Bacterial cupredoxin azurin as an inducer of apoptosis and regression in human breast cancer

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

Cancer Statistics, 2002

2002 • 2,954 citations

p53 Has a Direct Apoptogenic Role at the Mitochondria

2003 • 1,735 citations

Apoptosis Signaling

2000 • 1,290 citations

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1993 • 1,144 citations

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1998 • 1,100 citations

Death Signal-induced Localization of p53 Protein to Mitochondria

2000 • 883 citations

Substrate Specificities of Caspase Family Proteases

1997 • 871 citations

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

1998 • 843 citations

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

1999 • 750 citations

Natural products in anticancer therapy

2001 • 602 citations

Combination bacteriolytic therapy for the treatment of experimental tumors

2001 • 532 citations

Caspase-3 Is Required for α-Fodrin Cleavage but Dispensable for Cleavage of Other Death Substrates in Apoptosis

1998 • 484 citations

BCG immunotherapy of bladder cancer: 20 years on

1999 • 469 citations

Caspases: their intracellular localization and translocation during apoptosis

1999 • 358 citations

Peptide and protein drug delivery to and into tumors: challenges and solutions

2003 • 354 citations

Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1

2001 • 297 citations

Molecular targets for breast cancer therapy and prevention

2001 • 292 citations

Phagocytosis and cytolysis by a macrophage tumour and its cloned cell line

1975 • 259 citations

Different Subcellular Distribution of Caspase-3 and Caspase-7 following Fas-induced Apoptosis in Mouse Liver

1998 • 236 citations

Apoptosis in the absence of caspase 3

2001 • 231 citations

Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF‐7 human breast cancer cell

2002 • 230 citations

Epothilones and related structures – a new class of microtubule inhibitors with potent in vivo antitumor activity

2000 • 193 citations

Desoxyepothilone B: An efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B

1998 • 192 citations

Apoptotic mechanisms in T47D and MCF-7 human breast cancer cells

2002 • 182 citations

Bacterial redox protein azurin, tumor suppressor protein p53, and regression of cancer

2002 • 177 citations

Connective Tissue Growth Factor Induces Apoptosis in Human Breast Cancer Cell Line MCF-7

1999 • 176 citations

Use of preferentially replicating bacteria for the treatment of cancer

2000 • 164 citations

Structural Features of Peptide Analogs of Human Histocompatibility Leukocyte Antigen Class I Epitopes That Are More Potent and Immunogenic than Wild-Type Peptide

2001 • 147 citations

p53 Suppresses the Activation of the Bcl-2 Promoter by the Brn-3a POU Family Transcription Factor

1999 • 146 citations

Intracellular triggering of Fas, independently of FasL, as a new mechanism of antitumor ether lipid-induced apoptosis

2000 • 141 citations

Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells

2001 • 134 citations

Caspases 3 and 9 Send a Pro-Apoptotic Signal from Synapse to Cell Body in Olfactory Receptor Neurons

2001 • 131 citations

Genistein induces apoptosis and topoisomerase II-mediated DNA breakage in colon cancer cells

2000 • 129 citations

The Baxα:Bcl-2 ratio modulates the response to dexamethasone in leukaemic cells and is highly variable in childhood acute leukaemia

1997 • 125 citations

Caspase‐3 is not essential for DNA fragmentation in MCF‐7 cells during apoptosis induced by the pyrrolo‐1,5‐benzoxazepine, PBOX‐6

2002 • 105 citations

The Bacterial Redox Protein Azurin Induces Apoptosis in J774 Macrophages through Complex Formation and Stabilization of the Tumor Suppressor Protein p53

2002 • 91 citations

Rapid onset of nucleolar disintegration preceding cell cycle arrest in roscovitine‐induced apoptosis of human MCF‐7 breast cancer cells

2003 • 79 citations

BCG in cancer immunotherapy

1976 • 79 citations

Microorganisms and Cancer: Quest for a Therapy

2003 • 78 citations

Cutting Edge: Systemic Inhibition of Angiogenesis Underlies Resistance to Tumors During Acute Toxoplasmosis

2001 • 74 citations

Induction of apoptosis in macrophages by Pseudomonas aeruginosa azurin: tumour‐suppressor protein p53 and reactive oxygen species, but not redox activity, as critical elements in cytotoxicity

2003 • 66 citations

Formation of nuclear Bax/p53 complexes is associated with chemotherapy induced apoptosis

2000 • 58 citations

Caspase activation in response to cytotoxic Rana catesbeiana ribonuclease in MCF‐7 cells

2001 • 48 citations

Quantification of Active Caspase 3 in Apoptotic Cells

2000 • 46 citations

Bacterial cupredoxin azurin and its interactions with the tumor suppressor protein p53

2003 • 45 citations

Redox proteins in mammalian cell death: an evolutionarily conserved function in mitochondria and prokaryotes

2003 • 43 citations

Heregulin-induced apoptosis is mediated by down-regulation of Bcl-2 and activation of caspase-7 and is potentiated by impairment of protein kinase C α activity

2001 • 41 citations

Tumor apoptosis induced by epoxide-containing piperazines, a new class of anti-cancer agents

2000 • 32 citations

Keeping the immune system alerted against cancer

1998 • 23 citations

Expression, proteolysis and activation of caspases 6 and 7 during rat C6 glioma cell apoptosis

2002 • 21 citations

Delayed type hypersensitivity response to recall antigens does not accurately reflect immune competence in advanced stage breast cancer patients

2002 • 17 citations

Analysis of a Mitochondrial Apoptotic Pathway Using Bid-Targeted Ribozymes in Human MCF7 Cells in the Absence of a Caspase-3-Dependent Pathway

2003 • 14 citations

Bacterial battalions join war against cancer

2003 • 13 citations