Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

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1996 • 5,936 citations

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NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

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Tumor Cell Interactions with the Extracellular Matrix During Invasion and Metastasis

1993 • 1,523 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor

1988 • 1,200 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

Transcriptional regulation of the ovalbumin and conalbumin genes by steroid hormones in chick oviduct.

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Transcriptional regulation of hemoglobin switching in chicken embryos.

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1997 • 712 citations

The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells.

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1996 • 604 citations

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1992 • 476 citations

The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control

1990 • 469 citations

Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5'-regulatory region. Induction by cytokines and phorbol ester.

1991 • 419 citations

Autoregulation of I kappa B alpha activity.

1994 • 419 citations

B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-κB p50

1991 • 403 citations

NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress.

1994 • 361 citations

Phosphorylation of IκBα Precedes but Is Not Sufficient for Its Dissociation from NF-κB

1995 • 351 citations

Enhanced Tumorigenicity and Invasion-Metastasis by Hepatocyte Growth Factor/Scatter Factor-Met Signalling in Human Cells Concomitant with Induction of the Urokinase Proteolysis Network

1996 • 312 citations

Directed Plasminogen Activation at the Surface of Normal and Malignant Cells

1991 • 291 citations

Ablation of transplanted HTLV-I tax-transformed tumors in mice by antisense inhibition of NF-kappa B

1993 • 249 citations

An NFxB-like factor is essential but not sufficient for cytokine induction of endothelial leukocyte adhesion molecule 1 (ELAM-1) gene transcription

1991 • 245 citations

Pancreatic carcinoma

1997 • 224 citations

The Ets-1 and Ets-2 transcription factors activate the promoters for invasion-associated urokinase and collagenase genes in response to epidermal growth factor

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Epidermal growth factor rapidly stimulates prolactin gene transcription

1982 • 208 citations

Ablation of Transplanted HTLV-I Tax-Transformed Tumors in Mice by Antisense Inhibition of NF-κB

1992 • 207 citations

A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene.

1992 • 171 citations

Urokinase Plasminogen Activator and Gelatinases Are Associated with Membrane Vesicles Shed by Human HT1080 Fibrosarcoma Cells

1997 • 169 citations

Expression of HLA-A,B,C antigens on primary and metastatic tumor cell populations of human carcinomas.

1991 • 160 citations

Regulation of Urokinase-Type Plasminogen Activator Gene Transcription by Macrophage Colony-Stimulating Factor

1995 • 130 citations

KBF1 (p50 NF-kappa B homodimer) acts as a repressor of H-2Kb gene expression in metastatic tumor cells.

1993 • 127 citations

A regulatory element that mediates co-operation between a PEA3-AP-1 element and an AP-1 site is required for phorbol ester induction of urokinase enhancer activity in HepG2 hepatoma cells.

1992 • 126 citations

Expression of Human Recombinant Plasminogen Activators Enhances Invasion and Experimental Metastasis of H-ras-Transformed NIH 3T3 Cells

1989 • 120 citations

Collagen Zymography as a Sensitive and Specific Technique for the Determination of Subpicogram Levels of Interstitial Collagenase

1998 • 111 citations

Inhibitors of urokinase reduce size of prostate cancer xenografts in severe combined immunodeficient mice.

1997 • 102 citations

Expression of human recombinant plasminogen activators enhances invasion and experimental metastasis of H-ras-transformed NIH 3T3 cells.

1989 • 95 citations

Presence of urokinase in serum-free primary rat hepatocyte cultures and its role in activating hepatocyte growth factor.

1996 • 86 citations

Role of plasminogen activator and of 92-KDa type IV collagenase in glioblastoma invasion using anin vitro Matrigel model

1994 • 73 citations

Involvement of a Mitogen-activated Protein Kinase Signaling Pathway in the Regulation of Urokinase Promoter Activity by c-Ha-ras

1995 • 72 citations

Role of Mitogen-activated Protein Kinases and c-Jun/AP-1 trans-Activating Activity in the Regulation of Protease mRNAs and the Malignant Phenotype in NIH 3T3 Fibroblasts

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The α6-integrin receptor in pancreatic carcinoma

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Expression of the v-rel oncogene in reticuloendotheliosis virus-transformed fibroblasts

1988 • 50 citations

Plasminogen activator gene expression is induced by the src oncogene product and tumor promoters.

1990 • 47 citations

Related subunits of NF-κB map to two distinct loci associated with translocations in leukemia, NFKB1 and NFKB2

1992 • 43 citations

Molecular Biology and the Diagnosis and Treatment of Adenocarcinoma of the Pancreas

1996 • 37 citations

Secretion of plasminogen activators by human colorectal and gastric tumor explants

1988 • 33 citations

Identification of 3',5'-cyclic adenosine monophosphate-inducible nuclear factors binding to the human urokinase promoter in mouse Sertoli cells.

1993 • 30 citations

Differential modulation of plasminogen activator gene expression by oncogene-encoded protein tyrosine kinases.

1993 • 27 citations

Stimulation of urokinase expression by TNF-α requires the activation of binding sites for the AP-1 and PEA3 transcription factors

1995 • 27 citations

Urokinase‐type plasminogen activator biosynthesis is induced by the EJ‐Ha‐ras oncogene in CL26 mouse colon carcinoma cells

1989 • 24 citations

Activation of Oncogenicity of the c-rel Proto-Oncogene

1986 • 20 citations

Transformation of avian lymphoid cells by reticuloendotheliosis virus

1988 • 17 citations

Role of LFB3 in Cell-specific cAMP Induction of the Urokinase-type Plasminogen Activator Gene

1995 • 16 citations