Vitamin C Improves Endothelium-Dependent Vasodilation in Patients With Insulin-Dependent Diabetes Mellitus

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Diabetic Retinopathy

1974 • 5,744 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Classification and Diagnosis of Diabetes Mellitus and Other Categories of Glucose Intolerance

1979 • 4,730 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

Ascorbate is an outstanding antioxidant in human blood plasma.

1989 • 1,876 citations

Hypercholesterolemia increases endothelial superoxide anion production.

1993 • 1,799 citations

EFFECTS OF ENDOTHELIUM-DERIVED NITRIC OXIDE ON PERIPHERAL ARTERIOLAR TONE IN MAN

1989 • 1,625 citations

The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population‐based cohort

1993 • 1,410 citations

Glucose autoxidation and protein modification. The potential role of ‘autoxidative glycosylation’ in diabetes

1987 • 1,278 citations

Antioxidant defenses and lipid peroxidation in human blood plasma.

1988 • 1,253 citations

Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.

1993 • 1,102 citations

Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus

1996 • 1,024 citations

Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis.

1991 • 1,010 citations

Impaired Neurogenic and Endothelium-Mediated Relaxation of Penile Smooth Muscle from Diabetic Men with Impotence

1989 • 960 citations

Impaired endothelium-dependent and independent vasodilation in patients with Type 2 (non-insulin-dependent) diabetes mellitus

1992 • 922 citations

Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.

1996 • 884 citations

Hydroxyl radical production and autoxidative glycosylation. Glucose autoxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and ageing

1988 • 787 citations

The power of words.

1951 • 744 citations

Superoxide and peroxynitrite inatherosclerosis.

1994 • 674 citations

Magnitude and determinants of coronary artery disease in juvenile-onset, insulin-dependent diabetes mellitus

1987 • 671 citations

Free radicals mediate endothelial cell dysfunction caused by elevated glucose

1992 • 566 citations

Antioxidant Vitamin C Improves Endothelial Dysfunction in Chronic Smokers

1996 • 563 citations

Autoxidative Glycosylation and Possible Involvement of Peroxides and Free Radicals in LDL Modification by Glucose

1990 • 561 citations

Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes.

1992 • 527 citations

Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta.

1990 • 527 citations

Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans.

1994 • 518 citations

Chronic treatment with polyethylene-glycolated superoxide dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbits.

1991 • 403 citations

Oxygen-derived free radicals, endothelium, and responsiveness of vascular smooth muscle

1986 • 380 citations

Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta.

1990 • 375 citations

Prevention and Treatment of the Complications of Diabetes Mellitus

1995 • 366 citations

Release of intact endothelium-derived relaxing factor depends on endothelial superoxide dismutase activity

1991 • 322 citations

Diabetes and the risk of stroke. The Honolulu Heart Program

1987 • 292 citations

Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta

1991 • 283 citations

Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification. Anti- rather than prooxidant activity of vitamin C in the presence of transition metal ions.

1993 • 278 citations

Influence of diabetes on mortality in acute myocardial infarction: Data from the GISSI-2 study

1993 • 269 citations

Contraction of diabetic rabbit aorta caused by endothelium-derived PGH2-TxA2

1989 • 245 citations

Low-dose alpha-tocopherol improves and high-dose alpha-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits.

1994 • 229 citations

Impaired antioxidant status in diabetic rat liver

1993 • 216 citations

Inhibition of Nitric Oxide Synthesis in Forearm Vasculature of Insulin-Dependent Diabetic Patients: Blunted Vasoconstriction in Patients with Microalbuminuria

1993 • 214 citations

Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits.

1993 • 204 citations

Diabetes and the Risk of Stroke

1987 • 203 citations

Endothelial dysfunction in mesenteric resistance arteries of diabetic rats: role of free radicals

1994 • 198 citations

Dietary Correction of Hypercholesterolemia in the Rabbit Normalizes Endothelial Superoxide Anion Production

1995 • 197 citations

Ascorbic acid metabolism in diabetes mellitus

1981 • 194 citations

Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels.

1991 • 191 citations

Diabetic Retinopathy

1990 • 180 citations

Mechanism of impaired responses of cerebral arterioles during diabetes mellitus

1991 • 179 citations

Increased Superoxide Production by Mononuclear Cells of Patients With Hypertriglyceridemia and Diabetes

1988 • 166 citations

Regulation of spontaneous EDRF release in diabetic rat aorta by oxygen free radicals

1992 • 161 citations

Topical hyperglycemia rapidly suppresses EDRF-mediated vasodilation of normal rat arterioles

1993 • 144 citations

Diabetes and the risk of stroke

1993 • 133 citations

Evidence of Polymorphonuclear Neutrophils (PMN) Activation in Patients With Insulin-Dependent Diabetes Mellitus

1987 • 131 citations

Repeat percutaneous transluminal coronary angioplasty and predictors of recurrent restenosis

1989 • 124 citations

Vitamin C metabolites and microangiopathy in diabetes mellitus.

1987 • 101 citations

The Contribution of Non—Insulin-Dependent Diabetes to Lower-Extremity Amputation in the Community

1994 • 99 citations

Reduced mononuclear leukocyte ascorbic acid content in adults with insulin-dependent diabetes mellitus consuming adequate dietary vitamin C

1991 • 96 citations

Impaired endothelium‐dependent relaxation in isolated resistance arteries of spontaneously diabetic rats

1995 • 91 citations

Structural and functional origins of suppressed acetylcholine vasodilation in diabetic rat intestinal arterioles.

1991 • 83 citations

Ascorbic Acid Metabolism and Polyol Pathway in Diabetes

1989 • 83 citations

Hyperglycemia-induced Intracellular Depletion of Ascorbic Acid in Human Mononuclear Leukocytes

1983 • 76 citations

Estimation of dehydroascorbic acid in blood of diabetic patients

1979 • 75 citations

Decreased susceptibility of liver mitochondria from diabetic rats to oxidative damage and associated increase in α-tocopherol

1993 • 73 citations

Formation of an F2-isoprostane in vascular smooth muscle cells by elevated glucose and growth factors

1996 • 51 citations

Elevated glucose alters eicosanoid release from porcine aortic endothelial cells.

1988 • 48 citations

Blood Dehydroascorbic Acid and Diabetes Mellitus in Human Beings

1982 • 44 citations

Modulators of free radical activity in diabetes mellitus: Role of ascorbic acid

1992 • 38 citations

The measurement of dehydroascorbic acid and diketogulonic acid in normal and diabetic plasma

1975 • 27 citations