Radiation-induced Activation of Nuclear Factor-κB Involves Selective Degradation of Plasma Membrane-associated IκBα

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

NF-κB: Ten Years After

1996 • 3,008 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Tyrosine Phosphorylation of IκB-α Activates NF-κB without Proteolytic Degradation of IκB-α

1996 • 665 citations

NF-kappa B activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase

1999 • 554 citations

Interleukin-10 Signaling Blocks Inhibitor of κB Kinase Activity and Nuclear Factor κB DNA Binding

1999 • 517 citations

Recruitment of the IKK Signalosome to the p55 TNF Receptor

2000 • 457 citations

Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues.

1994 • 449 citations

Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms

1998 • 431 citations

Ionizing radiation induces expression and binding activity of the nuclear factor kappa B.

1991 • 410 citations

Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liver.

1984 • 393 citations

Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.

1994 • 389 citations

Isolation of rat hepatocyte plasma membranes. I. Presence of the three major domains.

1983 • 306 citations

Regulated Commitment of TNF Receptor Signaling

1999 • 282 citations

Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo.

1999 • 265 citations

Nuclear Retention of IκBα Protects It from Signal-induced Degradation and Inhibits Nuclear Factor κB Transcriptional Activation

1999 • 232 citations

Role of Unphosphorylated, Newly Synthesized IκBβ in Persistent Activation of NF-κB

1996 • 228 citations

Reactive Oxygen Species Are Downstream Products of TRAF-mediated Signal Transduction

2001 • 196 citations

Differential IκB Kinase Activation and IκBα Degradation by Interleukin-1β and Tumor Necrosis Factor-α in Human U937 Monocytic Cells

1999 • 165 citations

Targeted Inactivation of the Isoprenylcysteine Carboxyl Methyltransferase Gene Causes Mislocalization of K-Ras in Mammalian Cells

2000 • 162 citations

IκB Is a Substrate for a Selective Pathway of Lysosomal Proteolysis

1998 • 143 citations

Activation of nuclear factor kappaB through the IKK complex by the topoisomerase poisons SN38 and doxorubicin: a brake to apoptosis in HeLa human carcinoma cells.

2001 • 133 citations

Induction of Nuclear Factor κB after Low-Dose Ionizing Radiation Involves a Reactive Oxygen Intermediate Signaling Pathway

1994 • 131 citations

IκB-α, the NF-κB Inhibitory Subunit, Interacts with ANT, the Mitochondrial ATP/ADP Translocator

2001 • 85 citations

Control of NF–κB transcriptional activation by signal induced proteolysis of IκBα

1999 • 84 citations

Localization of Endogenous Grb10 to the Mitochondria and Its Interaction with the Mitochondrial-associated Raf-1 Pool

1999 • 82 citations

12-O-Tetradecanoylphorbol-13-acetate Induces Epstein–Barr Virus Reactivation via NF-κB and AP-1 as Regulated by Protein Kinase C and Mitogen-Activated Protein Kinase

2001 • 68 citations

Nuclear Import of IκBα Is Accomplished by a Ran-Independent Transport Pathway

2000 • 64 citations

Inducible NF-κB Activation Is Permitted by Simultaneous Degradation of Nuclear IκBα

2000 • 57 citations

I kappa B alpha degradation is not a requirement for the X-ray-induced activation of nuclear factor kappa B in normal rat astrocytes and human brain tumour cells

1998 • 48 citations

Transient Nuclear Factor κB (NF-κB) Activation Stimulated by Interleukin-1β May Be Partly Dependent on Proteasome Activity, but Not Phosphorylation and Ubiquitination of the IκBα Molecule, in C6 Glioma Cells

1999 • 42 citations

E1A inhibition of radiation-induced NF-kappaB activity through suppression of IKK activity and IkappaB degradation, independent of Akt activation.

2001 • 41 citations

Inhibition of radiation-induced nuclear factor-kappaB activation by an anti-Ras single-chain antibody fragment: lack of involvement in radiosensitization.

2002 • 41 citations

Molecular Mechanisms of TNFα Cytotoxicity: Activation of NF-κB and Nuclear Translocation

1996 • 35 citations

TNF‐α dependent NF‐κB activation in cultured canine keratinocytes is partly mediated by reactive oxygen species

2001 • 34 citations

Subcellular Redistribution of HTLV-I Tax Protein by NF-κB/Rel Transcription Factors

1994 • 32 citations

Failure of a Second X-ray Dose to Activate Nuclear Factor κB in Normal Rat Astrocytes

1997 • 32 citations

Involvement of Different Transduction Pathways in NF-kB Activation by Several Inducers

1997 • 28 citations

Rapid isolation of plasmalemma from cultured A431 cells: Characterization of epidermal growth factor receptors

1988 • 8 citations