Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug.

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Superoxide Dismutase

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Should We STOP Angiotensin Converting Enzyme Inhibitors/Angiotensin Receptor Blockers in Advanced Kidney Disease?

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A Comparison of Enalapril with Hydralazine–Isosorbide Dinitrate in the Treatment of Chronic Congestive Heart Failure

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Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

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Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

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Effect of Vasodilator Therapy on Mortality in Chronic Congestive Heart Failure

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Hypercholesterolemia increases endothelial superoxide anion production.

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Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance.

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The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase

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NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium

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Prevention and Reversal of Nitrate Tolerance in Patients with Congestive Heart Failure

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Agonist-Induced Peroxynitrite Production from Endothelial Cells

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Sites of superoxide anion production detected by lucigenin in calf pulmonary artery smooth muscle

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Effect of Vasodilator Therapy on Mortality in Chronic Congestive Heart Failure. Results of a Veterans Administration Cooperative Study

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Concurrent hydralazine administration prevents nitroglycerin-induced hemodynamic tolerance in experimental heart failure.

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Hydralazine: A potent inhibitor of aldehyde oxidase activity in vitro and in vivo

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A Reappraisal of Nitrate Therapy

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Pharmacology and Structure-Activity Relationships for KATP Modulators

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Comparison of hemodynamic effects and plasma cyclic guanosine monophosphate of nicorandil and nitroglycerin in patients with congestive heart failure

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Prevention and Reversal of Nitrate Tolerance in Patients with Congestive Heart Failure

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Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10-enzymes by clinically used anti-hypertensive drugs.

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Effect of hydralazine on tension and membrane potential in the rat caudal artery.

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A reappraisal of nitrate therapy

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