Interleukin-1 polymorphisms associated with increased risk of gastric cancer

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention.

1992 • 3,047 citations

α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

1998 • 2,898 citations

Estimates of the worldwide incidence of 25 major cancers in 1990

1999 • 2,103 citations

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

1998 • 1,546 citations

Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease

1998 • 1,460 citations

A Taql polymorphism in the human interleukin‐1β (IL‐1β) gene correlates with IL‐1β secretion in vitro

1992 • 923 citations

Cytokine gene polymorphism in human disease: on-line databases

1999 • 831 citations

Atrophic Gastritis andHelicobacter pyloriInfection in Patients with Reflux Esophagitis Treated with Omeprazole or Fundoplication

1996 • 786 citations

Both Familial Parkinson's Disease Mutations Accelerate α-Synuclein Aggregation

1999 • 695 citations

Pathology of Parkinson’s disease

1991 • 674 citations

Expanded Polyglutamine Protein Forms Nuclear Inclusions and Causes Neural Degeneration in Drosophila

1998 • 659 citations

Helicobacter pylori infection and chronic gastric acid hyposecretion

1997 • 646 citations

The Risk of Stomach Cancer in Patients with Gastric or Duodenal Ulcer Disease

1996 • 629 citations

Model Robust Confidence Intervals Using Maximum Likelihood Estimators

1986 • 593 citations

α-Synuclein Shares Physical and Functional Homology with 14-3-3 Proteins

1999 • 550 citations

Helicobacter pylori infection and abnormalities of acid secretion in patients with duodenal ulcer disease

1995 • 544 citations

Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1Ra) gene polymorphism

1995 • 543 citations

Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease.

1991 • 543 citations

Presence of the IL‐1RA Allele 2 (IL1RN*2) is Associated with Enhanced IL‐1β Production In Vitro

1998 • 543 citations

Mucosal Tumor Necrosis Factor-or, Interleukin-1/3, and Interleukin-8 Production in Patients with Helicobacter pylori Infection

1994 • 526 citations

Relationship between Helicobacter pylori iceA , cagA , and vacA Status and Clinical Outcome: Studies in Four Different Countries

1999 • 488 citations

Pathology and Biology of the Lewy Body

1993 • 394 citations

Aggregates from mutant and wild‐type α‐synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β‐sheet and amyloid‐like filaments

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The locus elav of Drosophila melanogaster is expressed in neurons at all developmental stages

1988 • 351 citations

Increased prevalence of precancerous changes in relatives of gastric cancer patients: Critical role of H. pylori

2000 • 330 citations

Science, medicine, and the future: Helicobacter pylori and gastric diseases

1998 • 302 citations

Interleukin 1β and tumour necrosis factor α inhibit acid secretion in cultured rabbit parietal cells by multiple pathways

1998 • 280 citations

Functional and ethnic association of allele 2 of the interleukin-1 receptor antagonist gene in ulcerative colitis

1999 • 212 citations

An Analysis of Linkage Disequilibrium in the Interleukin-1 Gene Cluster, Using a Novel Grouping Method for Multiallelic Markers

1998 • 182 citations

Secretagogue-specific effects of interleukin-1 on gastric acid secretion

1991 • 164 citations

Imbalance of the interleukin 1 system in colonic mucosa—association with intestinal inflammation and interleukin 1 receptor agonist genotype 2

1997 • 160 citations

Defective Glia in the Drosophila Brain Degeneration Mutant drop-dead

1993 • 158 citations

Vitamin C concentration in gastric juice before and after anti-Helicobacter pylori treatment.

1994 • 131 citations

Helicobacter pylori induces an array of pro‐inflammatory cytokines in human gastric epithelial cells: Quantification of mRNA for interleukin‐8, ‐1α/β, granulocyte‐macrophage colony‐stimulating factor, monocyte chemoattractant protein‐1 and tumour necrosis factor‐α

1997 • 130 citations

Development and distribution

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Distribution and Development

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Risk of stomach cancer in relation to consumption of cigarettes, alcohol, tea and coffee in Warsaw, Poland.

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On the relationship between senescence and age-related changes in two wild-type strains of Drosophila melanogaster

1978 • 117 citations

Temporal and Spatial Development of Serotonin and Dopamine Neurons in the Drosophila CNS

1994 • 105 citations

Gastric Cancer — A Long-Term Consequence ofHelicobacter pyloriInfection?

1994 • 104 citations

Helicobacter pylori infection enhances mucosal interleukin-1β, interleukin-6, and the soluble receptor of interleukin-2

1996 • 98 citations

Differential utilization of Janus kinase-signal transducer activator of transcription signaling pathways in the stimulation of human natural killer cells by IL-2, IL-12, and IFN-alpha.

1996 • 96 citations

Typing of HLA-DQA1 and DQB1 using DNA single-strand conformation polymorphism

1992 • 80 citations

Cytokine inhibition of gastric acid secretion—A little goes a long way

1992 • 79 citations

Pernicious Anaemia, Intragastric Bacterial Overgrowth, and Possible Consequences

1984 • 72 citations

The Structural Brain MutantVacuolar medullaofDrosophila melanogasterwith Specific Behavioral Defects and Cell Degeneration in the Adult

1986 • 59 citations

Hypergravity and Aging in <i>Drosophila melanogaster</i>

1996 • 54 citations

Perturbed pattern of catecholamine-containing neurons in mutant Drosophila deficient in the enzyme dopa decarboxylase

1986 • 44 citations