The role of constitutive NF-kappaB activity in PC-3 human prostate cancer cell invasive behavior.

Cancer statistics, 2000

2000 • 3,907 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

1995 • 1,715 citations

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.

1989 • 1,660 citations

Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

1996 • 1,555 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

The Role of Nuclear Factor- κ B in Cytokine Gene Regulation

1997 • 948 citations

Constitutive Activation of NF-κB during Progression of Breast Cancer to Hormone-Independent Growth

1997 • 824 citations

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.

1997 • 780 citations

Tyrosine Phosphorylation of IκB-α Activates NF-κB without Proteolytic Degradation of IκB-α

1996 • 665 citations

Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines

1992 • 530 citations

Synergistic upregulation of metalloproteinase‐9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF‐κB

1998 • 500 citations

Direct Phosphorylation of IκB by IKKα and IKKβ: Discrimination Between Free and NF-κB-Bound Substrate

1998 • 450 citations

Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude mice.

1996 • 365 citations

NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress.

1994 • 361 citations

THE MANY ROLES OF c-Myc IN APOPTOSIS

1998 • 310 citations

Constitutive Activation of NF-κB Causes Resistance to Apoptosis in Human Cutaneous T Cell Lymphoma HuT-78 Cells

1998 • 300 citations

A new in vitro assay for quantitating tumor cell invasion.

1989 • 297 citations

NF-κB to the rescue: RELs, apoptosis and cellular transformation

1999 • 276 citations

Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo.

1999 • 265 citations

Ablation of transplanted HTLV-I tax-transformed tumors in mice by antisense inhibition of NF-kappa B

1993 • 249 citations

Constitutive activation of NF-kappa B is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein.

1996 • 193 citations

Oxidative Stress Induces NF- B Nuclear Translocation Without Degradation of I B

1999 • 164 citations

Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA

1999 • 160 citations

Correlation of metastasis-related gene expression with metastatic potential in human prostate carcinoma cells implanted in nude mice using an in situ messenger RNA hybridization technique.

1997 • 155 citations

Both Amino- and Carboxyl-Terminal Sequences within IκBα Regulate Its Inducible Degradation

1996 • 153 citations

Enhanced degradation of I-kappaB alpha contributes to endogenous activation of NF-kappaB in Hs294T melanoma cells.

1997 • 143 citations

Specific alterations in the expression of ?3?1 and ?6?4 integrins in highly invasive and metastatic variants of human prostate carcinoma cells selected by in vitro invasion through reconstituted basement membrane

1993 • 129 citations

Effect of human T-cell leukemia virus type I tax protein on activation of the human vimentin gene

1990 • 124 citations

Structural alterations of the NF-kappa B transcription factor lyt-10 in lymphoid malignancies.

1993 • 106 citations

AN ESSENTIAL ROLE FOR NUCLEAR FACTOR KAPPA B IN PREVENTING TNF-alpha-INDUCED CELL DEATH IN PROSTATE CANCER CELLS

1999 • 105 citations

Cooperation Between Transcription Factor AP-1 and NF-kappa B in the Induction of Interleukin-8 in Human Pancreatic Adenocarcinoma Cells by Hypoxia

1999 • 100 citations

bcl-2 over-expression enhances NF-?B activity and induces mmp-9 transcription in human MCF7ADR breast-cancer cells

2000 • 97 citations

Activation of nuclear factor-kappa B in human metastatic melanomacells and the effect of oxidative stress.

1999 • 96 citations

Identification of a new serine kinase that activates NF kappa B by direct phosphorylation.

1993 • 96 citations

Anoxia-Induced Up-Regulation of Interleukin-8 in Human Malignant Melanoma

1999 • 94 citations

Extracellular Tax1 protein stimulates tumor necrosis factor-beta and immunoglobulin kappa light chain expression in lymphoid cells

1992 • 87 citations

Paclitaxel up-regulates interleukin-8 synthesis in human lung carcinoma through an NF-κB- and AP-1-dependent mechanism

2000 • 82 citations

Phosphorylation of p105 PEST Sequences via a Redox-insensitive Pathway Up-regulates Processing to p50 NF-κB

1996 • 78 citations

Nuclear factor NF-kappa B can interact functionally with its cognate binding site to provide lymphoid-specific promoter function.

1988 • 77 citations

Alpha‐Melanocyte‐Stimulating Hormone Modulates Activation of NF‐κB and AP‐1 and Secretion of Interleukin‐8 in Human Dermal Fibroblasts

1999 • 69 citations

Involvement of proteasomes in migration and matrix metalloproteinase-9 production of oral squamous cell carcinoma

1998 • 65 citations

Negative Regulation of Transactivation Function but Not DNA Binding of NF-κB and AP-1 by IκBβ1 in Breast Cancer Cells

1999 • 65 citations

Purification and identification of chemokines potentially involved in kidney-specific metastasis by a murine lymphoma variant: induction of migration and NFκB activation

1998 • 59 citations

Activation of oncogenicity of the c-rel proto-oncogene.

1986 • 57 citations

Nuclear expression of the 50- and 65-kD Rel-related subunits of nuclear factor-kappa B is differentially regulated in human monocytic cells.

1992 • 56 citations

Expression of the v-rel oncogene in reticuloendotheliosis virus-transformed fibroblasts

1988 • 50 citations

The Signal Response of IκBα Is Regulated by Transferable N- and C-Terminal Domains

1997 • 46 citations

Human T-cell lymphotropic virus type 1 Tax1 activation of NF-kappa B: involvement of the protein kinase C pathway

1996 • 33 citations

Protein kinase C–dependent activation of NF-κB in enterocytes is independent of IκB degradation

1999 • 33 citations

Activation of Oncogenicity of the c-rel Proto-Oncogene

1986 • 20 citations

Coordinate Induction of IKBαand NFKB Genes

1994 • 17 citations

A DNA motif present in alpha V integrin promoter exhibits dual binding preference to distinct transcription factors.

1995 • 14 citations