SUMOylation Code in Cancer Development and Metastasis

Mechanisms Underlying Ubiquitination

2001 • 3,555 citations

NF-κB: linking inflammation and immunity to cancer development and progression

2005 • 2,878 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

Protein Modification by SUMO

2004 • 1,628 citations

SUMO

2005 • 1,562 citations

Ubiquitin ligases: cell-cycle control and cancer

2006 • 1,392 citations

Ubiquitin: structures, functions, mechanisms

2004 • 1,308 citations

Post-translational modification of p53 in tumorigenesis

2004 • 1,227 citations

SUMO-1 Modification of IκBα Inhibits NF-κB Activation

1998 • 1,002 citations

p53 Ubiquitination: Mdm2 and Beyond

2006 • 865 citations

Functional Heterogeneity of Small Ubiquitin-related Protein Modifiers SUMO-1 versus SUMO-2/3

2000 • 848 citations

Ubiquitin and ubiquitin-like proteins as multifunctional signals

2005 • 801 citations

The Nucleoporin RanBP2 Has SUMO1 E3 Ligase Activity

2002 • 787 citations

Polymeric Chains of SUMO-2 and SUMO-3 Are Conjugated to Protein Substrates by SAE1/SAE2 and Ubc9

2001 • 782 citations

SUMO—Nonclassical Ubiquitin

2000 • 764 citations

SUMO-1 Conjugation in Vivo Requires Both a Consensus Modification Motif and Nuclear Targeting

2001 • 722 citations

SUMO-1 modification activates the transcriptional response of p53

1999 • 627 citations

Drug discovery in the ubiquitin–proteasome system

2006 • 597 citations

The Polycomb Protein Pc2 Is a SUMO E3

2003 • 558 citations

Exchange of N-CoR Corepressor and Tip60 Coactivator Complexes Links Gene Expression by NF-κB and β-Amyloid Precursor Protein

2002 • 554 citations

The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer

1997 • 543 citations

Sequential Modification of NEMO/IKKγ by SUMO-1 and Ubiquitin Mediates NF-κB Activation by Genotoxic Stress

2003 • 542 citations

PIASy, a nuclear matrix–associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies

2001 • 538 citations

Spontaneous and carcinogen–induced tumorigenesis in p53–deficient mice

1993 • 537 citations

Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1

1999 • 507 citations

Ubc9p Is the Conjugating Enzyme for the Ubiquitin-like Protein Smt3p

1997 • 488 citations

Ubiquitin-like proteins: new wines in new bottles

2000 • 474 citations

Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1)

2000 • 448 citations

Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity

2002 • 441 citations

Nedd8 on cullin: building an expressway to protein destruction

2004 • 423 citations

PIAS Proteins Modulate Transcription Factors by Functioning as SUMO-1 Ligases

2002 • 420 citations

c-Jun and p53 Activity Is Modulated by SUMO-1 Modification

2000 • 394 citations

SUMO: ligases, isopeptidases and nuclear pores

2003 • 387 citations

Identification of the Enzyme Required for Activation of the Small Ubiquitin-like Protein SUMO-1

1999 • 353 citations

Ubch9 conjugates SUMO but not ubiquitin

1997 • 349 citations

Estrogens and breast cancer

1996 • 343 citations

Transcriptional regulation of a metastasis suppressor gene by Tip60 and β-catenin complexes

2005 • 291 citations

NF‐κB and cancer: Mechanisms and targets

2006 • 286 citations

Enzymes of the SUMO Modification Pathway Localize to Filaments of the Nuclear Pore Complex

2002 • 279 citations

SP-RING for SUMO

2001 • 279 citations

Differential Regulation of Sentrinized Proteins by a Novel Sentrin-specific Protease

2000 • 266 citations

Lingering Mysteries of Ubiquitin-Chain Assembly

2006 • 253 citations

In VitroSUMO-1 Modification Requires Two Enzymatic Steps, E1 and E2

1999 • 224 citations

Sumoylation of the Estrogen Receptor α Hinge Region Regulates Its Transcriptional Activity

2005 • 222 citations

PIASy mediates NEMO sumoylation and NF-κB activation in response to genotoxic stress

2006 • 213 citations

The ubiquitin-like proteins SMT3 and SUMO-1 are conjugated by the UBC9 E2 enzyme

1998 • 210 citations

Role of Desumoylation in the Development of Prostate Cancer

2006 • 209 citations

PIAS1 and PIASxα Function as SUMO-E3 Ligases toward Androgen Receptor and Repress Androgen Receptor-dependent Transcription

2002 • 208 citations

Mutual interactions between the SUMO and ubiquitin systems: a plea of no contest

2005 • 196 citations

Down-Regulation of c-Fos/c-Jun AP-1 Dimer Activity by Sumoylation

2005 • 182 citations

A role for Ubc9 in tumorigenesis

2005 • 180 citations

Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin‐activating enzyme complex

1999 • 172 citations

SENP1 Enhances Androgen Receptor-Dependent Transcription through Desumoylation of Histone Deacetylase 1

2004 • 170 citations

A novel mammalian Smt3‐specific isopeptidase 1 (SMT3IP1) localized in the nucleolus at interphase

2000 • 168 citations

Versatile protein tag, SUMO: Its enzymology and biological function

2002 • 163 citations

Regulating the Regulators: Control of Protein Ubiquitination and Ubiquitin-like Modifications by Extracellular Stimuli

2005 • 156 citations

Novel NEMO/IκB Kinase and NF-κB Target Genes at the Pre-B to Immature B Cell Transition

2001 • 154 citations

Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis

2006 • 148 citations

Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas.

2002 • 146 citations

A New SUMO-1-specific Protease, SUSP1, That Is Highly Expressed in Reproductive Organs

2000 • 142 citations

The Nuclear Receptor Interaction Domain of GRIP1 Is Modulated by Covalent Attachment of SUMO-1

2002 • 136 citations

Functional analysis and intracellular localization of p53 modified by SUMO-1

2001 • 131 citations

MDM2-ARF complex regulates p53 sumoylation

2003 • 124 citations

NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression

2006 • 106 citations

Two-Step Differential Expression Analysis Reveals a New Set of Genes Involved in Thyroid Oncocytic Tumors

2005 • 104 citations

P14ARF promotes accumulation of SUMO‐1 conjugated (H)Mdm2

2002 • 94 citations

Ubiquitin-like protein activation

2004 • 82 citations

Balance of Yin and Yang: Ubiquitylation-Mediated Regulation of p53 and c-Myc

2006 • 81 citations

Targeting Ubc9 for cancer therapy

2005 • 80 citations

SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination

2006 • 72 citations

Differential Effect of Small Ubiquitin-Like Modifier (SUMO)-ylation of the Androgen Receptor in the Control of Cooperativity on SelectiveVersusCanonical Response Elements

2004 • 70 citations

Negative Modulation of RXRα Transcriptional Activity by Small Ubiquitin-related Modifier (SUMO) Modification and Its Reversal by SUMO-specific Protease SUSP1

2006 • 68 citations

The ubiquitin–proteasome system and cancer

2005 • 61 citations

A Novel Link Between SUMO Modification and Cancer Metastasis

2006 • 58 citations

MafG Sumoylation Is Required for Active Transcriptional Repression

2006 • 56 citations

SUMOylation of the Corepressor N-CoR Modulates Its Capacity to Repress Transcription

2006 • 54 citations

Sumoylated SnoN Represses Transcription in a Promoter-specific Manner

2006 • 52 citations

SUMO Modification Enhances p66-Mediated Transcriptional Repression of the Mi-2/NuRD Complex

2006 • 50 citations

RBP1 Family Proteins Exhibit SUMOylation-Dependent Transcriptional Repression and Induce Cell Growth Inhibition Reminiscent of Senescence

2006 • 44 citations

The ubiquitin–proteasome system and cancer

2005 • 40 citations