NF-κB modulation and ionizing radiation: mechanisms and future directions for cancer treatment

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

Activators and Target Genes of Rel/NF-кB Transcription Factors

2003 • 3,164 citations

NF-κB: Ten Years After

1996 • 3,008 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

IAP family proteins---suppressors of apoptosis

1999 • 2,570 citations

NF-κB in cancer: from innocent bystander to major culprit

2002 • 2,457 citations

NF-κB functions as a tumour promoter in inflammation-associated cancer

2004 • 2,370 citations

IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer

2004 • 2,361 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

Mitochondria as the central control point of apoptosis

2000 • 1,875 citations

TNF-R1 Signaling: A Beautiful Pathway

2002 • 1,860 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Inhibition of NF-κB by Sodium Salicylate and Aspirin

1994 • 1,743 citations

Therapeutic potential of inhibition of the NF-κB pathway in the treatment of inflammation and cancer

2001 • 1,548 citations

Activation of Transcription Factor NF-κB Is Suppressed by Curcumin (Diferuloylmethane)

1995 • 1,352 citations

NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1

1999 • 1,282 citations

Control of apoptosis by Rel/NF-κB transcription factors

1999 • 1,204 citations

Phosphorylation of NF-κB p65 by PKA Stimulates Transcriptional Activity by Promoting a Novel Bivalent Interaction with the Coactivator CBP/p300

1998 • 1,200 citations

How NF-κB is activated: the role of the IκB kinase (IKK) complex

1999 • 1,133 citations

Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B.

1996 • 1,125 citations

Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene

1999 • 978 citations

NF-κB as a Therapeutic Target in Multiple Myeloma

2002 • 906 citations

Oxidative stress and nuclear factor-κB activation

2000 • 865 citations

Structure of an IκBα/NF-κB Complex

1998 • 792 citations

Molecular Control of Immune/Inflammatory Responses: Interactions Between Nuclear Factor-κB and Steroid Receptor-Signaling Pathways

1999 • 785 citations

The development of proteasome inhibitors as anticancer drugs

2004 • 768 citations

To be, or not to be: NF-κB is the answer – role of Rel/NF-κB in the regulation of apoptosis

2003 • 738 citations

Role of NF-κB in p53-mediated programmed cell death

2000 • 730 citations

Tyrosine Phosphorylation of IκB-α Activates NF-κB without Proteolytic Degradation of IκB-α

1996 • 665 citations

Activation of Phosphatidylinositol 3-Kinase in Response to Interleukin-1 Leads to Phosphorylation and Activation of the NF-κB p65/RelA Subunit

1999 • 650 citations

The Beginning of the End: IκB Kinase (IKK) and NF-κB Activation

1999 • 635 citations

Tumor necrosis factor receptor-associated factors (TRAFs)—a family of adapter proteins that regulates life and death

1998 • 597 citations

NF-κB Inducers Upregulate cFLIP, a Cycloheximide-Sensitive Inhibitor of Death Receptor Signaling

2001 • 583 citations

Structure of NF-κB p50 homodimer bound to a κB site

1995 • 564 citations

Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras

1997 • 547 citations

The oncoprotein Bcl-3 directly transactivates through κB motifs via association with DNA-binding p50B homodimers

1993 • 506 citations

At the Crossroads of Inflammation and Cancer

2004 • 496 citations

Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation.

1989 • 473 citations

Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements.

1992 • 449 citations

The Rel/NF-κB signal transduction pathway: introduction

1999 • 436 citations

NF-κB and Rel Proteins in Innate Immunity

1995 • 435 citations

Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms

1998 • 431 citations

NF-κB transcription factor induces drug resistance through MDR1 expression in cancer cells

2003 • 409 citations

Two Pathways to NF-κB

2002 • 383 citations

Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects?

2001 • 371 citations

Bridging the Gap: Composition, Regulation, and Physiological Function of the IκB Kinase Complex

1999 • 324 citations

Enhancement of radiosensitivity by proteasome inhibition: Implications for a role of NF-κB

2001 • 323 citations

Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3

2004 • 299 citations

Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-κB activation

1999 • 285 citations

Sanguinarine (Pseudochelerythrine) Is a Potent Inhibitor of NF-κB Activation, IκBα Phosphorylation, and Degradation

1997 • 281 citations

ATM: A mediator of multiple responses to genotoxic stress

1999 • 274 citations

Inhibition of NF-kappa B cellular function via specific targeting of the Ikappa B-ubiquitin ligase

1997 • 238 citations

Molecular Control of Immune/Inflammatory Responses: Interactions Between Nuclear Factor- B and Steroid Receptor-Signaling Pathways

1999 • 215 citations

CREB-binding Protein Is a Nuclear Integrator of Nuclear Factor-κB and p53 Signaling

1999 • 192 citations

IκB-kinaseβ-dependent NF-κB activation provides radioprotection to the intestinal epithelium

2004 • 184 citations

Proteasome inhibition: a novel approach to cancer therapy

2002 • 183 citations

Acute induction of inflammatory cytokine expression after γ-irradiation in the rat: Effect of an NF-κB inhibitor

2004 • 179 citations

The oncoprotein Bcl-3 can facilitate NF-kappa B-mediated transactivation by removing inhibiting p50 homodimers from select kappa B sites.

1993 • 177 citations

The ATM protein is required for sustained activation of NF-κB following DNA damage

1999 • 176 citations

High expression levels of nuclear factor κB, IκB kinase α and Akt kinase in squamous cell carcinoma of the oral cavity

2001 • 160 citations

p53-mediated repression of nuclear factor-kappaB RelA via the transcriptional integrator p300.

1998 • 158 citations

Nuclear Localization of IκBα Is Mediated by the Second Ankyrin Repeat: the IκBα Ankyrin Repeats Define a Novel Class of cis-Acting Nuclear Import Sequences

1998 • 142 citations

High expression levels of nuclear factor ?B, I?B kinase ? and Akt kinase in squamous cell carcinoma of the oral cavity

2001 • 142 citations

Activation of nuclear factor kappaB through the IKK complex by the topoisomerase poisons SN38 and doxorubicin: a brake to apoptosis in HeLa human carcinoma cells.

2001 • 133 citations

A novel ionizing radiation-induced signaling pathway that activates the transcription factor NF-κB

1998 • 132 citations

pRb and the Cdks in apoptosis and the cell cycle

1998 • 127 citations

Cellular responses to ionizing radiation damage

2001 • 124 citations

ATM and the Catalytic Subunit of DNA-Dependent Protein Kinase Activate NF-κB through a Common MEK/Extracellular Signal-Regulated Kinase/p90^rsk Signaling Pathway in Response to Distinct Forms of DNA Damage

2004 • 124 citations

CD95 (Fas)-induced caspase-mediated proteolysis of NF-kappaB.

1998 • 123 citations

Inhibition of the NF-κB transcription factor increases Bax expression in cancer cell lines

2001 • 122 citations

Tumor necrosis factor-alpha sensitizes prostate cancer cells to gamma-irradiation-induced apoptosis.

1999 • 115 citations

The DNA-Dependent Protein Kinase Participates in the Activation of NFκB Following DNA Damage

1998 • 113 citations

Blocking Caspase-3-Mediated Proteolysis of IKKβ Suppresses TNF-α-Induced Apoptosis

2001 • 107 citations

NF-κB activation in response to toxical and therapeutical agents: role in inflammation and cancer treatment

2000 • 103 citations

Activation of nuclear factor kappaB in radioresistance of TP53-inactive human keratinocytes.

2002 • 102 citations

Inhibition of NF- B, Clonogenicity, and Radiosensitivity of Human Cancer Cells

1999 • 97 citations

Enhanced radiosensitivity by inhibition of nuclear factor kappaB activation in human malignant glioma cells

1997 • 94 citations

Cisplatin and radiation sensitivity in human head and neck squamous carcinomas are independently modulated by glutathione and transcription factor NF-?B

2000 • 89 citations

Stable inhibition of nuclear factor kappaB in cancer cells does not increase sensitivity to cytotoxic drugs.

1999 • 88 citations

Apoptosis and radiosensitization of Hodgkin cells by proteasome inhibition

2000 • 86 citations

NF-κB signaling pathway as a target for human tumor radiosensitization

2001 • 85 citations

Coordinate modulation of Sp1, NF‐kappa B, and p53 in confluent human malignant melanoma cells after ionizing radiation

2000 • 78 citations

A high dose of ionizing radiation induces tissue-specific activation of nuclear factor-kappaB in vivo.

1999 • 74 citations

The role of constitutive NF-kappaB activity in PC-3 human prostate cancer cell invasive behavior.

2000 • 74 citations

Ataxia-telangiectasia: a multifaceted genetic disorder associated with defective signal transduction

1996 • 67 citations

Phosphorylation of NF-KB1-p50 is involved in NF-kappa B activation and stable DNA binding.

1994 • 66 citations

Indomethacin-induced radiosensitization and inhibition of ionizing radiation-induced NF-kappaB activation in HeLa cells occur via a mechanism involving p38 MAP kinase.

2001 • 66 citations

A High Dose of Ionizing Radiation Induces Tissue-Specific Activation of Nuclear Factor-κB In Vivo

1999 • 64 citations

Blocking NF-κB activation in Jurkat leukemic T cells converts the survival agent and tumor promoter PMA into an apoptotic effector

2002 • 52 citations

Tyrosine Phosphorylation of IkB-a Activates NF-kB without Proteolytic Degradation of IkB-a

1996 • 49 citations

NF-κB/Rel family members are physically associated phosphoproteins

1994 • 46 citations

Inhibition of radiation-induced nuclear factor-kappaB activation by an anti-Ras single-chain antibody fragment: lack of involvement in radiosensitization.

2002 • 41 citations

Radiation-induced Activation of Nuclear Factor-κB Involves Selective Degradation of Plasma Membrane-associated IκBα

2002 • 34 citations

NF?B activity and target gene expression in the rat brain after one and two exposures to ionizing radiation

1999 • 32 citations

Failure of a Second X-ray Dose to Activate Nuclear Factor κB in Normal Rat Astrocytes

1997 • 32 citations

Transcriptional activation of TRADD mediates p53-independent radiation-induced apoptosis of glioma cells

2001 • 31 citations

Constitutive NF-κB activity influences basal apoptosis and radiosensitivity of head-and-neck carcinoma cell lines

2001 • 31 citations

Membrane-derived second messenger regulates x-ray-mediated tumor necrosis factor alpha gene induction.

1994 • 30 citations

High constitutive level of NF-κB is crucial for viability of adenocarcinoma cells

2001 • 23 citations

Nuclear factor kappaB cooperates with c-Myc in promoting murine hepatocyte survival in a manner independent of p53 tumor suppressor function.

1999 • 16 citations

CD40 and B Chronic Lymphocytic Leukemia Cell Response To Fludarabine: The Influence of NF-kB/Rel Transcription Factors On Chemotherapy-Induced Apoptosis

2000 • 14 citations

Deleted Work

1955 • 0 citations