Anatomy of the antibody molecule

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

1983 • 14,802 citations

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

Sequences of proteins of immunological interest

1984 • 3,427 citations

Catalysis in chemistry and enzymology

1969 • 3,236 citations

Analytical molecular surface calculation

1983 • 2,454 citations

Hydrogen bonding in biological structures

1992 • 2,400 citations

Humanization of an anti-p185HER2 antibody for human cancer therapy.

1992 • 1,867 citations

Reshaping human antibodies for therapy

1988 • 1,555 citations

Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli.

1988 • 1,536 citations

Single-Chain Antigen-Binding Proteins

1988 • 1,450 citations

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.

1981 • 1,432 citations

Canonical structures for the hypervariable regions of immunoglobulins

1987 • 1,357 citations

Replacing the complementarity-determining regions in a human antibody with those from a mouse

1986 • 1,356 citations

AN ANALYSIS OF THE SEQUENCES OF THE VARIABLE REGIONS OF BENCE JONES PROTEINS AND MYELOMA LIGHT CHAINS AND THEIR IMPLICATIONS FOR ANTIBODY COMPLEMENTARITY

1970 • 1,308 citations

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-.ANG. resolution

1981 • 1,286 citations

Three-Dimensional Structure of an Antigen-Antibody Complex at 2.8 Å Resolution

1986 • 1,173 citations

Conformations of immunoglobulin hypervariable regions

1989 • 1,165 citations

Hydrogen bonding and biological specificity analysed by protein engineering

1985 • 1,050 citations

Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains.

1984 • 1,002 citations

The Antigenic Structure of Proteins: A Reappraisal

1984 • 957 citations

THE COVALENT STRUCTURE OF AN ENTIRE γG IMMUNOGLOBULIN MOLECULE

1969 • 869 citations

ANTIBODY-ANTIGEN COMPLEXES

1990 • 853 citations

The structure of protein-protein recognition sites.

1990 • 825 citations

Protein Data Bank

1984 • 731 citations

Three-Dimensional Structure of Immunoglobulins

1979 • 692 citations

Aromatic rings act as hydrogen bond acceptors

1988 • 685 citations

A humanized antibody that binds to the interleukin 2 receptor.

1989 • 624 citations

Three-dimensional structure of an antibody-antigen complex.

1987 • 615 citations

Phosphocholine binding immunoglobulin Fab McPC603

1986 • 576 citations

Three-dimensional structure of a complex of antibody with influenza virus neuraminidase

1987 • 556 citations

The binding site for C1q on IgG

1988 • 556 citations

Structural Evidence for Induced Fit as a Mechanism for Antibody-Antigen Recognition

1992 • 519 citations

Antibody framework residues affecting the conformation of the hypervariable loops

1992 • 507 citations

The Three-Dimensional Structure of a Phosphorylcholine-Binding Mouse Immunoglobulin Fab and the Nature of the Antigen Binding Site

1974 • 465 citations

Structure of an antibody-antigen complex: crystal structure of the HyHEL-10 Fab-lysozyme complex.

1989 • 456 citations

Crystallographic refinement and atomic models of the intact immunoglobulin molecule Kol and its antigen-binding fragment at 3.0 Å and 1.9 Å resolution

1980 • 455 citations

Immunoglobulin G: Functional sites

1985 • 442 citations

Structure, function and properties of antibody binding sites

1991 • 426 citations

A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin

1989 • 420 citations

Structural repertoire of the human VH segments

1992 • 396 citations

Domain association in immunoglobulin molecules

1985 • 389 citations

Three-Dimensional Structure of the Fab′ Fragment of a Human Immunoglobulin at 2.8-Å Resolution

1973 • 381 citations

Monoclonal Antibodies in Diagnosis and Therapy

1991 • 378 citations

Three-dimensional structure of an intact human immunoglobulin.

1977 • 373 citations

Structural Basis of Antibody Function

1983 • 371 citations

On the attribution of binding energy in antigen-antibody complexes McPC 603, D1.3, and HyHEL-5

1989 • 367 citations

Structure of a λ-type Bence-Jones protein at 3.5-Å resolution

1973 • 356 citations

Crystal Structures of an Antibody to a Peptide and Its Complex with Peptide Antigen at 2.8 Å

1990 • 352 citations

Reshaping Human Antibodies: Grafting an Antilysozyme Activity

1988 • 348 citations

Localization of the binding site for the human high-affinity Fc receptor on IgG

1988 • 287 citations

Length distribution of CDRH3 in antibodies

1993 • 277 citations

Molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI refined at 2.0-Å resolution

1975 • 266 citations

Recognition of a Cell-Surface Oligosaccharide of Pathogenic Salmonella by an Antibody Fab Fragment

1991 • 261 citations

Monoreactive high affinity and polyreactive low affinity rheumatoid factors are produced by CD5+ B cells from patients with rheumatoid arthritis.

1988 • 257 citations

An autoantibody to single‐stranded DNA: Comparison of the three‐dimensional structures of the unliganded fab and a deoxynucleotide–fab complex

1991 • 256 citations

Three-Dimensional Structure of Antibodies

1988 • 256 citations

The Three-Dimensional Structure at 6 A Resolution of a Human γG1 Immunoglobulin Molecule

1971 • 249 citations

Small rearrangements in structures of Fv and Fab fragments of antibody D 1.3 on antigen binding

1990 • 247 citations

Framework residue 71 is a major determinant of the position and conformation of the second hypervariable region in the VH domains of immunoglobulins

1990 • 238 citations

On the nature of antibody combining sites: Unusual structural features that may confer on these sites an enhanced capacity for binding ligands

1990 • 233 citations

Crystal and Molecular Structure of a Dimer Composed of the Variable Portions of the Bence-Jones Protein REI

1974 • 231 citations

Three‐dimensional structure of a fluorescein–Fab complex crystallized in 2‐methyl‐2,4‐pentanediol

1989 • 229 citations

The Three Dimensional Structure of a Combining Region-Ligand Complex of Immunoglobulin NEW at 3.5-Å Resolution

1974 • 227 citations

Three-dimensional structure of an idiotope–anti-idiotope complex

1990 • 227 citations

Three-Dimensional Structure of Immunoglobulins

1975 • 218 citations

The three-dimensional structure of an intact monoclonal antibody for canine lymphoma

1992 • 214 citations

The Three-Dimensional Structure of the Fab′ Fragment of a Human Myeloma Immunoglobulin at 2.0-Å Resolution

1974 • 213 citations

High resolution functional analysis of antibody-antigen interactions

1992 • 213 citations

Structure of Antibody-Antigen Complexes: Implications for Immune Recognition

1988 • 207 citations

Structure and function of the constant regions of immunoglobulins

1976 • 206 citations

Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex

1992 • 201 citations

Unusual distributions of amino acids in complementarity-determining (hypervariable) segments of heavy and light chains of immunoglobulins and their possible roles in specificity of antibody-combining sites.

1977 • 196 citations

The disulfide bonds in antibody variable domains: effects on stability, folding in vitro, and functional expression in Escherichia coli

1992 • 190 citations

Antibody-antigen complexes.

1988 • 189 citations

Structure of HIV-1 reverse transcriptase/DNA complex at 7 Å resolution showing active site locations

1992 • 186 citations

X-ray Structures of the Antigen-binding Domains from Three Variants of Humanized anti-p185HER2 Antibody 4D5 and Comparison with Molecular Modeling

1993 • 185 citations

Crystal structure of a streptococcal protein G domain bound to an Fab fragment

1992 • 180 citations

Immunoglobulin VH clan and family identity predicts variable domain structure and may influence antigen binding.

1992 • 178 citations

The three-dimensional structure of the carbohydrate within the Fc fragment of immunoglobulin G.

1983 • 178 citations

Crystallographic refinement of the three-dimensional structure of the FabD1.3-lysozyme complex at 2.5-A resolution

1991 • 175 citations

The galactan‐binding immunoglobulin Fab J539: An x‐ray diffraction study at 2.6‐Å resolution

1986 • 175 citations

Solution structure of human and mouse immunoglobulin M by synchrotron X-ray scattering and molecular graphics modelling

1991 • 172 citations

A possible procedure for reducing the immunogenicity of antibody variable domains while preserving their ligand-binding properties

1991 • 168 citations

Binding of 2,4-dinitrophenyl compounds and other small molecules to a crystalline .lambda.-type Bence-Jones dimer

1974 • 164 citations

Three-Dimensional Structure of an Angiotensin II-Fab Complex at 3 Å: Hormone Recognition by an Anti-Idiotypic Antibody

1992 • 162 citations

Reshaping a Human Monoclonal Antibody to Inhibit Human Respiratory Syncytial Virus Infection in Vivo

1991 • 162 citations

THE STRUCTURAL BASIS OF ANTIGEN-ANTIBODY RECOGNITION

1987 • 159 citations

The three-dimensional structure of the carbohydrate within the Fc fragment of immunoglobulin G

1983 • 150 citations

Two murine natural polyreactive autoantibodies are encoded by nonmutated germ-line genes.

1989 • 149 citations

Elbow motion in the immunoglobulins involves a molecular ball-and-socket joint

1988 • 149 citations

Three-dimensional structure determination of an anti-2-phenyloxazolone antibody: the role of somatic mutation and heavy/light chain pairing in the maturation of an immune response.

1990 • 145 citations

Radioimmunolocalization of human carcinoma xenografts with B72.3 second generation monoclonal antibodies.

1988 • 140 citations

Molecular anatomy of the antibody binding site.

1983 • 126 citations

Structural basis for the specificity of phosphorylcholine-binding immunoglobulins

1976 • 125 citations

Antibody: the flexible adaptor molecule

1990 • 125 citations

The Interplay Between Chemistry and Biology in the Design of Enzymatic Catalysts

1988 • 120 citations

Structure of a novel bence-jones protein (Rhe) fragment at 1·6 Å resolution

1983 • 117 citations

Structure at 4.5 Å; Resolution of a Phosphorylcholine-binding Fab

1973 • 113 citations

Humanized antibodies for therapy

1991 • 110 citations

Modelling of the combining sites of three anti-lysozyme monoclonal antibodies and of the complex between one of the antibodies and its epitope.

1986 • 110 citations

Variable region genes for the immunoglobulin framework are assembled from small segments of DNA—A hypothesis

1978 • 107 citations

A Conformation of Cyclosporin A in Aqueous Environment Revealed by the X-Ray Structure of a Cyclosporin-Fab Complex

1992 • 107 citations

Antibody structure

1993 • 102 citations

2·9Åresolution structure of an anti-dinitrophenyl-spin-label monoclonal antibody Fab fragment with bound hapten

1991 • 101 citations

Electrostatic fields in antibodies and antibody/antigen complexes

1992 • 99 citations

Structural basis for the specificity of antibody–antigen reactions and structural mechanisms for the diversification of antigen-binding specificities

1977 • 94 citations

CATALYTIC ANTIBODIES

1992 • 92 citations

Resolution d'un structure cristalline lorsque les positions d'une partie des atoms sont connues: traitement statistique

1953 • 87 citations

Three-dimensional structures of influenza virus neuraminidase-antibody complexes

1989 • 83 citations

Crystallization and structure determination of an autoimmune anti-poly(dT) immunoglobulin Fab fragment at 3.0 A resolution.

1987 • 82 citations

Genetically Engineered Antibody Molecules

1989 • 81 citations

Conformations of IgE bound to its receptor Fc.epsilon.RI and in solution

1991 • 80 citations

Three-dimensional structure of murine anti-p-azophenylarsonate Fab 36-71. 1. X-ray crystallography, site-directed mutagenesis, and modeling of the complex with hapten

1991 • 80 citations

Structural invariants of antigen binding: comparison of immunoglobulin VL-VH and VL-VL domain dimers.

1985 • 79 citations

Three-dimensional structure of an Fv from a human IgM immunoglobulin

1992 • 76 citations

Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface

1992 • 74 citations

Fc receptors and the action of antibodies

1991 • 72 citations

On the specificity of antibody/antigen interactions: Phosphocholine binding to McPC603 and the correlation of three-dimensional structure and sequence data

1985 • 67 citations

Computer models of the human immunoglobulins shape and segmental flexibility

1986 • 62 citations

Dynamic conformations compared for IgE and IgG1 in solution and bound to receptors

1992 • 62 citations

Structure of a human monoclonal antibody Fab fragment against gp41 of human immunodeficiency virus type 1.

1992 • 61 citations

Crystal Structures of Neuraminidase-Antibody Complexes

1989 • 61 citations

Crystal structure of human immunoglobulin fragment Fab new refined at 2.0 Å esolution

1992 • 60 citations

Refined crystal structure of a recombinant immunoglobulin domain and a complementarity-determining region 1-grafted mutant

1992 • 59 citations

Three-dimensional structure of a light chain dimer crystallized in water

1989 • 59 citations

The binding of opioid peptides to the Mcg light chain dimer: Flexible keys and adjustable locks

1987 • 57 citations

Three-dimensional structure of the Mcg IgG1 immunoglobulin☆

1983 • 56 citations

The structure determination of the variable portion of the Bence-Jones protein Au

1975 • 56 citations

Variability of three-dimensional structure in immunoglobulins.

1975 • 56 citations

Novel arrangement of immunoglobulin variable domains: x-ray crystallographic analysis of the .lambda.-chain dimer Bence-Jones protein Loc

1985 • 54 citations

Probing antibody diversity by 2D NMR: comparison of amino acid sequences, predicted structures, and observed antibody-antigen interactions in complexes of two antipeptide antibodies

1989 • 53 citations

Three‐dimensional structure of the Fab fragment of a neutralizing antibody to human rhinovirus serotype 2

1992 • 51 citations

Crystal structure of a chimeric Fab′ fragment of an antibody binding tumour cells

1992 • 45 citations

Structural implications of sequence variability in immunoglobulins.

1977 • 44 citations

Immunoglobulin Structures at High Resolution

1975 • 40 citations

Solution of a Fab (26-10)/digoxin complex by generalized molecular replacement

1991 • 39 citations

A model of the Fc of immunoglobulin E

1986 • 38 citations

Studies on the three-dimensional structure of immunoglobulins

1978 • 38 citations

Use of deuterium labelling in NMR studies of antibody combining site structure

1990 • 37 citations

Structure determination of a monoclonal Fab fragment specific for histidine-containing protein of the phosphoenolpyruvate: sugar phosphotransferase system of Escherichia coli.

1988 • 36 citations

Crystal and molecular structure of the dimer of variable domains of the Bence-Jones protein ROY

1977 • 36 citations

Catalytic Antibodies

1988 • 35 citations

The nature and importance of the inter‐ε chain disulfide bonds in human IgE

1991 • 32 citations

Antibody Fab assembly: The interface residues between CH1 and CL

1986 • 32 citations

Antibody–antigen flexibility

1987 • 31 citations

Twisting into shape

1992 • 31 citations

Structural Aspects of Antibodies and Antibody‐Antigen Complexes

2007 • 31 citations

Protein-protein recognition and the association of immunoglobulin constant domains

1990 • 29 citations

Crystallographic analysis of the interaction between cyclosporin A and the Fab fragment of a monoclonal antibody

1993 • 28 citations

Three-dimensional structure of two crystal forms of FabR19.9 from a monoclonal anti-arsonate antibody.

1992 • 27 citations

Structural Basis for Antigen-Antibody Recognition

1986 • 27 citations

Structure of a second crystal form of Bence-Jones protein Loc: strikingly different domain associations in two crystal forms of a single protein

1989 • 27 citations

The use of monoclonal antibodies for treatment of autoimmune disease

1990 • 27 citations

The three-dimensional structure of a human IgGl immunoglobulin at 4 Å resolution: a computer fit of various structural domains on the electron density map

1982 • 26 citations

Structural basis for the association of heavy and light chains and the relation of subgroups to the conformation of the active site of immunoglobulins

1975 • 24 citations

Structural and kinetic studies of the Fab fragment of a monoclonal anti-spin label antibody by nuclear magnetic resonance

1991 • 23 citations

A strong propensity toward loop formation characterizes the expressed reading frames of the D segments at the Ig H and T cell receptor loci

1991 • 23 citations

Analysis of immunoglobulin domain interactions

1988 • 21 citations

Conformational Flexibility in Immunoglobulins

1978 • 21 citations

Properties of polyreactive natural antibodies to self and foreign antigens

1990 • 20 citations

Localized Deletion-Insertion Mutations: A Major Factor in the Evolution of Immunoglobulin Structural Variability

1976 • 20 citations

Poly(Glu⁶⁰Ala³⁰Tyr¹⁰) (GAT)‐induced IgG monoclonal antibodies cross‐react with various self and non‐self antigens through the complementarity determining regions. Comparison with IgM monoclonal polyreactive natural antibodies

1990 • 18 citations

Antibody engineering

1989 • 17 citations

New concepts in monoclonal antibody based radioimmunodiagnosis and radioimmunotherapy of carcinoma

1991 • 16 citations

Immunoglobulin disulfide bridges: Theme and variations

1985 • 16 citations

Crystallization, preliminary X‐ray diffraction study, and crystal packing of a complex between anti‐Hen lysozyme antibody F9.13.7 and Guinea‐fowl lysozyme

1993 • 13 citations

Unexpected similarities in the crystal structures of the Mcg light-chain dimer and its hybrid with the weir protein

1985 • 12 citations

Crystal structure of an anti-Lewis a Fab determined by molecular replacement methods

1987 • 11 citations

Structure and specificity of antibody molecules

1975 • 11 citations

Molecular-replacement structure of guinea pig IgGl pFc' refined at 3.1Å resolution

1985 • 10 citations

Characterization and preliminary crystallographic data on the VL-related fragment of the human κI Bence Jones protein Wat

1981 • 9 citations

Crystal parameters and molecular replacement of an anticholera toxin peptide complex

1991 • 7 citations

Use of molecular replacement in the solution of an immunoglobulin Fab fragment structure

1991 • 3 citations