Inhibition of NF-kappa B cellular function via specific targeting of the Ikappa B-ubiquitin ligase

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

NF-κB: Ten Years After

1996 • 3,008 citations

β-catenin is a target for the ubiquitin–proteasome pathway

1997 • 2,461 citations

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

THE UBIQUITIN SYSTEM FOR PROTEIN DEGRADATION

1992 • 1,402 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

How Proteolysis Drives the Cell Cycle

1996 • 1,277 citations

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

1997 • 1,215 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity

1996 • 960 citations

The Transcriptional Activity of NF-κB Is Regulated by the IκB-Associated PKAc Subunit through a Cyclic AMP–Independent Mechanism

1997 • 820 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†

1996 • 717 citations

Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway

1997 • 712 citations

Coupling of a Signal Response Domain in IκBα to Multiple Pathways for NF-κB Activation

1995 • 706 citations

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination.

1995 • 558 citations

The N-end rule

1992 • 464 citations

Inducible Nuclear Expression of Newly Synthesized IκBα Negatively Regulates DNA-Binding and Transcriptional Activities of NF-κB

1995 • 442 citations

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.

1995 • 438 citations

I kappa B epsilon, a novel member of the Ikappa B family, controls RelA and cRel NF-kappa B activity

1997 • 394 citations

Activation of NF-kappa B in vivo is regulated by multiple phosphorylations.

1994 • 362 citations

The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms.

1993 • 361 citations

The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression

1995 • 354 citations

In vivo control of NF-kappa B activation by I kappa B alpha.

1993 • 326 citations

Activation of the transcription factor nuclear factor‐κB in human inflamed synovial tissue

1996 • 314 citations

Cdc53 Targets Phosphorylated G1 Cyclins for Degradation by the Ubiquitin Proteolytic Pathway

1996 • 306 citations

Ubiquitin-dependent Degradation of Certain Protein Substrates in Vitro Requires the Molecular Chaperone Hsc70

1997 • 294 citations

p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction.

1993 • 291 citations

Selective protein degradation: A journey's end within the proteasome

1995 • 259 citations

Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase.

1995 • 201 citations

Selective inhibition of E-selectin, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 expression by inhibitors of I kappa B-alpha phosphorylation.

1995 • 190 citations

Critical Role for Lysines 21 and 22 in Signal-induced, Ubiquitin-mediated Proteolysis of IkB-α

1996 • 182 citations

Involvement of the Molecular Chaperone Ydj1 in the Ubiquitin-Dependent Degradation of Short-Lived and Abnormal Proteins in Saccharomyces cerevisiae

1996 • 153 citations

Both Amino- and Carboxyl-Terminal Sequences within IκBα Regulate Its Inducible Degradation

1996 • 153 citations

Structure and Functions of the 20S and 26S Proteasomes

1996 • 137 citations

The Ubiquitin System for Protein Degradation

1992 • 97 citations

Make it or break it: the role of ubiquitin-dependent proteolysis in cellular regulation

1995 • 83 citations

T Cell Antigen Receptor Ubiquitination Is a Consequence of Receptor-mediated Tyrosine Kinase Activation

1996 • 83 citations

Purification and characterization of a novel species of ubiquitin-carrier protein, E2, that is involved in degradation of non-“N-end rule” protein substrates

1994 • 66 citations

The self-destructive personality of a cell cycle in transition

1995 • 64 citations

Uncoupling ubiquitin-protein conjugation from ubiquitin-dependent proteolysis by use of .beta.,.gamma.-nonhydrolyzable ATP analogs

1991 • 43 citations

Cell cycle: Cull and destroy

1996 • 36 citations

Ubiquitin–mediated proteolysis and male sterility

1996 • 13 citations