Constitutive Activation of NF-κB during Progression of Breast Cancer to Hormone-Independent Growth

Antibodies, a laboratory manual

1989 • 12,929 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

NF-κB: Ten Years After

1996 • 3,008 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

1996 • 1,555 citations

Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.

1990 • 1,510 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

The value of estrogen and progesterone receptors in the treatment of breast cancer

1980 • 735 citations

Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells.

1993 • 704 citations

12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region.

1987 • 699 citations

Repression of the Interleukin-6 Promoter by Estrogen Receptor Is Mediated by NF-κB and C/EBPβ

1995 • 692 citations

Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.

1993 • 639 citations

Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice.

1990 • 617 citations

Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells.

1996 • 604 citations

Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines

1992 • 530 citations

Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex

1990 • 486 citations

The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites.

1990 • 450 citations

TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence

1990 • 444 citations

The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties.

1989 • 428 citations

Hormones and mammary carcinogenesis in mice, rats, and humans: a unifying hypothesis.

1995 • 427 citations

Endocrine Treatment of Breast Cancer in Women

1990 • 403 citations

Urokinase and urokinase receptor: A paracrine/autocrine system regulating cell migration and invasiveness

1993 • 402 citations

The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins.

1991 • 380 citations

Negative Interaction between the RelA(p65) Subunit of NF-κB and the Progesterone Receptor

1996 • 353 citations

Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor.

1994 • 307 citations

Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death.

1994 • 304 citations

Changes in estrogen receptor, progesterone receptor, and pS2 expression in tamoxifen-resistant human breast cancer.

1995 • 297 citations

Urokinase-plasminogen activator, a marker for aggressive breast carcinomas. Preliminary report

1988 • 294 citations

IκBγ, a 70 kd protein identical to the C-terminal half of p110 NF-κB: A new member of the IκB family

1992 • 274 citations

Antisense inhibition of the p65 subunit of NF-kappa B blocks tumorigenicity and causes tumor regression.

1993 • 268 citations

MINIREVIEW: Estrogen Receptor Variants in Clinical Breast Cancer

1991 • 262 citations

Differentiation state and invasiveness of human breast cancer cell lines

1994 • 260 citations

Role of Unphosphorylated, Newly Synthesized IκBβ in Persistent Activation of NF-κB

1996 • 228 citations

Steroid receptors and other prognostic factors in primary breast cancer.

1988 • 227 citations

Association of MMP-2 Activation Potential With Metastatic Progression in Human Breast Cancer Cell Lines Independent of MMP-2 Production

1993 • 216 citations

Functional characterization of the NF-kappa B p65 transcriptional activator and an alternatively spliced derivative.

1992 • 177 citations

A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene.

1992 • 171 citations

Altered expression of estrogen-regulated genes in a tamoxifen-resistant and ICI 164,384 and ICI 182,780 sensitive human breast cancer cell line, MCF-7/TAMR-1.

1994 • 162 citations

Epidermal growth factor receptor (EGFr) as a marker for poor prognosis in node-negative breast cancer patients: Neu and tamoxifen failure

1990 • 147 citations

The directly repeated RG(G/T)TCA motifs of the rat and mouse cellular retinol-binding protein II genes are promiscuous binding sites for RAR, RXR, HNF-4, and ARP-1 homo- and heterodimers.

1994 • 142 citations

Oncogenic Neu/ErbB-2 Increases Ets, AP-1, and NF-kB-dependent Gene Expression, and Inhibiting Ets Activation Blocks Neu-mediated Cellular Transformation

1996 • 127 citations

Highly-expressed p100/p52 (NFKB2) sequesters other NF-kappa B-related proteins in the cytoplasm of human breast cancer cells.

1995 • 126 citations

Variant Estrogen Receptor mRNA Species Detected in Human Breast Cancer Biopsy Samples

1989 • 111 citations

Identification of a Naturally Occurring Transforming Variant of the p65 Subunit of NF-κB

1992 • 105 citations

Transcriptional repression of the neu protooncogene by estrogen stimulated estrogen receptor.

1992 • 100 citations

Inhibition of Estrogen Receptor Activity by the Tumor Promoter 12-O-Tetradeconylphorbol-13-Acetate: A Molecular Analysis

1991 • 94 citations

Progression of MCF-7 breast cancer cells to antiestrogen-resistant phenotype is accompanied by elevated levels of AP-1 DNA-binding activity.

1996 • 87 citations

Specific inhibition of RelB/p52 transcriptional activity by the C-terminal domain of p100.

1995 • 80 citations

Urokinase plasminogen activator as a prognostic marker in different subgroups of patients with breast cancer

1994 • 70 citations

Mechanisms of hormone resistance in breast cancer

1993 • 67 citations

Protein-tyrosine Kinase Activation Is Required for Lipopolysaccharide Induction of Interleukin 1β and NFκB Activation, but Not NFκB Nuclear Translocation

1996 • 66 citations

Activation of the serum response factor by p65/NF-kappaB.

1996 • 66 citations

Hormone resistance, invasiveness, and metastatic potential in breast cancer

1993 • 63 citations

Urokinase and urokinase receptor: a paracrinelautocrine system regulating cell migration and invasiveness

1993 • 56 citations

Prolonged treatment of breast cancer cells with antiestrogens increases the activating protein-1-mediated response: involvement of the estrogen receptor.

1995 • 54 citations

12-O-Tetradecanoyl-Phorbol-13-Acetate Induction of the Human Collagenase Gene Is Mediated By an Inducible Enhancer Element Located in the 5′-Flanking Region

1987 • 47 citations

Progression of hormone-dependent adenocarcinoma cells to hormone-independent spindle carcinoma cells in vitro in a clonal spontaneous rat mammary tumor cell line.

1995 • 19 citations

Genomic organization of the gene encoding the p65 subunit of NF-xB: multiple variants of the p65 protein may be generated by alternative splicing

1993 • 16 citations

A DNA motif present in alpha V integrin promoter exhibits dual binding preference to distinct transcription factors.

1995 • 14 citations

An alternatively spliced transcript, p65A2, of the gene encoding the p65 subunit of the transcription factor NF-κB

1994 • 12 citations

A novel NF-κB p65 spliced transcript lacking exons 6 and 7 in a non-small cell lung carcinoma cell line

1995 • 12 citations

Demonstration of a possible link between high grade malignancy in dimethylbenz[a]anthracene-induced rat mammary carcinoma and increased urokinase plasminogen activator content

1992 • 4 citations