Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain.

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

A Method for Determining the Sedimentation Behavior of Enzymes: Application to Protein Mixtures

1961 • 5,561 citations

Protein folding in the cell

1992 • 4,138 citations

High resolution two-dimensional electrophoresis of basic as well as acidic proteins

1977 • 3,556 citations

SV40-transformed simian cells support the replication of early SV40 mutants

1981 • 2,564 citations

Brownian motion in biological membranes.

1975 • 1,723 citations

Properties of Monoclonal Antibodies to Mouse Ig Allotypes, H-2, and Ia Antigens

1979 • 993 citations

Protein Oligomerization in the Endoplasmic Reticulum

1989 • 993 citations

BIOSYNTHETIC PROTEIN TRANSPORT AND SORTING BY THE ENDOPLASMIC RETICULUM AND GOLGI

1987 • 985 citations

Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas.

1986 • 896 citations

Polypeptide chain binding proteins: Catalysts of protein folding and related processes in cells

1989 • 884 citations

Immunoglobulin heavy chain binding protein

1983 • 849 citations

Control of Protein Exit from the Endoplasmic Reticulum

1989 • 794 citations

An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2

1987 • 699 citations

The class II molecules of the human and murine major histocompatibility complex

1984 • 664 citations

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

1991 • 663 citations

Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens

1978 • 589 citations

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1990 • 565 citations

Intracellular transport of class II MHC molecules directed by invariant chain

1990 • 548 citations

Major histocompatibility antigens: The human (HLA-A,-B,-C) and murine (H-2K, H-2D) class I molecules

1981 • 511 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route

1990 • 445 citations

Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast.

1990 • 435 citations

Regulation of Protein Export From the Endoplasmic Reticulum

1988 • 421 citations

Antibodies to the Golgi complex and the rough endoplasmic reticulum.

1982 • 418 citations

MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

1991 • 394 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

The human transferrin receptor gene: genomic organization, and the complete primary structure of the receptor deduced from a cDNA sequence

1984 • 337 citations

Role for intracellular proteases in the processing and transport of class II HLA antigens.

1988 • 336 citations

Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain

1991 • 326 citations

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.

1993 • 326 citations

Folding of influenza hemagglutinin in the endoplasmic reticulum.

1991 • 318 citations

Participation of a novel 88-kD protein in the biogenesis of murine class I histocompatibility molecules.

1991 • 312 citations

Interactions of misfolded influenza virus hemagglutinin with binding protein (BiP).

1989 • 312 citations

Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigens

1982 • 308 citations

The human class II MHC protein HLA-DR1 assembles as empty αβ heterodimers in the absence of antigenic peptide

1992 • 306 citations

Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways

1990 • 303 citations

Endoplasmic reticulum resident protein of 90 kilodaltons associates with the T- and B-cell antigen receptors and major histocompatibility complex antigens during their assembly.

1992 • 259 citations

The endoplasmic reticulum stress protein GRP94, in addition to BiP, associates with unassembled immunoglobulin chains.

1992 • 243 citations

Pre-Golgi degradation of newly synthesized T-cell antigen receptor chains: intrinsic sensitivity and the role of subunit assembly.

1989 • 228 citations

Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain.

1986 • 226 citations

Lateral diffusion in an archipelago. The effect of mobile obstacles

1987 • 218 citations

Detection of a common polypeptide chain in I-A and I-E sub-region immunoprecipitates

1979 • 217 citations

Role of potentially charged transmembrane residues in targeting proteins for retention and degradation within the endoplasmic reticulum.

1991 • 215 citations

Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP.

1991 • 210 citations

Differential effects of mutations in three domains on folding, quaternary structure, and intracellular transport of vesicular stomatitis virus G protein.

1988 • 210 citations

Cooperative interaction of B lymphocytes with antigen-specific helper T lymphocytes is MHC restricted

1981 • 207 citations

Interaction with newly synthesized and retained proteins in the endoplasmic reticulum suggests a chaperone function for human integral membrane protein IP90 (calnexin)

1993 • 203 citations

Matrix control of protein diffusion in biological membranes.

1981 • 202 citations

Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules.

1992 • 197 citations

Role of Transmembrane Domain Interactions in the Assembly of Class II MHC Molecules

1992 • 191 citations

Assembly and transport properties of invariant chain trimers and HLA-DR-invariant chain complexes.

1992 • 189 citations

Misfolding and aggregation of newly synthesized proteins in the endoplasmic reticulum.

1992 • 177 citations

Vesicular stomatitis virus G proteins with altered glycosylation sites display temperature-sensitive intracellular transport and are subject to aberrant intermolecular disulfide bonding.

1988 • 170 citations

Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes surface expression of occupied molecules

1993 • 157 citations

Biosynthesis and glycosylation of the invariant chain associated with HLA-DR antigens.

1982 • 155 citations

Quality control in the endoplasmic reticulum: folding and misfolding of vesicular stomatitis virus G protein in cells and in vitro.

1990 • 153 citations

Reduction of Endogenous GRP78 Levels Improves Secretion of a Heterologous Protein in CHO Cells

1988 • 152 citations

Invariant chain trimers are sequestered in the rough endoplasmic reticulum in the absence of association with HLA class II antigens.

1990 • 149 citations

HLA-DR associates with specific stress proteins and is retained in the endoplasmic reticulum in invariant chain negative cells.

1992 • 148 citations

Molecular Crowding on the Cell Surface

1988 • 146 citations

Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus.

1991 • 146 citations

Relationship between invariant chain expression and major histocompatibility complex class II transport into early and late endocytic compartments.

1993 • 146 citations

A role for calnexin (IP90) in the assembly of class II MHC molecules.

1994 • 144 citations

Cell surface expression of class II histocompatibility antigens occurs in the absence of the invariant chain.

1986 • 142 citations

Selective degradation of T cell antigen receptor chains retained in a pre-Golgi compartment.

1988 • 139 citations

Posttranslational folding of vesicular stomatitis virus G protein in the ER: involvement of noncovalent and covalent complexes.

1993 • 113 citations

BIP associates with newly synthesized subunits of the mouse muscle nicotinic receptor.

1991 • 108 citations

Sequence analysis and structure-function correlations of murine q, k, u, s, and f haplotype I-A beta cDNA clones.

1986 • 105 citations

Binding protein BiP is required for translocation of secretory proteins into the endoplasmic reticulum in Saccharomyces cerevisiae.

1991 • 102 citations

Distinct epitopes on I^k gene products identified by monoclonal antibodies

1980 • 101 citations

Intracellular transport of soluble and membrane-bound glycoproteins: folding, assembly and secretion of anchor-free influenza hemagglutinin.

1990 • 97 citations

Stable surface expression of invariant chain prevents peptide presentation by HLA-DR.

1992 • 94 citations

Invariant chain promotes egress of poorly expressed, haplotype-mismatched class II major histocompatibility complex A alpha A beta dimers from the endoplasmic reticulum/cis-Golgi compartment.

1991 • 94 citations

The murine Ia alpha chains, E alpha and A alpha, show a surprising degree of sequence homology.

1983 • 90 citations

Oligosaccharide microheterogeneity of the murine major histocompatibility antigens. Reproducible site-specific patterns of sialylation and branching in asparagine-linked oligosaccharides.

1985 • 87 citations

BiP forms stable complexes with unassembled subunits of the acetylcholine receptor in transfected COS cells and in C2 muscle cells

1992 • 58 citations

Interaction between I region loci influences the expression of a cell surface Ia antigen.

1980 • 55 citations

Defective intracellular transport as a common mechanism limiting expression of inappropriately paired class II major histocompatibility complex alpha/beta chains.

1991 • 52 citations

Characterization of fragments of the murine Ia-associated invariant chain.

1991 • 49 citations

Time Course of Intracellular Associations, Processing, and Cleavages of Ii Forms and Class II Major Histocompatibility Complex Molecules

1989 • 39 citations