High Glucose Increases Nitric Oxide Synthase Expression and Superoxide Anion Generation in Human Aortic Endothelial Cells

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Diabetes and cardiovascular disease. The Framingham study

1979 • 4,047 citations

Role of Oxidative Stress in Development of Complications in Diabetes

1991 • 3,774 citations

Induction of calcium-dependent nitric oxide synthases by sex hormones.

1994 • 1,074 citations

Impaired Neurogenic and Endothelium-Mediated Relaxation of Penile Smooth Muscle from Diabetic Men with Impotence

1989 • 960 citations

Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression.

1994 • 941 citations

Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene

1993 • 881 citations

The microestimation of succinate and the extinction coefficient of cytochrome c

1959 • 751 citations

Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.

1992 • 748 citations

Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.

1992 • 743 citations

Free radicals mediate endothelial cell dysfunction caused by elevated glucose

1992 • 566 citations

Molecular cloning and characterization of human endothelial nitric oxide synthase

1992 • 494 citations

Native Low-Density Lipoprotein Increases Endothelial Cell Nitric Oxide Synthase Generation of Superoxide Anion

1995 • 479 citations

Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C.

1991 • 429 citations

Free radicals in diabetic endothelial cell dysfunction

1994 • 398 citations

Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta.

1990 • 375 citations

Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications.

1989 • 374 citations

Up‐regulation of nitric oxide synthase by estradiol in human aorticendothelial cells

1995 • 352 citations

Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells.

1995 • 331 citations

Oxygen metabolites stimulate thromboxane production and vasoconstriction in isolated saline-perfused rabbit lungs.

1984 • 219 citations

The formation of peroxynitrite in vivo from nitric oxide and superoxide

1995 • 197 citations

High <scp>D</scp>-Glucose–Induced Changes in Endothelial Ca2+/EDRF Signaling are Due to Generation of Superoxide Anions

1996 • 136 citations

Stimulation of de novo synthesis of prostaglandin G/H synthase in human endothelial cells by phorbol ester.

1988 • 132 citations

Oxidant- and lipid-induced pulmonary vasoconstriction mediated by arachidonic acid metabolites

1983 • 77 citations

Hyperglycemia, Diabetes, and Vascular Disease

1992 • 73 citations

Transmural pressure inhibits nitric oxide release from human endothelial cells

1992 • 71 citations

Production of arachidonic acid metabolites by endothelial cells in hyperoxia

1986 • 32 citations

Diabetes Mellitus and the Vascular Endothelium

1992 • 17 citations