Structure and function of the constant regions of immunoglobulins

Atlas of protein sequence and structure

1965 • 4,462 citations

Atlas of Protein Sequence and Structure, 1972.

1973 • 2,408 citations

The hydrolysis of rabbit γ-globulin and antibodies with crystalline papain

1959 • 2,294 citations

Separation of univalent fragments from the bivalent rabbit antibody molecule by reduction of disulfide bonds

1960 • 901 citations

THE COVALENT STRUCTURE OF AN ENTIRE γG IMMUNOGLOBULIN MOLECULE

1969 • 869 citations

Three-Dimensional Structure of Immunoglobulins

1979 • 692 citations

The Three-Dimensional Structure of a Phosphorylcholine-Binding Mouse Immunoglobulin Fab and the Nature of the Antigen Binding Site

1974 • 465 citations

Structure of the Carbohydrate Units of IgA1 Immunoglobulin

1974 • 382 citations

Three-Dimensional Structure of the Fab′ Fragment of a Human Immunoglobulin at 2.8-Å Resolution

1973 • 381 citations

Structure of a λ-type Bence-Jones protein at 3.5-Å resolution

1973 • 356 citations

The Antibody Problem

1969 • 347 citations

Human Immunoglobulins: Classes, Subclasses, Genetic Variants, and Idiotypes

1973 • 333 citations

Complete Amino Acid Sequence of the Mu Heavy Chain of a Human IgM Immunoglobulin

1973 • 270 citations

Molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI refined at 2.0-Å resolution

1975 • 266 citations

The Three-Dimensional Structure at 6 A Resolution of a Human γG1 Immunoglobulin Molecule

1971 • 249 citations

Crystal and Molecular Structure of a Dimer Composed of the Variable Portions of the Bence-Jones Protein REI

1974 • 231 citations

Three-Dimensional Structure of Immunoglobulins

1975 • 218 citations

Rotational allomerism and divergent evolution of domains in immunoglobulin light chains

1975 • 217 citations

The Three-Dimensional Structure of the Fab′ Fragment of a Human Myeloma Immunoglobulin at 2.0-Å Resolution

1974 • 213 citations

Structure and Function of γ Macroglobulins

1970 • 206 citations

Hypervariable Regions, Idiotypy, and the Antibody-Combining Site

1975 • 201 citations

Molecular Mechanism of Formation of an Antigen–Antibody Complex

1965 • 184 citations

Effect of Antigen Binding on the Properties of Antibody

1974 • 182 citations

Structure and Function of the J Chain

1975 • 172 citations

Structure and biological properties of immunoglobulins

1967 • 166 citations

Contemporary topics in molecular immunology

1974 • 158 citations

The structure and function of immunoglobulin domains. II. The importance of interchain disulfide bonds and the possible role of molecular flexibility in the interaction between immunoglobulin G and complement.

1975 • 154 citations

Active antibody fragment (Fv) composed of the variable portions of heavy and light chains

1973 • 151 citations

Structure of the human antibody molecule kol (immunoglobulin G1): An electron density map at 5 Å resolution

1976 • 148 citations

Rabbit Immunoglobulin Allotypes: Structure, Immunology, and Genetics

1975 • 147 citations

Immunoglobulin Peptide with Complement Fixing Activity

1969 • 130 citations

Electron Mircroscopy of the Immunoglobulins

1969 • 130 citations

Immunoglobulin M: Pentameric Fcμ Fragments Released by Trypsin at Higher Temperatures

1970 • 126 citations

Characterization of a plasmin-digest fragment of rabbit immunoglobulin gamma that binds antigen and complement

1975 • 126 citations

Variations in Amino-Acid Sequence Near the Disulphide Bridges of Bence-Jones Proteins

1966 • 124 citations

Subfragments from the Fc fragment of human immunoglobulin G. Isolation and physicochemical characterization

1968 • 116 citations

The Immunoglobulin a System

1974 • 113 citations

Allelic Antigenic Factor Inv(a) of the Light Chains of Human Immunoglobulins: Chemical Basis

1966 • 113 citations

Stepwise cleavage of rabbit immunoglobin G by papain and isolation of four types of biologically active Fc fragments

1969 • 112 citations

Antigen-induced conformational changes in antibodies and their Fab fragments studied by circular polarization of fluorescence.

1975 • 106 citations

THE THREE‐DIMENSIONAL CONFORMATION OF γ M and γ A GLOBULIN MOLECULES

1971 • 99 citations

THE FIXATION OF COMPLEMENT AND THE ACTIVATED FIRST COMPONENT (C1) OF COMPLEMENT BY COMPLEXES FORMED BETWEEN ANTIBODY AND DIVALENT HAPTEN

1970 • 97 citations

A new enzymic fragment (Facb) of rabbit immunoglobulin G

1971 • 90 citations

A fragment corresponding to the C_H2 region of immunoglobulin G (IgG) with complement fixing activity

1972 • 89 citations

The Structure and Function of Immunoglobulin Domains

1975 • 87 citations

Structure and function of immunoglobulin domains. VII. Studies on the structural requirements of human immunoglobulin G for granulocyte binding.

1978 • 86 citations

Complement fixation by the F(ab')2-fragment of pepsin-treated rabbit antibody.

1971 • 82 citations

Three-dimensional structure, function and genetic control of immunoglobulins

1975 • 80 citations

Two types of lambda polypeptide chains in human immunoglobulins based on an amino acid substitution at position 190.

1967 • 77 citations

Studies on the reduction of a human 19<scp>s</scp> immunoglobulin M

1969 • 76 citations

Structural Variants of Human and Murine Immunoglobulins

1975 • 71 citations

Activation of antibody Fc function by antigen-induced conformational changes.

1975 • 70 citations

Localisation of Monocyte Binding Site of Human Immunoglobulin G

1974 • 68 citations

X-Ray Diffraction Studies of Immunoglobulins

1975 • 64 citations

Structure, Function, and Evolutionary Relationships of Fc Domains of Human Immunoglobulins A, G, M, and E

1976 • 63 citations

Evidence for the Domain Hypothesis: Location of the Site of Cytophilic Activity toward Guinea Pig Macrophages in the CH3 Homology Region of Human Immunoglobulin G

1973 • 59 citations

The structure and function of immunoglobulin domains: studies with beta-2-microglobulin on the role of the intrachain disulfide bond.

1975 • 58 citations

Crystallographic Structural Studies of a Human Fc-Fragment. I. An Electron-Density Map at 4 Å Resolution and a Partial Model

1976 • 57 citations

Variability of three-dimensional structure in immunoglobulins.

1975 • 56 citations

Interchain disulphide bridges of mouse immunoglobulin M

1975 • 55 citations

Structure and regulation of immunoglobulins: kappa allotypes in the rat have multiple amino-acid differences in the constant region.

1975 • 49 citations

Effector activating determinants on IgG. II. Differentiation of the combining sites for C1q from those for cytotoxic K cells and neutrophils by plasmin digestion of rabbits IgG.

1974 • 48 citations

Isotypes in Human Immunoglobulin λ-Chains

1971 • 47 citations

Fixation of the first component of complement by immune complexes: effect of reduction and fragmentation of antibody

1975 • 47 citations

A Crystallographic Investigation of a Human IgG Immunoglobulin

1970 • 47 citations

ANTIBODY STRUCTURE AND MOLECULAR IMMUNOLOGY*

1971 • 46 citations

The J Chain of Polymeric Immunoglobulins

1974 • 42 citations

Circular dichroism studies on the variable and constant halves of kappa-type Bence-Jones proteins

1971 • 42 citations

Immunoglobulin M: Fixation of Human Complement by the Fc Fragment

1972 • 41 citations

Immunoglobulin Structures at High Resolution

1975 • 40 citations

THE STRUCTURAL BASIS FOR BINDING OF COMPLEMENT BY IMMUNOGLOBULIN M

1974 • 37 citations

Studies on the Variability of Immunoglobulin Sequence

1967 • 35 citations

The Structure and Mechanism of Activation of the First Component of Complement

1975 • 34 citations

Independent Folding of the Variable and Constant Halves of a Lambda Immunoglobulin Light Chain

1971 • 33 citations

CH3 domain of IgG as binding site to Fc receptor on mouse lymphocytes

1975 • 31 citations

Different degrees of interspecies homology in immunoglobulin λ chain constant domain correlated with three-dimensional structure

1975 • 31 citations

β2-Microglobulins

1975 • 30 citations

Complement activation by a univalent hapten-antibody complex.

1975 • 29 citations

Human Fc fragment: Crystallographic evidence for two equivalent subunits

1968 • 29 citations

Determination of the Primary Structure of a Mouse IgG2a Immunoglobulin: Amino‐Acid Sequence of the Fc Fragment

1974 • 27 citations

Structural studies of an Inv (1, −2) kappa light chain

1974 • 27 citations

Metabolism of Immunoglobulins

1971 • 24 citations

Conformational studies on subfragments from the Fc region of human immunoglobulin G

1972 • 22 citations

Structure and Biosynthesis of Antibodies

1980 • 20 citations

A re-examination of the ability of pFc′ and Fc′ to participate in passive cutaneous anaphylaxis

1972 • 18 citations

Mouse Immunoglobulin Subclasses: Cyanogen Bromide Fragments and Partial Sequence of a gamma1 Chain

1975 • 17 citations

A porcine immunoglobulin Fcμ polymer that has no J chain

1974 • 17 citations

Determination of the Primary Structure of a Mouse IgG2a Immunoglobulin

1975 • 16 citations

Primary structure of the CH3 homology region from guinea pig IgG2 antibodies

1974 • 16 citations

Production of a Noncovalently Bonded Pentamer of Immunoglobulin M: Relationship to J Chain

1973 • 16 citations

Primary structure of the CH2 homology region from guinea pig IgG2 antibodies

1974 • 16 citations

The Variation and Adaptive Expression of Antibodies.

1974 • 16 citations

Immunoglobulin A. Arrangement of disulfide bridges in the hinge region of an immunoglobulin A1 human myeloma protein

1973 • 16 citations

The Primary Structure of a Tetradecapeptide Containing the Cysteine Residue Linking γM-Globulin Subunits

1970 • 14 citations

The Variation and Adaptive Expression of Antibodies

1973 • 13 citations

Fragmentation and reduction of porcine 19 S immunoglobulin M

1974 • 13 citations

Non-covalent association of IgM subunits produced by reduction and alkylation.

1974 • 13 citations

Gamma globulins ; structure and biosynthesis

1969 • 12 citations

Recovery of the native conformations of the variable and constant halves of an immunoglobulin light chain upon renaturation from the linear random coil state

1972 • 12 citations

Reversible dissociation of reduced subunits of human γM-globulins into 5 S component

1971 • 12 citations

Contemporary Topics in Molecular Immunology

1975 • 12 citations

Peptic digestion of pig IgM

1974 • 12 citations

Evidence for C‐terminal intra‐subunit disulphide bridges between immunoglobulin‐M heavy chains

1970 • 11 citations

The specificity of the Fc receptor on murine lymphocytes for immunoglobulins of the IgG and IgM classes.

1976 • 11 citations

X‐ray studies on antibody fragments

1974 • 10 citations

Modulation of the Assembly of Immunoglobulin Subunits by J Chain

1974 • 8 citations

The Cγ3 Homology Region in Human IgG Subclasses and Allotypes

1974 • 8 citations

An Atypical Human Immunoglobulin G with Deletions in both Heavy and Light Chains. Studies of the Conformation and the In Vitro Recombination of the Isolated Subunits

1974 • 5 citations

Structural studies of a human immunoglobulin M: Localization of a third light chain

1975 • 4 citations

Complement fixation by pig immunoglobulin M and its enzymic fragments

1976 • 4 citations

Structure and biosynthesis of antibodies

1973 • 3 citations

Chemical structure of immunoglobulins

1966 • 2 citations