Dietary antioxidant supplementation reduces lipid peroxidation but impairs vascular function in small mesenteric arteries of the streptozotocin-diabetic rat

Analysis of serial measurements in medical research.

1990 • 3,078 citations

Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)

1996 • 2,163 citations

Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats.

1977 • 2,105 citations

A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.

1990 • 1,896 citations

Direct observation of a free radical interaction between vitamin E and vitamin C

1979 • 1,460 citations

Diabetes mellitus and free radicals

1993 • 666 citations

Modulation of Oxidant Stress In Vivo in Chronic Cigarette Smokers

1996 • 621 citations

Oxidized Low-density Lipoprotein Decreases the Expression of Endothelial Nitric Oxide Synthase

1995 • 547 citations

The isoprostanes

1996 • 451 citations

Plasma 8‐epi‐PGF_2α levels are elevated in individuals with non‐insulin dependent diabetes mellitus

1995 • 394 citations

Antioxidant treatment of diabetic rats inhibits lipoprotein oxidation and cytotoxicity.

1989 • 265 citations

DISFUNCTION OF VASCULAR ENDOTHELIUM IN DIABETES MELLITUS

1993 • 259 citations

Contraction of diabetic rabbit aorta caused by endothelium-derived PGH2-TxA2

1989 • 245 citations

Low-dose alpha-tocopherol improves and high-dose alpha-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits.

1994 • 229 citations

Endothelium-Mediated Vascular Function in Insulin-Dependent Diabetes Mellitus

1995 • 220 citations

Native and oxidized low‐density lipoproteins have different inhibitory effects on endothelium‐derived relaxing factor in the rabbit aorta

1990 • 183 citations

Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart: influence of tocopherol as antioxidant

1995 • 157 citations

Coronary artery constriction by the isoprostane 8‐epi prostaglandin F_2α

1996 • 142 citations

Analysis of F2-isoprostanes as indicators of non-enzymatic lipid peroxidation in vivo by gas chromatography-mass spectrometry: development of a solid-phase extraction procedure

1995 • 140 citations

Endothelium‐dependent relaxation and noradrenaline sensitivity in mesenteric resistance arteries of streptozotocin‐induced diabetic rats

1992 • 140 citations

Impaired Contraction and Endothelium-Dependent Relaxation in Isolated Resistance Vessels from Patients with Insulin-Dependent Diabetes Mellitus

1994 • 139 citations

Chronic vitamin E treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta

1995 • 138 citations

Effects of natural free radical scavengers on peripheral nerve and neurovascular function in diabetic rats

1995 • 115 citations

Deficiency of Ascorbic Acid in Experimental Diabetes: Relationship With Collagen and Polyol Pathway Abnormalities

1988 • 89 citations

Loss of α‐tocopherol upon exposure to nitric oxide or the sydnonimine SIN‐1

1993 • 86 citations

Production of 12-Hydroxyeicosatetraenoic Acid and Vitamin E Status in Platelets from Type I Human Diabetic Subjects

1985 • 80 citations

Oxidative Stress and Lipids in Diabetes: A Role in Endothelium Vasodilator Dysfunction?

1996 • 77 citations

Selective Impairment of Acetylcholine-Mediated Endothelium-Dependent Relaxation in Isolated Resistance Arteries of the Streptozotocin-Induced Diabetic Rat

1995 • 70 citations

The effect of probucol and vitamin E treatment on the oxidation of low‐density lipoprotein and forearm vascular responses in humans

1994 • 64 citations

Formation of PGF2-Isoprostanes During the Oxidative Modification of Low Density Lipoprotein

1994 • 59 citations

Plasma vitamin A and E in type 1 (insulin-dependent) and type 2 (non-insulin-dependent) adult diabetic patients.

1991 • 51 citations

Tissue antioxidant status in streptozotocin-induced diabetes in rats

1992 • 45 citations

Flow-induced dilatation in isolated resistance arteries from control and streptozotocin-diabetic rats

1998 • 36 citations

Deficiency of ascorbic acid in experimental diabetes. Relationship with collagen and polyol pathway abnormalities

1988 • 32 citations

NO-Redox Paradox: Direct Oxidation of α-Tocopherol and α-Tocopherol-Mediated Oxidation of Ascorbate

1996 • 27 citations

Effects of natural free radical scavengers on peripheral nerve and neurovascular function in diabetic rats

1995 • 16 citations