Transcriptional activation of TRADD mediates p53-independent radiation-induced apoptosis of glioma cells

Identification and characterization of a new member of the TNF family that induces apoptosis

1995 • 2,890 citations

Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo

1999 • 2,494 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family

1996 • 1,793 citations

The Receptor for the Cytotoxic Ligand TRAIL

1997 • 1,755 citations

Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors

1997 • 1,694 citations

An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL

1997 • 1,506 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

1996 • 1,001 citations

A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen

1993 • 857 citations

Induction of NF-κB by the Akt/PKB kinase

1999 • 847 citations

FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

1996 • 780 citations

Regulation ofp53downstream genes

1998 • 777 citations

Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.

1997 • 749 citations

Wild-Type Human p53 and a Temperature-Sensitive Mutant Induce Fas/APO-1 Expression

1995 • 736 citations

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.

1994 • 596 citations

Modulation of life and death by the TNF receptor superfamily

1998 • 543 citations

Intrinsic radiosensitivity of human cell lines is correlated with radioresponsiveness of human tumors: Analysis of 101 published survival curves

1985 • 488 citations

The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells.

1997 • 456 citations

Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis

1997 • 286 citations

Radiation therapy of brain tumors

1977 • 249 citations

Apoptosis and Its Role in Human Disease

1994 • 232 citations

Apoptosis in small intestinal epithelia from p53-null mice: evidence for a delayed, p53-indepdendent G2/M-associated cell death after γ-irradiation

1997 • 211 citations

Suppression of Ras-Induced Apoptosis by the Rac GTPase

1999 • 177 citations

Computer Programs for the Analysis of Cellular Survival Data

1987 • 171 citations

CYCLIN B EXPRESSION IN HELA CELLS DURING THE G2 BLOCK INDUCED BY IONIZING RADIATION

1991 • 165 citations

c-Jun-Dependent CD95-L Expression Is a Rate-Limiting Step in the Induction of Apoptosis by Alkylating Agents

2000 • 159 citations

Activation of the CD95 (APO-1/Fas) system in T cells from human immunodeficiency virus type-1-infected children

1996 • 150 citations

Activation of protein kinase C δ by the c-Abl tyrosine kinase in response to ionizing radiation

1998 • 148 citations

Cell Cycle-regulated Expression, Phosphorylation, and Degradation of p55Cdc

1997 • 125 citations

The Cell Cycle-Coupled Expression of Topoisomerase IIα during S Phase Is Regulated by mRNA Stability and Is Disrupted by Heat Shock or Ionizing Radiation

1996 • 121 citations

Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-kappa B activation

1997 • 113 citations

p53-Dependent G1 arrest and p53-independent apoptosis influence the radiobiologic response of glioblastoma

1996 • 104 citations

In vitro intrinsic radiation sensitivity of glioblastoma multiforme

1992 • 104 citations

C-MYC–induced Apoptosis in Polycystic Kidney Disease Is Bcl-2 and p53 Independent

1997 • 91 citations

Unbound states by analytic continuation in the coupling constant

1999 • 79 citations

Radiation Therapy and Hydroxyurea Followed by the Combination of 6-Thioguanine and BCNU for the Treatment of Primary Malignant Brain Tumors

1998 • 72 citations

Constitutional p53 mutations associated with brain tumors in young adults

1995 • 72 citations

Cyclin A Is a Functional Target of Retinoblastoma Tumor Suppressor Protein-mediated Cell Cycle Arrest

1999 • 72 citations

Irradiation Induces WAF1 Expression through a p53-independent Pathway in KG-1 Cells

1995 • 71 citations

Down-regulation of cell cycle control genes by ionizing radiation.

1992 • 57 citations

Superfractionated radiotherapy in grade III, IV intracranial gliomas

1988 • 51 citations

p53-Oriented cancer therapies: Current progress

1999 • 51 citations

The effect of cycloheximide on natural and X-ray-induced cell death in the developing cerebral cortex

1992 • 40 citations

Generation of Astrocyte Cultures from Normal and Neoplastic Central Nervous System

1990 • 40 citations

Accentuated apoptosis in normally developing p53 knockout mouse embryos following genotoxic stress

1999 • 39 citations

A Novel DNA Damage Checkpoint Involving Post-transcriptional Regulation of Cyclin A Expression

2000 • 35 citations

Evidence of internucleosomal DNA fragmentation and identification of dying cells in X‐ray‐induced cell death in the developing brain

1995 • 30 citations

Signaling through the antigen receptor of B lymphocytes activates a p53-independent pathway of c-Myc-induced apoptosis

1999 • 24 citations

Effect of ionizing radiation on cell-cycle progression and cyclin B1 expression in human melanoma cells

1996 • 21 citations

The effects ofO 6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cells

1993 • 20 citations

Epithelial Cells of Different Organs Exhibit Distinct Patterns of p53-Dependent and p53-Independent Apoptosis Following DNA Insult

1999 • 20 citations

Genomic Organization, 5′ Flanking Enhancer Region, and Chromosomal Assignment of the Cell Cycle Gene, p55Cdc

1998 • 10 citations