Epitope-specific enhancement of antigen presentation by invariant chain.

Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic

1991 • 832 citations

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

1991 • 663 citations

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1990 • 565 citations

Intracellular transport of class II MHC molecules directed by invariant chain

1990 • 548 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

Differential requirements for antigen processing by macrophages for lysozyme-specific T cell hybridomas.

1984 • 272 citations

Liposome-encapsulated antigens are processed in lysosomes, recycled, and presented to T cells

1991 • 250 citations

Reduction of disulfide bonds within lysosomes is a key step in antigen processing.

1991 • 245 citations

Mechanisms influencing the immunodominance of T cell determinants.

1988 • 227 citations

Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules.

1992 • 197 citations

A role of la-associated invariant chains in antigen processing and pressentation

1989 • 184 citations

Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus.

1991 • 146 citations

Effects of pH and polysaccharides on peptide binding to class II major histocompatibility complex molecules.

1991 • 144 citations

Invariant chain influences the immunological recognition of MHC class II molecules

1990 • 127 citations

Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41

1992 • 124 citations

Chloroquine affects biosynthesis of Ia molecules by inhibiting dissociation of invariant (gamma) chains from alpha-beta dimers in B cells.

1985 • 123 citations

Effect of pH on MHC class II-peptide interactions.

1992 • 101 citations

Invariant chain promotes egress of poorly expressed, haplotype-mismatched class II major histocompatibility complex A alpha A beta dimers from the endoplasmic reticulum/cis-Golgi compartment.

1991 • 94 citations

The morphology but not the function of endosomes and lysosomes is altered by brefeldin A.

1992 • 77 citations

Antigen presentation of hen egg‐white lysozyme but not of ribonuclease A is augmented by the major histocompatibility complex class II‐associated invariant chain

1991 • 74 citations

MHC class II-restricted presentation of native protein antigen by B cells is inhibitable by cycloheximide and brefeldin A.

1990 • 61 citations

Exogenous peptides compete for the presentation of endogenous antigens to major histocompatibility complex class II-restricted T cells.

1991 • 60 citations

T cell recognition of bovine ribonuclease. Self/non-self discrimination at the level of binding to the I-Ak molecule.

1988 • 47 citations

Selective immunosuppression by administration of major histocompatibility complex (MHC) class II-binding peptides. I. Evidence for in vivo MHC blockade preventing T cell activation.

1992 • 43 citations

Correlation between invariant chain expression level and capability to present antigen to MHC class II-restricted T cells

1991 • 33 citations