Selenomethionine regulation of p53 by a ref1-dependent redox mechanism

Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group

1996 • 2,404 citations

Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin

1996 • 1,807 citations

[21] Thioredoxin and thioredoxin reductase

1995 • 932 citations

Apoptosis, p53, and tumor cell sensitivity to anticancer agents.

1999 • 708 citations

Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair

1999 • 571 citations

Going APE over ref-1

2000 • 529 citations

Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.

1995 • 491 citations

Identification of redox/repair protein Ref-1 as a potent activator of p53.

1997 • 479 citations

Thioredoxin-dependent Redox Regulation of p53-mediated p21 Activation

1999 • 433 citations

p53-Mediated DNA Repair Responses to UV Radiation: Studies of Mouse Cells Lacking p53, p21, and/orgadd45 Genes

2000 • 422 citations

Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage.

1995 • 365 citations

RESPONSIVENESS OF SELENOPROTEINS TO DIETARY SELENIUM,

1999 • 358 citations

Removal of oxygen free-radical-induced 5′,8-purine cyclodeoxynucleosides from DNA by the nucleotide excision-repair pathway in human cells

2000 • 344 citations

Role of Cysteine Residues in Regulation of p53 Function

1995 • 301 citations

Selenium compounds have disparate abilities to impose oxidative stress and induce apoptosis

1999 • 299 citations

Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents.

1996 • 298 citations

Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo

1999 • 241 citations

Enhancement of DNA repair in human skin cells by thymidine dinucleotides: Evidence for a p53-mediated mammalian SOS response

1997 • 210 citations

Inhibitory effect of selenomethionine on the growth of three selected human tumor cell lines

1998 • 206 citations

Selenium-induced inhibition of angiogenesis in mammary cancer at chemopreventive levels of intake

1999 • 203 citations

Genotoxic and non-genotoxic pathways of p53 induction

2001 • 167 citations

Phosphorylation of murine p53 at Ser-18 regulates the p53 responses to DNA damage

2000 • 164 citations

p53 regulation of DNA excision repair pathways

2002 • 160 citations

Dissociation of the genotoxic and growth inhibitory effects of selenium

1995 • 154 citations

Prophylaxis of mammary neoplasia by selenium supplementation in the initiation and promotion phases of chemical carcinogenesis.

1981 • 132 citations

Inhibition of DNA cytosine methyltransferase by chemopreventive selenium compounds, determined by an improved assay for DNA cytosine methyltransferase and DNA cytosine methylation

1998 • 126 citations

BRCA1 Regulates GADD45 through Its Interactions with the OCT-1 and CAAT Motifs

2002 • 125 citations

Human fibroblasts expressing the human papillomavirus E6 gene are deficient in global genomic nucleotide excision repair and sensitive to ultraviolet irradiation.

1998 • 120 citations

Selenomethionine induction of DNA repair response in human fibroblasts

2002 • 117 citations

Mismatch Binding Protein-Based Mutation Detection Systems

1995 • 111 citations

Dimethylbenzanthracene carcinogenesis in Gadd45a-null mice is associated with decreased DNA repair and increased mutation frequency.

2001 • 107 citations

Organic and inorganic selenium compounds inhibit mouse mammary cell growth in vitro by different cellular pathways

1996 • 97 citations

p53-dependent global genomic repair of benzo[a]pyrene-7,8-diol-9,10-epoxide adducts in human cells.

2000 • 94 citations

The causes and prevention of cancer: gaining perspective.

1997 • 86 citations

Mutational inactivation of the xeroderma pigmentosum group C gene confers predisposition to 2-acetylaminofluorene-induced liver and lung cancer and to spontaneous testicular cancer in Trp53-/- mice.

1999 • 74 citations

Pyrrolidine Dithiocarbamate Prevents p53 Activation and Promotes p53 Cysteine Residue Oxidation

1998 • 68 citations

Decreased DNA Repair Efficiency by Loss or Disruption of p53 Function Preferentially Affects Removal of Cyclobutane Pyrimidine Dimers from Non-transcribed Strand and Slow Repair Sites in Transcribed Strand

2000 • 59 citations

Development of a Sensitive Assay to Detect Reversibly Oxidized Protein Cysteine Sulfhydryl Groups

2001 • 57 citations

Selenium-enriched Agaricus bisporus mushrooms suppress 7,12-dimethlybenz[a]anthracene bioactivation in mammary tissue

1999 • 55 citations

Selenium and prostate cancer prevention.

1999 • 54 citations

Chemoprevention of colon carcinogenesis by dietary organoselenium, benzylselenocyanate, in F344 rats.

1987 • 42 citations

p53-dependent signaling sustains DNA replication and enhances clonogenic survival in 254 nm ultraviolet-irradiated human fibroblasts.

1998 • 39 citations

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