Induction of BIM, a Proapoptotic BH3-Only BCL-2 Family Member, Is Critical for Neuronal Apoptosis

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

1995 • 1,500 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Apoptosis Signaling

2000 • 1,290 citations

Bim: a novel member of the Bcl-2 family that promotes apoptosis

1998 • 1,154 citations

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

1999 • 1,102 citations

The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex

1999 • 1,045 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.

1994 • 820 citations

A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death

1995 • 800 citations

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

1991 • 800 citations

BAX Is Required for Neuronal Death after Trophic Factor Deprivation and during Development

1996 • 745 citations

The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9

1998 • 628 citations

Phosphatidylinositol 3-Kinase and Akt Protein Kinase Are Necessary and Sufficient for the Survival of Nerve Growth Factor-Dependent Sympathetic Neurons

1998 • 577 citations

Analysis of cell cycle-related gene expression in postmitotic neurons: Selective induction of cyclin D1 during programmed cell death

1994 • 576 citations

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor.

1993 • 535 citations

Widespread elimination of naturally occurring neuronal death in Bax-deficient mice.

1998 • 412 citations

Inhibitors of protein synthesis

1974 • 411 citations

Role of Ca2+ channels in the ability of membrane depolarization to prevent neuronal death induced by trophic-factor deprivation: evidence that levels of internal Ca2+ determine nerve growth factor dependence of sympathetic ganglion cells.

1989 • 405 citations

Bax Deletion Further Orders the Cell Death Pathway in Cerebellar Granule Cells and Suggests a Caspase-independent Pathway to Cell Death

1997 • 390 citations

harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-XL

1997 • 381 citations

Widespread Elimination of Naturally Occurring Neuronal Death inBax-Deficient Mice

1998 • 348 citations

Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: Evidence for the role of cell death genes

1990 • 332 citations

Caspases – controlling intracellular signals by protease zymogen activation

2000 • 329 citations

BAX Translocation Is a Critical Event in Neuronal Apoptosis: Regulation by Neuroprotectants, BCL-2, and Caspases

1999 • 314 citations

cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor.

1988 • 312 citations

The Release of Cytochrome c from Mitochondria during Apoptosis of NGF-deprived Sympathetic Neurons Is a Reversible Event

1999 • 297 citations

Insulin-Like Growth Factor and Potassium Depolarization Maintain Neuronal Survival by Distinct Pathways: Possible Involvement of PI 3-Kinase in IGF-1 Signaling

1997 • 294 citations

Motoneuron Apoptosis Is Blocked by CEP-1347 (KT 7515), a Novel Inhibitor of the JNK Signaling Pathway

1998 • 291 citations

Role of the Jun Kinase Pathway in the Regulation of c-Jun Expression and Apoptosis in Sympathetic Neurons

1998 • 284 citations

Evidence of a Novel Event during Neuronal Death

1998 • 276 citations

The effects of nerve growth factor and its antiserum on the postnatal development and survival after injury of sensory neurons in rat dorsal root ganglia

1984 • 265 citations

Depolarization and Neurotrophins Converge on the Phosphatidylinositol 3-Kinase–Akt Pathway to Synergistically Regulate Neuronal Survival

1999 • 253 citations

Inhibition of Phosphatidylinositol 3-Kinase Activity Blocks Depolarization- and Insulin-like Growth Factor I-mediated Survival of Cerebellar Granule Cells

1997 • 246 citations

Activated Phosphatidylinositol 3-Kinase and Akt Kinase Promote Survival of Superior Cervical Neurons

1997 • 245 citations

Translocation of C. elegans CED-4 to Nuclear Membranes During Programmed Cell Death

2000 • 236 citations

Spatially and Functionally Distinct Roles of the PI3-K Effector Pathway during NGF Signaling in Sympathetic Neurons

2000 • 229 citations

The Proapoptotic BH3-Only Protein Bim Is Expressed in Hematopoietic, Epithelial, Neuronal, and Germ Cells

2000 • 227 citations

Nerve growth factor regulates sympathetic ganglion cell morphology and survival in the adult mouse

1990 • 227 citations

Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases.

1996 • 223 citations

Metabolic and Genetic Analyses of Apoptosis in Potassium/Serum-Deprived Rat Cerebellar Granule Cells

1996 • 216 citations

The Death Programme in Cultured Sympathetic Neurones Can Be Suppressed at the Posttranslational Level by Nerve Growth Factor, Cyclic AMP, and Depolarization

1991 • 202 citations

CEP‐1347 (KT7515), an Inhibitor of JNK Activation, Rescues Sympathetic Neurons and Neuronally Differentiated PC12 Cells from Death Evoked by three Distinct Insults

1999 • 192 citations

The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation.

1996 • 190 citations

Caspase Inhibition Extends the Commitment to Neuronal Death Beyond Cytochrome c Release to the Point of Mitochondrial Depolarization

2000 • 183 citations

Chronic depolarization prevents programmed death of sympathetic neurons in vitro but does not support growth: requirement for Ca2+ influx but not Trk activation

1995 • 171 citations

Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice.

1997 • 166 citations

Blocking Cytochrome c Activity within Intact Neurons Inhibits Apoptosis

1998 • 161 citations

Molecular Cloning of a Novel Polypeptide, DP5, Induced during Programmed Neuronal Death

1997 • 158 citations

Ras Regulates Sympathetic Neuron Survival by Suppressing the p53-Mediated Cell Death Pathway

1999 • 150 citations

baxDeficiency Prevents the Increased Cell Death of Immature Neurons inbcl-x-Deficient Mice

1997 • 143 citations

Analysis of the Mechanism of Loss of Trophic Factor Dependence Associated with Neuronal Maturation: A Phenotype Indistinguishable fromBaxDeletion

1997 • 123 citations

Comparison Between the Timing of JNK activation, c‐Jun Phosphorylation, and Onset of Death Commitment in Sympathetic Neurones

1997 • 100 citations

[20] Techniques in the tissue culture of rat sympathetic neurons

1983 • 86 citations

Placement of the BCL2 Family Member BAX in the Death Pathway of Sympathetic Neurons Activated by Trophic Factor Deprivation

1998 • 82 citations

Expression of the SM‐20 Gene Promotes Death in Nerve Growth Factor‐Dependent Sympathetic Neurons

1999 • 77 citations

Inhibition of Apoptotic Signaling Cascades Causes Loss of Trophic Factor Dependence during Neuronal Maturation

2000 • 73 citations

Staurosporine-induced neuronal death: multiple mechanisms and methodological implications

2000 • 67 citations

Involvement of caspases in sympathetic neuron apoptosis

1997 • 66 citations

Why do neurons die when deprived of trophic factor?

1989 • 57 citations

Phosphatidylinositol 3-Kinase Is Required for the Trophic, But Not the Survival-Promoting, Actions of NGF on Sympathetic Neurons

2000 • 43 citations

Rapid Hybridoma Screening Method for the Identification of Monoclonal Antibodies to Low-Abundance Cytoplasmic Proteins

1998 • 40 citations

Trophic support promotes survival of bcl-x-deficient telencephalic cells in vitro

1998 • 39 citations