The Interplay Between Chemistry and Biology in the Design of Enzymatic Catalysts

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

Sequence-Specific Cleavage of Double Helical DNA by Triple Helix Formation

1987 • 1,275 citations

Entropic Contributions to Rate Accelerations in Enzymic and Intramolecular Reactions and the Chelate Effect

1971 • 980 citations

Design of Sequence-Specific DNA-Binding Molecules

1986 • 840 citations

Supramolecular Chemistry: Receptors, Catalysts, and Carriers

1985 • 778 citations

Asymmetric hydrogenation of .beta.-keto carboxylic esters. A practical, purely chemical access to .beta.-hydroxy esters in high enantiomeric purity

1987 • 732 citations

Three-Dimensional Structure of Immunoglobulins

1979 • 692 citations

Crystallographic studies of the activity of hen egg-white lysozyme

1967 • 649 citations

Selective Chemical Catalysis by an Antibody

1986 • 626 citations

Catalytic Antibodies

1986 • 581 citations

Phosphocholine binding immunoglobulin Fab McPC603

1986 • 576 citations

IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts

1981 • 509 citations

Cavitands: Organic Hosts with Enforced Cavities

1983 • 470 citations

The Three-Dimensional Structure of a Phosphorylcholine-Binding Mouse Immunoglobulin Fab and the Nature of the Antigen Binding Site

1974 • 465 citations

Enzymes as Catalysts in Synthetic Organic Chemistry [New Synthetic Methods (53)]

1985 • 450 citations

TRANSITION STATE ANALOG INHIBITORS AND ENZYME CATALYSIS

1976 • 415 citations

Catalytic Properties and Specificity of the Extracellular Nuclease of Staphylococcus aureus

1967 • 362 citations

Sequence specific cleavage of DNA by micrococcal nuclease

1981 • 319 citations

Artificial Enzymes

1982 • 318 citations

Chemical achievement and hope for the future.

1948 • 318 citations

Tinkering with Enzymes: What Are We Learning?

1987 • 304 citations

A hapten-specific chimaeric IgE antibody with human physiological effector function

1985 • 289 citations

[4] The preparation of antigenic Hapten-Carrier conjugates: A survey

1980 • 272 citations

Phosphonamidates as transition-state analog inhibitors of thermolysin

1983 • 265 citations

Model Substrates for an RNA Enzyme

1987 • 264 citations

Probing Steric and Hydrophobic Effects on Enzyme-Substrate Interactions by Protein Engineering

1986 • 240 citations

Chemical Mutation of Enzyme Active Sites

1984 • 199 citations

Transition-state stabilization and enzymic catalysis. Kinetic and molecular orbital studies of the rearrangement of chorismate to prephenate

1973 • 198 citations

Kinetic and magnetic resonance studies of active-site mutants of staphylococcal nuclease: factors contributing to catalysis

1987 • 168 citations

The Generation of Diversity in Phosphorylcholine-Binding Antibodies

1984 • 153 citations

Generation of a Hybrid Sequence-Specific Single-Stranded Deoxyribonuclease

1987 • 147 citations

Catalytic antibodies

1987 • 136 citations

Synthesis of a Sequence-Specific DNA-Cleaving Peptide

1987 • 134 citations

The structural basis of antibody specificity

1968 • 131 citations

An inhibitor of chorismate mutase resembling the transition-state conformation

1985 • 129 citations

Site-directed cleavage of RNA

1987 • 124 citations

The mechanism of the chorismate mutase reaction

1987 • 120 citations

Staphylococcal nuclease reviewed: A prototypic study in contemporary enzymology. I isolation; physical and enzymatic properties

1978 • 119 citations

Chemical Conversion of a DNA-Binding Protein into a Site-Specific Nuclease

1987 • 110 citations

INTRAMOLECULAR MODELS DEPICTING THE KINETIC IMPORTANCE OF „FIT” IN ENZYMATIC CATALYSIS

1960 • 107 citations

Secondary tritium isotope effects as probes of the enzymic and nonenzymic conversion of chorismate to prephenate

1983 • 104 citations

Stereochemistry of the rearrangement of chorismate to prephenate: chorismate mutase involves a chair transition state

1984 • 101 citations

The uncatalyzed Claisen rearrangement of chorismate to prephenate prefers a transition state of chair-like geometry

1985 • 82 citations

PHOTOSENSITIZED SPLITTING OF PYRIMIDINE DIMERS BY INDOLE DERIVATIVES AND BY TRYPTOPHAN‐CONTAINING OLIGOPEPTIDES AND PROTEINS

1977 • 71 citations

Flavin and 5-deazaflavin photosensitized cleavage of thymine dimer: a model of in vivo light-requiring DNA repair

1984 • 63 citations

Site-selective cleavage of RNA by a hybrid enzyme

1988 • 60 citations

Active Human-Yeast Chimeric Phosphoglycerate Kinases Engineered by Domain Interchange

1986 • 57 citations

Reversal of substrate charge specificity by site-directed mutagenesis of aspartate aminotransferase

1987 • 49 citations

Staphylococcal nuclease reviewed: A Prototypic study in contemporary enzymology. II. Solution studies of the nucleotide binding site and the effects of nucleotide binding.

1979 • 49 citations

Mapping of the Combining Sites of Antibodies specific for Poly-L-alanine Determinants

1970 • 40 citations

Monoclonal Antibodies: Their Chemistry, Functions, and Possible Uses

1985 • 34 citations

Orientational catalysis by cyclohexaamylose

1973 • 34 citations

24 Photoreactivating Enzymes

1981 • 33 citations

Radioimmunoassay of androstenedione: The steroid molecule as a probe for antibody specificity

1975 • 29 citations

Antibody Catalysis by Transition State Stabilization

1987 • 29 citations

Molecular studies of subspecificity differences among phosphorylcholine-binding mouse myeloma antibodies using phosphorus-31 nuclear magnetic resonance

1978 • 29 citations

THE CARBOHYDRATES OF GONOCOCCUS AND MENINGOCOCCUS

1934 • 21 citations

Reconstruction of rat skeletal muscle glycerophosphate shuttle

1979 • 5 citations