Properties of polyreactive natural antibodies to self and foreign antigens

Three-Dimensional Structure of an Antigen-Antibody Complex at 2.8 Å Resolution

1986 • 1,173 citations

Naturally occurring antibodies against nine common antigens in human sera. I. Detection, isolation and characterization.

1982 • 665 citations

Human Lymphocytes Making Rheumatoid Factor and Antibody to ssDNA Belong to Leu-1⁺B-Cell Subset

1987 • 490 citations

Rheumatoid Factor Secretion from Human Leu-1 ⁺ B Cells

1987 • 442 citations

High frequency of natural autoantibodies in normal newborn mice.

1985 • 387 citations

Mechanism of removal of senescent cells by human macrophages in situ.

1975 • 345 citations

Probing the Human B-Cell Repertoire with EBV: Polyreactive Antibodies and CD5+ B Lymphocytes

1989 • 330 citations

Three-dimensional structure of an antigen–antibody complex at 6 Å resolution

1985 • 305 citations

Production of autoantibodies by CD5-expressing B lymphocytes from patients with chronic lymphocytic leukemia.

1989 • 290 citations

Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia.

1989 • 239 citations

Nucleotide sequences of eight human natural autoantibody VH regions reveals apparent restricted use of VH families.

1989 • 234 citations

Mls — a retrovirus exploits the immune system

1991 • 233 citations

Murine Natural Monoclonal Autoantibodies: A Study of their Polyspecificities and their Affinities

1986 • 215 citations

Autoantibodies and the physiological role of immunoglobulins

1983 • 203 citations

A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus.

1986 • 197 citations

A new human immunoglobulin VH family preferentially rearranged in immature B-cell tumours

1988 • 174 citations

Rheumatoid Factor and Immune Networks

1987 • 168 citations

Idiotype‐Directed Interactions during Ontogeny Play a Major Role in the Establishment of the Adult B Cell Repertoire

1986 • 166 citations

Two murine natural polyreactive autoantibodies are encoded by nonmutated germ-line genes.

1989 • 149 citations

Natural autoantibodies might prevent autoimmune disease

1986 • 136 citations

Anti-DNA autoantibody-producing hybridomas of normal human lymphoid cell origin.

1984 • 135 citations

Analysis of variable region genes encoding a human anti-DNA antibody of normal origin. Implications for the molecular basis of human autoimmune responses.

1989 • 115 citations

Immunoglobulin V_H gene expression in human B cell lines and tumors: biased V_H gene expression in chronic lymphocytic leukemia

1989 • 112 citations

Autoantibodies encoded by the most Jh-proximal human immunoglobulin heavy chain variable region gene.

1989 • 107 citations

V Genes Encoding Autoantibodies: Molecular and Phenotypic Characteristics

1988 • 89 citations

The genetic origin of autoantibodies

1987 • 83 citations

Hybrids from normal, germ free, nude and neonatal mice produce monoclonal autoantibodies to eight different intracellular structures.

1985 • 80 citations

Natural antibodies and autoimmunity

1985 • 79 citations

Recognition of Self and Non-Self Constituents by Polyspecific Autoreceptors

1988 • 65 citations

Presence of natural autoantibodies in hyperimmunized mice.

1985 • 48 citations

Genetic Origin Of Human Autoantibodies

2002 • 46 citations

The genetic origin of human autoantibodies.

1988 • 38 citations

Analysis of the human tonsil B cell repertoire by somatic hybridization: occurrence of both “monospecific” and “multispecific” (auto)antibody‐secreting cells

1987 • 24 citations

Immunochemical studies of polyspecific natural autoantibodies: Charge, lipid reactivity, Fab'2 fragments activity and complement fixation

1988 • 22 citations

Polyvalent Anti-DNA Autoantibodies: Immunochemical and Biological Significance

1988 • 18 citations