Probing antibody diversity by 2D NMR: comparison of amino acid sequences, predicted structures, and observed antibody-antigen interactions in complexes of two antipeptide antibodies

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

Canonical structures for the hypervariable regions of immunoglobulins

1987 • 1,357 citations

AN ANALYSIS OF THE SEQUENCES OF THE VARIABLE REGIONS OF BENCE JONES PROTEINS AND MYELOMA LIGHT CHAINS AND THEIR IMPLICATIONS FOR ANTIBODY COMPLEMENTARITY

1970 • 1,308 citations

Three-Dimensional Structure of an Antigen-Antibody Complex at 2.8 Å Resolution

1986 • 1,173 citations

Three-dimensional structure of an antibody-antigen complex.

1987 • 615 citations

The Three-Dimensional Structure of a Phosphorylcholine-Binding Mouse Immunoglobulin Fab and the Nature of the Antigen Binding Site

1974 • 465 citations

Crystallographic refinement and atomic models of the intact immunoglobulin molecule Kol and its antigen-binding fragment at 3.0 Å and 1.9 Å resolution

1980 • 455 citations

Theory and applications of the transferred nuclear overhauser effect to the study of the conformations of small ligands bound to proteins

1982 • 392 citations

Protein folding by restrained energy minimization and molecular dynamics

1983 • 371 citations

Preliminary refinement and structural analysis of the Fab fragment from human immunoglobulin new at 2.0 A resolution.

1978 • 293 citations

Theory of the time dependent transferred nuclear Overhauser effect: Applications to structural analysis of ligand-protein complexes in solution

1983 • 285 citations

Complete sequence of constant and 3′ noncoding regions of an immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing

1978 • 211 citations

Negative nuclear Overhuaser effects as probes of macromolecular structure

1972 • 209 citations

The Predicted Structure of Immunoglobulin D1.3 and Its Comparison with the Crystal Structure

1986 • 206 citations

Structure of antibody hypervariable loops reproduced by a conformational search algorithm

1988 • 200 citations

The galactan‐binding immunoglobulin Fab J539: An x‐ray diffraction study at 2.6‐Å resolution

1986 • 175 citations

Members of novel VH gene families are found in VDJ regions of polyclonally activated B-lymphocytes.

1985 • 147 citations

Alignment of the amino acid sequences of distantly related proteins using variable gap penalties

1986 • 118 citations

The use of transferred nuclear Overhauser effects in the study of the conformations of small molecules bound to proteins

1979 • 113 citations

Interactions of antibody aromatic residues with a peptide of cholera toxin observed by two-dimensional transferred nuclear Overhauser effect difference spectroscopy

1989 • 53 citations

NMR technique for assessing contributions of heavy and light chains to an antibody combining site

1985 • 50 citations

Complete amino acid sequence of heavy chain variable regions derived from two monoclonal anti-p-azophenylarsonate antibodies of BALB/c mice expressing the major cross-reactive idiotype of the A/J strain.

1984 • 49 citations

NMR study of the complexes between a synthetic peptide derived from the B subunit of cholera toxin and three monoclonal antibodies against it

1988 • 45 citations

Contribution of tryptophan residues to the combining site of a monoclonal anti-dinitrophenyl spin-label antibody

1987 • 38 citations

Monoclonal BALB/c anti‐progesterone antibodies use family IX variable region heavy chain genes

1987 • 33 citations

Polymorphism of kappa variable region (V kappa-1) genes in inbred mice: relationship to the Ig kappa-Ef2 serum light chain marker.

1985 • 18 citations

Crystallization and preliminary crystallographic data for an antiprogesterone monoclonal antibody Fab′ and steroid-Fab′ complexes

1987 • 16 citations

Proton nuclear magnetic resonance studies of Bence-Jones proteins

1979 • 13 citations

Proton nuclear magnetic resonance studies of human immunoglobulins. Solution conformation of the constant domain of the .lambda. light chains and identification of the isotypes

1980 • 11 citations