Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II.

THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY

1963 • 10,322 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.

1993 • 900 citations

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1992 • 763 citations

Peptides Presented to the Immune System by the Murine Class II Major Histocompatibility Complex Molecule I-A _d

1992 • 654 citations

Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules

1993 • 630 citations

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1990 • 565 citations

Intracellular transport of class II MHC molecules directed by invariant chain

1990 • 548 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides

1992 • 380 citations

An essential role for HLA–DM in antigen presentation by class II major histocompatibility molecules

1994 • 378 citations

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.

1993 • 326 citations

Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways

1990 • 303 citations

HLA-DMA and DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells

1994 • 247 citations

The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44

1993 • 245 citations

Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes

1990 • 236 citations

Purification and characterization of class II histocompatibility antigens from a homozygous human B cell line.

1987 • 222 citations

Invariant Chain Peptides in Most HLA-DR Molecules of an Antigen-Processing Mutant

1992 • 218 citations

The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tail.

1993 • 206 citations

Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules.

1992 • 197 citations

Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients.

1993 • 196 citations

The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules.

1994 • 196 citations

Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment.

1994 • 188 citations

The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy.

1994 • 184 citations

Comparison of peptides bound to spleen and thymus class II.

1993 • 168 citations

Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41

1992 • 124 citations

The segment of invariant chain that is critical for association with major histocompatibility complex class II molecules contains the sequence of a peptide eluted from class II polypeptides.

1993 • 123 citations

Mapping functional regions in the lumenal domain of the class II-associated invariant chain.

1994 • 122 citations

Diversity of Endogenous Epitopes Bound to MHC Class II Molecules Limited by Invariant Chain

1994 • 116 citations

Structural analysis of peptides capable of binding to more than one Ia antigen.

1989 • 112 citations

Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain.

1994 • 104 citations

Effect of pH on MHC class II-peptide interactions.

1992 • 101 citations

Stable surface expression of invariant chain prevents peptide presentation by HLA-DR.

1992 • 94 citations

Invariant chain promotes egress of poorly expressed, haplotype-mismatched class II major histocompatibility complex A alpha A beta dimers from the endoplasmic reticulum/cis-Golgi compartment.

1991 • 94 citations

A mutant human histocompatibility leukocyte antigen DR molecule associated with invariant chain peptides.

1994 • 91 citations

Assembly of HLA DR1 molecules translated in vitro: binding of peptide in the endoplasmic reticulum precludes association with invariant chain.

1994 • 87 citations

MHC class II antigen processing: biology of invariant chain

1994 • 83 citations

Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines.

1994 • 77 citations

The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tail

1993 • 58 citations

Putting together an MHC class I molecule

1993 • 53 citations

Selective release of some invariant chain-derived peptides from HLA-DR1 molecules at endosomal pH.

1994 • 48 citations

A disease-related epitope of Torpedo acetylcholine receptor. Residues involved in I-Ab binding, self-nonself discrimination, and TCR antagonism.

1994 • 47 citations

Invariant chain prevents the HLA-DR-restricted presentation of a cytosolic peptide.

1994 • 46 citations

High affinity for class II molecules as a necessary but not sufficient characteristic of encephalitogenic determinants

1992 • 39 citations

Enhanced antigen presentation in the absence of the invariant chain endosomal localization signal.

1993 • 38 citations

Invariant chain influences post-translational processing of HLA-DR molecules.

1991 • 35 citations

HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells

1994 • 11 citations

An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules

1994 • 1 citations