Bcl-XL Protects BimEL-induced Bax Conformational Change and Cytochrome c Release Independent of Interacting with Bax or BimEL

Mitochondria and Apoptosis

1998 • 8,909 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

The expanding role of mitochondria in apoptosis.

2001 • 2,377 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

Mitochondria as the central control point of apoptosis

2000 • 1,875 citations

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

1997 • 1,805 citations

Endonuclease G is an apoptotic DNase when released from mitochondria

2001 • 1,725 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues

2000 • 1,427 citations

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

1999 • 1,255 citations

A matter of life and death

2002 • 1,251 citations

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

1998 • 1,183 citations

p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53

2000 • 1,155 citations

Bim: a novel member of the Bcl-2 family that promotes apoptosis

1998 • 1,154 citations

Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane

2000 • 1,150 citations

Cytosol-to-membrane redistribution of Bax and Bcl-X_Lduring apoptosis

1997 • 1,117 citations

A Serine Protease, HtrA2, Is Released from the Mitochondria and Interacts with XIAP, Inducing Cell Death

2001 • 1,106 citations

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1998 • 1,100 citations

Structure of Bax

2000 • 1,066 citations

The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex

1999 • 1,045 citations

BH3-Only Proteins—Essential Initiators of Apoptotic Cell Death

2000 • 1,033 citations

Caspase Cleaved BID Targets Mitochondria and Is Required for Cytochrome c Release, while BCL-XL Prevents This Release but Not Tumor Necrosis Factor-R1/Fas Death

1999 • 1,024 citations

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

2000 • 983 citations

Breaking the mitochondrial barrier

2001 • 947 citations

BID: a novel BH3 domain-only death agonist.

1996 • 921 citations

Anti-cancer activity of targeted pro-apoptotic peptides

1999 • 904 citations

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

2001 • 815 citations

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

2002 • 772 citations

Identification of Omi/HtrA2 as a Mitochondrial Apoptotic Serine Protease That Disrupts Inhibitor of Apoptosis Protein-Caspase Interaction

2002 • 732 citations

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

2002 • 699 citations

Bax Is Present as a High Molecular Weight Oligomer/Complex in the Mitochondrial Membrane of Apoptotic Cells

2001 • 676 citations

Cytochrome c Release and Apoptosis Induced by Mitochondrial Targeting of Nuclear Orphan Receptor TR3

2000 • 651 citations

Molecular Cloning and Characterization of Bif-1

2001 • 637 citations

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

2000 • 619 citations

Regulated Targeting of BAX to Mitochondria

1998 • 617 citations

Nonionic Detergents Induce Dimerization among Members of the Bcl-2 Family

1997 • 583 citations

Dominant-Negative c-Jun Promotes Neuronal Survival by Reducing BIM Expression and Inhibiting Mitochondrial Cytochrome c Release

2001 • 568 citations

HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins

2002 • 550 citations

The Serine Protease Omi/HtrA2 Regulates Apoptosis by Binding XIAP through a Reaper-like Motif

2002 • 533 citations

Bax-independent inhibition of apoptosis by Bcl-XL

1996 • 484 citations

Pathways of Apoptosis in Lymphocyte Development, Homeostasis, and Disease

2002 • 482 citations

Bax and Bak Coalesce into Novel Mitochondria-Associated Clusters during Apoptosis

2001 • 466 citations

Cardiolipin provides specificity for targeting of tBid to mitochondria

2000 • 462 citations

Induction of BIM, a Proapoptotic BH3-Only BCL-2 Family Member, Is Critical for Neuronal Apoptosis

2001 • 453 citations

BAX-dependent transport of cytochrome c reconstituted in pure liposomes

2000 • 447 citations

Mitochondrial endonuclease G is important for apoptosis in C. elegans

2001 • 416 citations

BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death

2000 • 415 citations

The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change

2001 • 390 citations

Essential Role of Voltage-Dependent Anion Channel in Various Forms of Apoptosis in Mammalian Cells

2001 • 360 citations

Direct Activation of Mitochondrial Apoptosis Machinery by c-Jun N-terminal Kinase in Adult Cardiac Myocytes

2002 • 342 citations

Apoptosis-regulating proteins as targets for drug discovery

2001 • 327 citations

Bcl-2 Prevents Bax Oligomerization in the Mitochondrial Outer Membrane

2001 • 320 citations

Identification of Novel Isoforms of the BH3 Domain Protein Bim Which Directly Activate Bax To Trigger Apoptosis

2002 • 287 citations

Ceramide Induces Cytochrome c Release from Isolated Mitochondria

1999 • 273 citations

The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4

1998 • 237 citations

The Proapoptotic BH3-Only Protein Bim Is Expressed in Hematopoietic, Epithelial, Neuronal, and Germ Cells

2000 • 227 citations

Downregulation of Bim, a Proapoptotic Relative of Bcl-2, Is a Pivotal Step in Cytokine-Initiated Survival Signaling in Murine Hematopoietic Progenitors

2001 • 210 citations

The pro-apoptotic Bcl-2 family member tBid localizes to mitochondrial contact sites.

2001 • 141 citations

Bid, a Widely Expressed Proapoptotic Protein of the Bcl-2 Family, Displays Lipid Transfer Activity

2001 • 130 citations

The Destabilization of Lipid Membranes Induced by the C-terminal Fragment of Caspase 8-cleaved Bid Is Inhibited by the N-terminal Fragment

2000 • 126 citations

Bcl-2 Inhibits a Fas-induced Conformational Change in the Bax N Terminus and Bax Mitochondrial Translocation

2000 • 121 citations

BID-dependent and BID-independent pathways for BAX insertion into mitochondria

2000 • 108 citations

Epothilone B analogue (BMS-247550)-mediated cytotoxicity through induction of Bax conformational change in human breast cancer cells.

2002 • 99 citations

Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl‐2 family¹

2001 • 91 citations

Mitochondrial Lipid Alterations during Fas- and Radiation-Induced Apoptosis

2001 • 69 citations

Mechanisms of Bcl-2 protein function.

1998 • 62 citations

The BH3 domain of BAD fused to the Antennapedia peptide induces apoptosis via its alpha helical structure and independent of Bcl-2

2001 • 60 citations

Targeting and insertion of C-terminally anchored proteins to the mitochondrial outer membrane is specific and saturable but does not strictly require ATP or molecular chaperones

2000 • 31 citations

Leakage and aggregation of phospholipid vesicles induced by the BH3‐only Bcl‐2 family member, BID

2001 • 29 citations

Targeting and insertion of C-terminally anchored proteins to the mitochondrial outer membrane is specific and saturable but does not strictly require ATP or molecular chaperones

2000 • 23 citations