The DNA-Dependent Protein Kinase Participates in the Activation of NFκB Following DNA Damage

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

NF-κB: Ten Years After

1996 • 3,008 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 • 2,048 citations

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

1993 • 1,219 citations

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

1997 • 1,198 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

Absence of p350 Subunit of DNA-Activated Protein Kinase from a Radiosensitive Human Cell Line

1995 • 530 citations

Ionizing radiation induces expression and binding activity of the nuclear factor kappa B.

1991 • 410 citations

A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-kappa B.

1995 • 402 citations

DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK

1995 • 344 citations

When is a lipid kinase not a lipid kinase? When it is a protein kinase

1995 • 315 citations

A DNA-activated protein kinase from HeLa cell nuclei.

1990 • 285 citations

REL/NF-κB/IκB Story

1995 • 278 citations

Functional interaction between DNA-PK and c-Abl in response to DNA damage

1997 • 254 citations

Physical Interaction between Epidermal Growth Factor Receptor and DNA-dependent Protein Kinase in Mammalian Cells

1998 • 229 citations

Role of Unphosphorylated, Newly Synthesized IκBβ in Persistent Activation of NF-κB

1996 • 228 citations

Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay.

1997 • 215 citations

Increases in sequence specific DNA binding by p53 following treatment with chemotherapeutic and DNA damaging agents.

1993 • 201 citations

Casein Kinase II Phosphorylates IκBα at S-283, S-289, S-293, and T-291 and Is Required for Its Degradation

1996 • 187 citations

Distinct Functional Properties of IκBα and IκBβ

1997 • 166 citations

Basal Phosphorylation of the PEST Domain in IκBβ Regulates Its Functional Interaction with the c-rel Proto-Oncogene Product

1996 • 91 citations

ATM gene product phosphorylates I kappa B-alpha.

1997 • 79 citations

Postinduction transcriptional repression of E-selectin and vascular cell adhesion molecule-1.

1996 • 46 citations

Cdk2 kinase phosphorylates serine 315 of human p53 in vitro.

1995 • 43 citations