Immunoglobulin VH clan and family identity predicts variable domain structure and may influence antigen binding.

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

Sequences of proteins of immunological interest

1984 • 3,427 citations

Conformations of immunoglobulin hypervariable regions

1989 • 1,165 citations

Comparison of super-secondary structures in proteins

1973 • 885 citations

The role of clonal selection and somatic mutation in autoimmunity

1987 • 714 citations

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

1984 • 644 citations

Three-dimensional structure of an antibody-antigen complex.

1987 • 615 citations

Phosphocholine binding immunoglobulin Fab McPC603

1986 • 576 citations

Early Restriction of the Human Antibody Repertoire

1987 • 546 citations

Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions

1990 • 485 citations

Structure of an antibody-antigen complex: crystal structure of the HyHEL-10 Fab-lysozyme complex.

1989 • 456 citations

Crystallographic refinement and atomic models of the intact immunoglobulin molecule Kol and its antigen-binding fragment at 3.0 Å and 1.9 Å resolution

1980 • 455 citations

Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences.

1990 • 414 citations

The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain.

1990 • 352 citations

Developmentally Controlled Expression of Immunoglobulin V _H Genes

1985 • 349 citations

Preliminary refinement and structural analysis of the Fab fragment from human immunoglobulin new at 2.0 A resolution.

1978 • 293 citations

Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life.

1990 • 252 citations

Relationship of human variable region heavy chain germ-line genes to genes encoding anti-DNA autoantibodies.

1987 • 251 citations

Identification of the region of T cell receptor β chain that interacts with the self-superantigen MIs-1a

1990 • 242 citations

Organization and evolution of variable region genes of the human immunoglobulin heavy chain

1986 • 227 citations

The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface.

1990 • 221 citations

Human IgM molecules that bind staphylococcal protein A contain VHIII H chains.

1989 • 199 citations

Structure and evolution of mammalian V_H families

1990 • 177 citations

The galactan‐binding immunoglobulin Fab J539: An x‐ray diffraction study at 2.6‐Å resolution

1986 • 175 citations

The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. Further evidence that some autoantibodies are unmutated copies of germ line genes.

1990 • 174 citations

Evolutionary nucleotide replacements in DNA

1979 • 169 citations

The expression of the Ig H chain repertoire in developing bone marrow B lineage cells.

1991 • 95 citations

Conservation of an immunoglobulin variable-region gene family indicates a specific, noncoding function.

1989 • 87 citations

Three-dimensional structure of Fab R19.9, a monoclonal murine antibody specific for the p-azobenzenearsonate group.

1989 • 72 citations

Structural Patterns in Anti-DNA Antibodies from MRL/lpr Mice

1989 • 65 citations

Characterization of somatically mutated S107 VH11-encoded anti-DNA autoantibodies derived from autoimmune (NZB x NZW)F1 mice.

1991 • 50 citations