The nuclear factor kappa B (NF-κB): A potential therapeutic target for estrogen receptor negative breast cancers

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Activators and Target Genes of Rel/NF-кB Transcription Factors

2003 • 3,164 citations

NF-κB: Ten Years After

1996 • 3,008 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976

1993 • 1,589 citations

The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

1998 • 1,561 citations

A Matter of Life and Cell Death

1998 • 1,523 citations

How NF-κB is activated: the role of the IκB kinase (IKK) complex

1999 • 1,133 citations

Aberrant rel/nfkb genes and activity in human cancer

1999 • 1,127 citations

Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation

1998 • 1,070 citations

Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB

1999 • 1,001 citations

Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene

1999 • 978 citations

IKK-γ is an essential regulatory subunit of the IκB kinase complex

1998 • 950 citations

Constitutive Activation of NF-κB during Progression of Breast Cancer to Hormone-Independent Growth

1997 • 824 citations

NF-κB Function in Growth Control: Regulation of Cyclin D1 Expression and G₀/G₁-to-S-Phase Transition

1999 • 777 citations

Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer.

1997 • 717 citations

Selective Inhibition of NF-κB Activation by a Peptide That Blocks the Interaction of NEMO with the IκB Kinase Complex

2000 • 685 citations

Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition.

2001 • 544 citations

IKK1-deficient mice exhibit abnormal development of skin and skeleton

1999 • 475 citations

Epidermal growth factor-induced nuclear factor κB activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells

2000 • 355 citations

A Novel Positive Feedback Loop Mediated by the Docking Protein Gab1 and Phosphatidylinositol 3-Kinase in Epidermal Growth Factor Receptor Signaling

2000 • 350 citations

IκB Kinase (IKK)-Associated Protein 1, a Common Component of the Heterogeneous IKK Complex

1999 • 333 citations

Isolation and characterization of a gene specifically expressed in different metastatic cells and whose deduced gene product has a high degree of homology to a Ca2+-binding protein family.

1989 • 302 citations

HTLV-I Tax Protein Binds to MEKK1 to Stimulate IκB Kinase Activity and NF-κB Activation

1998 • 260 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 1986. 46: 705-716.

2006 • 219 citations

Complete lack of NF-κB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation

2000 • 202 citations

?Studies on the estrogen receptor in breast cancer? ? 20 years as a target for the treatment and prevention of cancer

1995 • 155 citations

Growth Factor Synthesis and Human Breast Cancer Progression

1995 • 140 citations

Gö 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level-producing reservoir cells in vitro.

1993 • 138 citations

Oncogenic Neu/ErbB-2 Increases Ets, AP-1, and NF-kB-dependent Gene Expression, and Inhibiting Ets Activation Blocks Neu-mediated Cellular Transformation

1996 • 127 citations

Epidermal growth factor activation of NF-κB is mediated through IκBα degradation and intracellular free calcium

1998 • 123 citations

Effect ofmts1 (S100A4) expression on the progression of human breast cancer cells

1996 • 109 citations

Interaction and Functional Cooperation of NF-κB with Smads

2000 • 109 citations

NF-κB activation and interleukin 6 production in fibroblasts by estrogen receptor-negative breast cancer cell-derived interleukin 1α

1998 • 91 citations

The inhibitory effects of transforming growth factor beta1 on breast cancer cell proliferation are mediated through regulation of aberrant nuclear factor-kappaB/Rel expression.

1999 • 89 citations

Vascular endothelial growth factor effects on nuclear factor-kappaB activation in hematopoietic progenitor cells.

2001 • 55 citations

A New Interpretation of Antiestrogen Actiona

1995 • 52 citations

Calmodulin Is Essential for Estrogen Receptor Interaction with Its Motif and Activation of Responsive Promoter

1998 • 48 citations

Cooperative inhibition of NF-kappa B and Tat-induced superactivation of human immunodeficiency virus type 1 long terminal repeat.

1993 • 46 citations