM DERIVED RELAXING FACTOR-NO PRODUCTION WITH ENDOTHELIAL DAMAGE AND INCREASED IN VIVO PLATELET ACTIVATION IN PATIENTS WITH DIABETES MELLITUS

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The effect of high glucose on polyol pathway activity and myoinositol metabolism in cultured human endothelial cells

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Increased susceptibility of LDL to in vitro oxidation in patients with insulin-dependent and non-insulin-dependent diabetes mellitus.

1994 • 39 citations

Flow-induced dilatation in isolated resistance arteries from control and streptozotocin-diabetic rats

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Restoration of vascular endothelial function in diabetes

1996 • 11 citations