Nuclear Localization of IκBα Is Mediated by the Second Ankyrin Repeat: the IκBα Ankyrin Repeats Define a Novel Class of cis-Acting Nuclear Import Sequences

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

A short amino acid sequence able to specify nuclear location

1984 • 2,529 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals

1997 • 2,062 citations

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 • 2,048 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequence

1991 • 1,501 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

1997 • 1,198 citations

CRM1 is responsible for intracellular transport mediated by the nuclear export signal

1997 • 1,195 citations

Identification of a signal for rapid export of proteins from the nucleus

1995 • 1,186 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

Exportin 1 (Crm1p) Is an Essential Nuclear Export Factor

1997 • 1,144 citations

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

1993 • 1,141 citations

The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

1995 • 1,127 citations

Nucleocytoplasmic Transport

1996 • 1,071 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

Nucleocytoplasmic transport: signals, mechanisms and regulation

1997 • 987 citations

The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors.

1993 • 819 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

1995 • 767 citations

Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity

1991 • 746 citations

I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention.

1992 • 731 citations

Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†

1996 • 717 citations

Evidence for a Role of CRM1 in Signal-Mediated Nuclear Protein Export

1997 • 716 citations

Isolation of a protein that is essential for the first step of nuclear protein import

1994 • 710 citations

Coupling of a Signal Response Domain in IκBα to Multiple Pathways for NF-κB Activation

1995 • 706 citations

A Novel Receptor-Mediated Nuclear Protein Import Pathway

1996 • 669 citations

Identification of different roles for RanGDP and RanGTP in nuclear protein import.

1996 • 644 citations

Structure of the p53 Tumor Suppressor Bound to the Ankyrin and SH3 Domains of 53BP2

1996 • 569 citations

A nuclear export signal in hnRNP A1: A signal-mediated, temperature-dependent nuclear protein export pathway

1995 • 529 citations

Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope

1995 • 511 citations

A nuclear localization domain in the hnRNP A1 protein.

1995 • 510 citations

The oncoprotein Bcl-3 directly transactivates through κB motifs via association with DNA-binding p50B homodimers

1993 • 506 citations

Distinct functions for the two importin subunits in nuclear protein import

1995 • 479 citations

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.

1995 • 477 citations

Synthetic peptides as nuclear localization signals

1986 • 472 citations

The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control

1990 • 469 citations

Inducible Nuclear Expression of Newly Synthesized IκBα Negatively Regulates DNA-Binding and Transcriptional Activities of NF-κB

1995 • 442 citations

Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins.

1995 • 430 citations

Nuclear localization of IκBα promotes active transport of NF-κB from the nucleus to the cytoplasm

1997 • 405 citations

Identification of Ets- and Notch-Related Subunits in GA Binding Protein

1991 • 358 citations

Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences

1995 • 337 citations

Promoter analysis of the gene encoding the I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B family.

1993 • 331 citations

Nuclear uptake control of NF-kappa B by MAD-3, an I kappa B protein present in the nucleus.

1993 • 330 citations

The candidate oncoprotein Bcl-3 is an antagonist of pSO/NF-κB-mediated inhibition

1992 • 325 citations

In vivo evidence for involvement of a 58 kDa component of nuclear pore-targeting complex in nuclear protein import.

1995 • 288 citations

Rel/NF-kappaB/IkappaB proteins and cancer.

1996 • 281 citations

Sequence and characterization of cytoplasmic nuclear protein import factor p97.

1995 • 274 citations

Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins.

1995 • 264 citations

Rel-Associated pp40: an Inhibitor of the Rel Family of Transcription Factors

1991 • 255 citations

Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes.

1995 • 254 citations

I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding.

1992 • 252 citations

cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates

1992 • 243 citations

Three NF-χB sites in the IχB-α promoter are required for induction of gene expression by TNFα

1994 • 219 citations

Identification of a Yeast Karyopherin Heterodimer That Targets Import Substrate to Mammalian Nuclear Pore Complexes

1995 • 210 citations

The NF-kappa B p50 precursor, p105, contains an internal I kappa B-like inhibitor that preferentially inhibits p50.

1992 • 178 citations

Distinct Functional Properties of IκBα and IκBβ

1997 • 166 citations

The p53-Binding Protein 53BP2 Also Interacts with Bcl2 and Impedes Cell Cycle Progression at G₂/M

1996 • 159 citations

High mutation rate of a spleen necrosis virus-based retrovirus vector.

1986 • 157 citations

Different localization of the product of the v-rel oncogene in chicken fibroblasts and spleen cells correlates with transformation by REV-T

1986 • 142 citations

Direct association of pp40/I kappa B beta with rel/NF-kappa B transcription factors: role of ankyrin repeats in the inhibition of DNA binding activity.

1992 • 140 citations

T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells.

1996 • 136 citations

v-rel oncoproteins in the nucleus and in the cytoplasm transform chicken spleen cells

1988 • 126 citations

The Pest-Like Sequence of IκBα Is Responsible for Inhibition of DNA Binding but Not for Cytoplasmic Retention of c-Rel or RelA Homodimers

1995 • 122 citations

Identification of lysine residues required for signal-induced ubiquitination and degradation of I kappa B-alpha in vivo.

1996 • 120 citations

A New Member of the IκB Protein Family, IκBε, Inhibits RelA (p65)-Mediated NF-κB Transcription

1997 • 119 citations

HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs

1996 • 106 citations

Cloning and expression of a chicken c-rel cDNA: unlike p59v-rel, p68c-rel is a cytoplasmic protein in chicken embryo fibroblasts.

1990 • 97 citations

Regulation of IκBβ in WEHI 231 Mature B Cells

1997 • 74 citations

The C terminus of the NF-χB p50 precursor and an IχB isoform contain transcription activation domains

1992 • 44 citations

I kappa B alpha can localize in the nucleus but shows no direct transactivation potential.

1993 • 41 citations

PEST-dependent cytoplasmic retention of v-Rel by I(kappa)B-alpha: evidence that I(kappa)B-alpha regulates cellular localization of c-Rel and v-Rel by distinct mechanisms

1996 • 16 citations

I kappa B-alpha-mediated inhibition of nuclear transport and DNA-binding by Rel proteins are separable functions: phosphorylation of C-terminal serine residues of I kappa B-alpha is specifically required for inhibition of DNA-binding.

1995 • 16 citations

Deleted Work

1955 • 0 citations