RelB Cellular Regulation and Transcriptional Activity Are Regulated by p100

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 • 2,048 citations

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

1997 • 1,802 citations

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

2001 • 1,333 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region

1999 • 1,011 citations

NF-κB-Inducing Kinase Regulates the Processing of NF-κB2 p100

2001 • 807 citations

Leptomycin B Inhibition of Signal-Mediated Nuclear Export by Direct Binding to CRM1

1998 • 801 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention.

1992 • 731 citations

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination.

1995 • 558 citations

NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176

1998 • 533 citations

Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression.

1994 • 453 citations

Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase

1999 • 448 citations

The precursor of NF-κB p50 has IκB-like functions

1992 • 409 citations

RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B.

1992 • 375 citations

A nuclear export signal in the N-terminal regulatory domain of IκBα controls cytoplasmic localization of inactive NF-κB/IκBα complexes

2000 • 368 citations

IκB proteins: structure, function and regulation

1997 • 330 citations

p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction.

1993 • 291 citations

Sequential Induction of NF-κB/Rel Family Proteins during B-Cell Terminal Differentiation

1994 • 275 citations

An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of Ikappa Balpha

1999 • 264 citations

Distinct NF-κB/Rel transcription factors are responsible for tissue-specific and inducible gene activation

1993 • 225 citations

Molecular Cloning and Cell Cycle-dependent Expression of Mammalian CRM1, a Protein Involved in Nuclear Export of Proteins

1997 • 212 citations

NF-kappa B p105 is a target of Ikappa B kinases and controls signal induction of Bcl-3-p50 complexes

1999 • 204 citations

The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation

1998 • 198 citations

The NF-kappa B p50 precursor, p105, contains an internal I kappa B-like inhibitor that preferentially inhibits p50.

1992 • 178 citations

Differential expression of Rel/NF-κB and octamer factors is a hallmark of the generation and maturation of dendritic cells

2000 • 175 citations

I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity.

1992 • 167 citations

RelB regulation of chemokine expression modulates local inflammation.

1997 • 163 citations

Cytoplasmic Sequestration of Rel Proteins by IκBα Requires CRM1-Dependent Nuclear Export

2000 • 151 citations

Expression of relB transcripts during lymphoid organ development: specific expression in dendritic antigen-presenting cells

1993 • 149 citations

Nuclear Localization of IκBα Is Mediated by the Second Ankyrin Repeat: the IκBα Ankyrin Repeats Define a Novel Class of cis-Acting Nuclear Import Sequences

1998 • 142 citations

A Novel Nuclear Export Signal Sensitive to Oxidative Stress in the Fission Yeast Transcription Factor Pap1

1999 • 141 citations

Nuclear localization of RelB is associated with effective antigen-presenting cell function.

1997 • 137 citations

Constitutive and inducible Rel/NF-kappa B activities in mouse thymus and spleen.

1994 • 120 citations

The generation of nfkb2 p52: mechanism and efficiency

1999 • 114 citations

Regulation of NF-κB activity by IκB-related proteins in adenocarcinoma cells

1999 • 113 citations

NF-κB p100 (Lyt-10) is a Component of H2TF1 and can Function as an IκB-Like Molecule

1993 • 106 citations

Heterogeneous chromosomal aberrations generate 3' truncations of the NFKB2/lyt-10 gene in lymphoid malignancies

1994 • 105 citations

Differential Regulation of NF-κB2(p100) Processing and Control by Amino-Terminal Sequences

1996 • 96 citations

Two distinct mechanisms contribute to the constitutive activation of RelB in lymphoid cells.

1994 • 91 citations

Proteolytic Processing of NF- κB/I κB in Human Monocytes

1995 • 88 citations

Both N- and C-Terminal Domains of RelB Are Required for Full Transactivation: Role of the N-Terminal Leucine Zipper-Like Motif

1993 • 87 citations

Both multiorgan inflammation and myeloid hyperplasia in RelB-deficient mice are T cell dependent.

1996 • 83 citations

Specific inhibition of RelB/p52 transcriptional activity by the C-terminal domain of p100.

1995 • 80 citations

Rearrangement and altered expression of the NFKB-2 gene in human cutaneous T-lymphoma cells.

1994 • 80 citations

Differential Expression of the Transcription Factor NF-κB during Human Mononuclear Phagocyte Differentiation to Macrophages and Dendritic Cells

2000 • 80 citations

New insights into the roles of ReL/NF-κB transcription factors in immune function, hemopoiesis and human disease

1999 • 74 citations

Rearranged NFKB2 gene in the HUT78 T-lymphoma cell line codes for a constitutively nuclear factor lacking transcriptional repressor functions.

1994 • 68 citations

NF-kappa B precursor p100 inhibits nuclear translocation and DNA binding of NF-kappa B/rel-factors.

1993 • 68 citations

The Ability of CD40L, but Not Lipopolysaccharide, To Initiate Immunoglobulin Switching to Immunoglobulin G1 Is Explained by Differential Induction of NF-κB/Rel Proteins

1998 • 67 citations

Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor.

1994 • 64 citations

CD40, but not lipopolysaccharide and anti-IgM stimulation of primary B lymphocytes, leads to a persistent nuclear accumulation of RelB.

1996 • 47 citations

Characterization of Elements Determining the Dimerization Properties of RelB and p50

1995 • 38 citations

Human RelB (I-Rel) functions as a kappa B site-dependent transactivating member of the family of Rel-related proteins.

1994 • 38 citations

Receptor-specific induction of NF-kappaB components in primary B cells

1998 • 38 citations

The Involvement of the Candidate Proto-Oncogene NFKB2/lyt-10 in Lymphoid Malignancies

1996 • 36 citations

Induction of nuclear factor-kappa B during primary B cell differentiation.

1998 • 35 citations

Regulation of major histocompatibility complex class I expression by NF-κB-related proteins in breast cancer cells

1998 • 33 citations

Induction of Nuclear Factor-κB During Primary B Cell Differentiation

1998 • 31 citations

Identification of Signal-induced IκB-α Kinases in Human Endothelial Cells

1996 • 25 citations

Inducible Activation of RelB in Fibroblasts

1996 • 22 citations