Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

Nitric oxide synthases: Roles, tolls, and controls

1994 • 2,945 citations

The Reaction of no With Superoxide

1993 • 2,133 citations

Hypercholesterolemia increases endothelial superoxide anion production.

1993 • 1,799 citations

Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.

1993 • 1,102 citations

Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions.

1994 • 1,102 citations

Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.

1990 • 1,020 citations

Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis.

1991 • 1,010 citations

Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.

1996 • 884 citations

Nitric oxide: mediator, murderer, and medicine

1994 • 836 citations

Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells.

1992 • 828 citations

L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans.

1992 • 822 citations

Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine

1991 • 813 citations

Macrophage Oxidation of L-Arginine to Nitric Oxide, Nitrite, and Nitrate

1989 • 681 citations

Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase

1992 • 534 citations

Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta.

1990 • 527 citations

Native Low-Density Lipoprotein Increases Endothelial Cell Nitric Oxide Synthase Generation of Superoxide Anion

1995 • 479 citations

Evidence that selective endothelial dysfunction may occur in the absence of angiographic or ultrasound atherosclerosis in patients with risk factors for atherosclerosis

1994 • 457 citations

The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine.

1990 • 456 citations

Nitric oxide activity in the human coronary circulation. Impact of risk factors for coronary atherosclerosis.

1995 • 455 citations

Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle.

1992 • 444 citations

Impaired Endothelium-Dependent Vasodilation in Patients With Essential Hypertension

1995 • 430 citations

Brain nitric oxide synthase is a biopterin‐ and flavin‐containing multi‐functional oxido‐reductase

1991 • 422 citations

Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia

1996 • 411 citations

Measuring Forearm Blood Flow and Interpreting the Responses to Drugs and Mediators

1995 • 402 citations

Vascular function in the forearm of hypercholesterolaemic patients off and on lipid-lowering medication

1995 • 401 citations

Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity.

1994 • 365 citations

Tetrahydrobiopterin and Dysfunction of Endothelial Nitric Oxide Synthase in Coronary Arteries

1995 • 295 citations

Structural analysis of porcine brain nitric oxide synthase reveals a role for tetrahydrobiopterin and L-arginine in the formation of an SDS-resistant dimer.

1995 • 292 citations

Vascular endothelium: An integrator of pathophysiologic stimuli in atherosclerosis

1995 • 230 citations

Interactions between L-arginine and L-glutamine change endothelial NO production. An effect independent of NO synthase substrate availability.

1995 • 182 citations

Physiologic consequences of increased vascular oxidant stresses in hypercholesterolemia and atherosclerosis: Implications for impaired vasomotion

1995 • 170 citations

Tetrahydrobiopterin-dependent formation of endothelium-derived relaxing factor (nitric oxide) in aortic endothelial cells

1992 • 162 citations

The pathogenesis of cardiovascular disease: role of the endothelium as a target and mediator

1995 • 150 citations

In search of a function for tetrahydrobiopterin in the biosynthesis of nitric oxide

1995 • 129 citations

Effect of Tetrahydrobiopterin on Endothelial Function in Canine Middle Cerebral Arteries

1996 • 94 citations

Cysteine 99 of Endothelial Nitric Oxide Synthase (NOS-III) Is Critical for Tetrahydrobiopterin-Dependent NOS-III Stability and Activity

1995 • 86 citations

Inducible nitric oxide synthase: identification of amino acid residues essential for dimerization and binding of tetrahydrobiopterin.

1995 • 77 citations

Familial Hypercholesterolemia

1982 • 58 citations

Modular Structure of Neuronal Nitric Oxide Synthase: Localization of the Arginine Binding Site and Modulation by Pterin

1995 • 50 citations

Products of the Tyrosine-Dependent Oxidation of Tetrahydrobiopterin by Rat Liver Phenylalanine Hydroxylase

1993 • 49 citations

Impaired endothelial function in patients with nephritic range proteinuria

1995 • 45 citations

Tetrahydrobiopterin as Another EDRF in Man

1994 • 40 citations

Tetrahydrobiopterin deficiency and brain nitric oxide synthase in thehph1 mouse

1994 • 39 citations

Reduction of Quinonoid Dihydrobiopterin to Tetrahydrobiopterin by Nitric Oxide Synthase

1996 • 37 citations

A microcomputer-based, R-wave triggered system for hemodynamic measurements in the forearm

1988 • 37 citations

No Functional Involvement of 5-Hydroxytryptamine1A Receptors in Nitric Oxide-Dependent Dilatation Caused by Serotonin in the Human Forearm Vascular Bed

1994 • 22 citations

Inhibition of Acetylcholinesterase Selectively Potentiates NG-Monomethyl-<scp>l</scp>-Arginine-Resistant Actions of Acetylcholine in Human Forearm Vasculature

1995 • 20 citations

Tetrahydrobiopterin induces vasodilatation via enhancement of cGMP level

1992 • 18 citations

The pathogenesis of cardiovascular disease: role of the endothelium as a target and mediator

1995 • 9 citations

Tetrahydrobiopterin induces vasodilation via enhancement of cGMP level

1993 • 2 citations