Solution structure of human and mouse immunoglobulin M by synchrotron X-ray scattering and molecular graphics modelling

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.

1981 • 1,432 citations

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-.ANG. resolution

1981 • 1,286 citations

Structural invariants in protein folding

1975 • 865 citations

Interactive computer graphics: FRODO

1985 • 848 citations

Hydrodynamic properties of complex, rigid, biological macromolecules: theory and applications

1981 • 614 citations

Phosphocholine binding immunoglobulin Fab McPC603

1986 • 576 citations

Protein volumes and hydration effects. The calculations of partial specific volumes, neutron scattering matchpoints and 280-nm absorption coefficients for proteins and glycoproteins from amino acid sequences

1986 • 575 citations

The binding site for C1q on IgG

1988 • 556 citations

Crystallographic refinement and atomic models of the intact immunoglobulin molecule Kol and its antigen-binding fragment at 3.0 Å and 1.9 Å resolution

1980 • 455 citations

Complement Fixation on Cell Surfaces by 19 S and 7 S Antibodies

1965 • 336 citations

X-ray small angle scattering with substances of biological interest in diluted solutions

1963 • 307 citations

Preliminary refinement and structural analysis of the Fab fragment from human immunoglobulin new at 2.0 A resolution.

1978 • 293 citations

Hydrodynamic properties of macromolecular complexes. I. Translation

1977 • 225 citations

The Coming of Age of the Immunoglobulin J Chain

1985 • 207 citations

Structure and function of the constant regions of immunoglobulins

1976 • 206 citations

Hemolysin Titration Based on Fixation of the Activated First Component of Complement: Evidence That One Molecule of Hemolysin Suffices to Sensitize an Erythrocyte

1965 • 185 citations

The C1q receptor site on immunoglobulin G

1980 • 161 citations

Initiation of complement activation

1984 • 160 citations

Conformation of the Free and Antigen-bound IgM Antibody Molecules

1969 • 139 citations

Immunoglobulin flexibility in complement activation

1986 • 135 citations

Time-resolved x-ray diffraction station: X-ray optics, detectors, and data acquisition

1989 • 132 citations

Immunoglobulin M: Pentameric Fcμ Fragments Released by Trypsin at Higher Temperatures

1970 • 126 citations

Complete structure and organization of immunoglobulin heavy chain constant region genes in a phylogenetically primitive vertebrate.

1988 • 122 citations

Immunochemical studies of the reaction between a mouse myeloma macroglobulin and dextrans

1970 • 116 citations

On the structure of polymeric IgM

1988 • 115 citations

Intermolecular disulfide bonding in IgM: effects of replacing cysteine residues in the mu heavy chain.

1989 • 104 citations

THE THREE‐DIMENSIONAL CONFORMATION OF γ M and γ A GLOBULIN MOLECULES

1971 • 99 citations

Low-resolution structural studies of mitochondrial ubiquinol: Cytochrome c reductase in detergent solutions by neutron scattering

1983 • 98 citations

Recent Developments in Solution X-Ray Scattering

1980 • 97 citations

IgM - molecular requirements for its assembly and function

1989 • 92 citations

Complete nucleotide sequence of an immunoglobulin heavy-chain gene and analysis of immunoglobulin gene organization in a primitive teleost species.

1990 • 90 citations

Structure and Role of the Five Glycopeptides of Human IgM Immunoglobulins

1971 • 90 citations

Amino acid sequence of heavy chain from Xenopus laevis IgM deduced from cDNA sequence: implications for evolution of immunoglobulin domains.

1988 • 84 citations

Unusual ultrastructure of complement-component-C4b-binding protein of human complement by synchrotron X-ray scattering and hydrodynamic analysis

1986 • 83 citations

Application of Ring Current Calculations to the Proton NMR of Proteins and Transfer RNA

1982 • 83 citations

Hydrodynamics of macromolecular complexes. III. Bacterial viruses

1977 • 82 citations

Shape and volume of anti-poly-D-alanyl antibodies in the presence and absence of tetra-D-alanine as followed by small-angle x-ray scattering

1973 • 79 citations

Macroglobulin-Producing Plasma-Cell Tumor in Mice: Identification of a New Light Chain

1965 • 79 citations

Studies on the reduction of a human 19<scp>s</scp> immunoglobulin M

1969 • 76 citations

Cloning and sequence analysis of channel catfish heavy chain cDNA indicate phylogenetic diversity within the IgM immunoglobulin family.

1989 • 74 citations

Dynamic properties of biomolecular assemblies

1990 • 71 citations

Functional affinity constants of the reaction between 125I-labelled C1q and C1q binders and their use in the measurement of plasma C1q concentrations.

1977 • 71 citations

Nucleotide sequence of channel catfish heavy chain cDNA and genomic blot analyses. Implications for the phylogeny of Ig heavy chains.

1989 • 68 citations

Molecular modelling of human complement component C3 and its fragments by solution scattering

1986 • 65 citations

Computer models of the human immunoglobulins shape and segmental flexibility

1986 • 62 citations

Two-domain structure of the native and reactive centre cleaved forms of C inhibitor of human complement by neutron scattering

1990 • 62 citations

Fixation of C' and C'la by rabbit gamma-G- and gamma-M-antibodies with particulate and soluble antigens.

1968 • 59 citations

Secondary structure of the immunoglobulin J chain.

1985 • 57 citations

Computer models of the human immunoglobulins

1986 • 56 citations

Interchain disulphide bridges of mouse immunoglobulin M

1975 • 55 citations

A molecular mechanism for the activation of the first component of complement by immune complexes

1986 • 55 citations

Structural studies of proteins by high-flux X-ray and neutron solution scattering

1988 • 53 citations

Facilities for solution scattering and fibre diffraction at the Daresbury SRS

1985 • 53 citations

Major carbohydrate structures at five glycosylation sites on murine IgM determined by high resolution 1H-NMR spectroscopy

1985 • 53 citations

Structural comparisons of the native and reactive-centre-cleaved forms of α1-antitrypsin by neutron- and X-ray-scattering in solution

1990 • 50 citations

Molecular modelling of human complement subcomponent C1q and its complex with C1r2C1s2 derived from neutron-scattering curves and hydrodynamic properties

1985 • 48 citations

Immunoglobulin M possesses two binding sites for complement subcomponent C1q, and soluble 1:1 and 2:1 complexes are formed in solution at reduced ionic strength.

1985 • 45 citations

Fixation of C′ and C′la by Rabbit γG- and γM-Antibodies with Particulate and Soluble Antigens

1968 • 43 citations

Protein Conformation as an Immunological Signal

1983 • 41 citations

Studies on a human 19-S immunoglobulin M The arrangement of inter-chain disulphide bridges and carbohydrate sites

1969 • 40 citations

C1 binding by mouse IgM. The effect of abnormal glycosylation at position 402 resulting from a serine to asparagine exchange at residue 406 of the mu-chain.

1990 • 39 citations

A model of the Fc of immunoglobulin E

1986 • 38 citations

Complement activation by IgM: evidence for the importance of the third constant domain of the μ heavy chain

1987 • 36 citations

C1 binding by murine IgM. The effect of a Pro-to-Ser exchange at residue 436 of the mu-chain.

1988 • 31 citations

The carbohydrate composition of J chain from human serum and secretory IgA

1972 • 30 citations

Formation of complement subcomponent C1q-immunoglobulin G complex. Thermodynamic and chemical-modification studies

1982 • 29 citations

Molecular modeling of human complement component C4 and its fragments by x-ray and neutron solution scattering

1990 • 27 citations

Activation of complement by immunoglobulin M is impaired by the substitution serine-406----asparagine in the immunoglobulin mu heavy chain.

1986 • 23 citations

Functional affinity constants of subfragments of immunoglobulin G for Clq

1982 • 23 citations

Structural studies of the asparagine-linked sugar chains of two immunoglobulin M's purified from a patient with Waldenström's macroglobulinemia

1989 • 19 citations

Immunoglobulin M Conformational Change is a Signal for Complement Activation

1983 • 17 citations

A monoclonal antibody with specificity for murine μ heavy chain which inhibits the formation of antigen-specific direct IgM plaques

1983 • 16 citations

Structure of hydrated immunoglobulins and antigen-antibody complexes. Electron microscopy of spray-freeze-etched specimens

1980 • 14 citations

A comparison of the proteolytic fragmentation of immunoglobulin M from several different mammalian species

1982 • 14 citations

Quaternary structure of immunoglobulin m: A model based on small-angle X-ray scattering data

1980 • 12 citations

Small-angle neutron scattering study of Bence-Jones protein Mcg: comparison of structures in solution and in crystal

1982 • 10 citations

Small-Angle X-Ray Studies of a Human Immunoglobulin M

1978 • 9 citations

Structural basis of the heterogeneity of asparagine-linked oligosaccharides of a waldenstrom's macroglobulinemia immunoglobulin M

1984 • 8 citations

Models for the C1 complex determined by physical techniques.

1989 • 6 citations

Molecular modelling strategies in application to complement

1990 • 6 citations

X-ray scattering of antibodies: the monomeric 8S subunit of human IgM

1984 • 3 citations

Electron Microscopy of Particles Related to the Immune System and Use of IgG for Specific Labelling: Review, Summary, and Perspectives

2015 • 1 citations

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