Selective activation of NF-κB subunits in human breast cancer: potential roles for NF-κB2/p52 and for Bcl-3

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Cancer Cell Cycles

1996 • 5,379 citations

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1

1999 • 1,282 citations

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control

1997 • 875 citations

Constitutive Activation of NF-κB during Progression of Breast Cancer to Hormone-Independent Growth

1997 • 824 citations

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.

1997 • 780 citations

NF-κB Function in Growth Control: Regulation of Cyclin D1 Expression and G₀/G₁-to-S-Phase Transition

1999 • 777 citations

Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer.

1997 • 717 citations

Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras

1997 • 547 citations

The oncoprotein Bcl-3 directly transactivates through κB motifs via association with DNA-binding p50B homodimers

1993 • 506 citations

The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control

1990 • 469 citations

Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture

1998 • 433 citations

The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers.

1993 • 416 citations

A requirement for NF-kappa B activation in Bcr-Abl-mediated transformation

1998 • 397 citations

Nuclear Factor (NF)-κB2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell–mediated Immune Responses

1998 • 396 citations

Growth Factors in Breast Cancer

1995 • 378 citations

Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation

1997 • 375 citations

Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IκBα

1999 • 347 citations

The Bcl-3 oncoprotein acts as a bridging factor between NF-κB/Rel and nuclear co-regulators

1999 • 314 citations

Cellular Transformation and Malignancy Induced by ras Require c-jun

1996 • 283 citations

TGFβ1 Inhibits NF-κB/Rel Activity Inducing Apoptosis of B Cells: Transcriptional Activation of IκBα

1996 • 252 citations

NF-kappa B p105 is a target of Ikappa B kinases and controls signal induction of Bcl-3-p50 complexes

1999 • 204 citations

Critical Roles for the Bcl-3 Oncoprotein in T Cell–Mediated Immunity, Splenic Microarchitecture, and Germinal Center Reactions

1997 • 179 citations

Gastric Hyperplasia and Increased Proliferative Responses of Lymphocytes in Mice Lacking the COOH-terminal Ankyrin Domain of NF-κB2

1997 • 178 citations

Elevated insulin-like growth factor I receptor autophosphorylation and kinase activity in human breast cancer.

1998 • 169 citations

Immunological defects in mice with a targeted disruption in Bcl-3.

1997 • 164 citations

Mitogenic Signaling By Colony-Stimulating Factor 1 and ras Is Suppressed by the ets-2 DNA-Binding Domain and Restored by myc Overexpression

1992 • 147 citations

Oncogenic Neu/ErbB-2 Increases Ets, AP-1, and NF-kB-dependent Gene Expression, and Inhibiting Ets Activation Blocks Neu-mediated Cellular Transformation

1996 • 127 citations

The proto-oncogene bcl-3 encodes an I kappa B protein.

1992 • 116 citations

BCL3 rearrangements and t(14;19) in chronic lymphocytic leukemia and other B-cell malignancies: A molecular and cytogenetic study

1997 • 113 citations

Regulation of NFKB1 proteins by the candidate oncoprotein BCL-3: generation of NF-kappa B homodimers from the cytoplasmic pool of p50-p105 and nuclear translocation

1997 • 112 citations

Transcriptional Regulation of NF-κB2: Evidence for κB-Mediated Positive and Negative Autoregulation

1994 • 112 citations

BCL3 Encodes a Nuclear Protein Which Can Alter the Subcellular Location of NF-κB Proteins

1994 • 109 citations

Rearranged NFKB-2 Genes in Lymphoid Neoplasms Code for Constitutively Active Nuclear Transactivators

1995 • 80 citations

t(14;19)/BCL3 rearrangements in lymphoproliferative disorders: A review of 23 cases

1997 • 75 citations

Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice

1998 • 73 citations

Depletion of c-myc with specific antisense sequences reverses the transformed phenotype in ras oncogene-transformed NIH 3T3 cells.

1991 • 61 citations

Structural and functional analysis of NF-kappa B. Determinants of DNA binding specificity and protein interaction.

1994 • 41 citations

IκBα Overexpression Delays Tumor Formation in v-rel Transgenic Mice

1997 • 16 citations

Depletion of c-myc with Specific Antisense Sequences Reverses the Transformed Phenotype in ras Oncogene-Transformed NIH 3T3 Cells

1991 • 15 citations