A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

1977 • 5,640 citations

A catalogue of splice junction sequences

1982 • 3,861 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes

1981 • 1,265 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

SH2 and SH3 domains: From structure to function

1992 • 977 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

SH2-Containing Phosphotyrosine Phosphatase as a Target of Protein-Tyrosine Kinases

1993 • 666 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

1990 • 561 citations

Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.

1994 • 525 citations

Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses

1983 • 518 citations

Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex.

1993 • 510 citations

Src homology region 2 domains direct protein-protein interactions in signal transduction.

1990 • 498 citations

A Noncatalytic Domain Conserved among Cytoplasmic Protein-Tyrosine Kinases Modifies the Kinase Function and Transforming Activity of Fujinami Sarcoma Virus P130^gag-fps

1986 • 478 citations

Binding of Transforming Protein, P47 ^gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

1990 • 433 citations

Binding of GAP to Activated PDGF Receptors

1990 • 396 citations

Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

1992 • 361 citations

Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library

1993 • 361 citations

Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine.

1988 • 351 citations

Rat cell line 3y1 and its virogenic polyoma‐ and SV40‐transformed derivatives

1975 • 340 citations

Antiphosphotyrosine Recovery of Phospholipase C Activity After EGF Treatment of A-431 Cells

1988 • 324 citations

Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates

1992 • 306 citations

Two species of human CRK cDNA encode proteins with distinct biological activities.

1992 • 269 citations

Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts.

1993 • 257 citations

The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110.

1991 • 224 citations

Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3

1990 • 209 citations

Platelet-Derived Growth Factor (PDGF)-Dependent Association of Phospholipase C-γ with the PDGF Receptor Signaling Complex

1990 • 204 citations

Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity.

1990 • 191 citations

Solution structure and ligand-binding site of the SH3 domain of the p85α subunit of phosphatidylinositol 3-kinase

1993 • 185 citations

The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors.

1992 • 174 citations

Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries.

1992 • 168 citations

Construction and Characterization of a Retroviral Vector Demonstrating Efficient Expression of Cloned cDNA Sequences

1988 • 157 citations

The product of the cellular crk gene consists primarily of SH2 and SH3 regions.

1992 • 147 citations

Mutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformation

1990 • 128 citations

Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins.

1991 • 127 citations

Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrate.

1993 • 125 citations

Tyrosine-phosphorylated epidermal growth factor receptor and cellular p130 provide high affinity binding substrates to analyze Crk-phosphotyrosine-dependent interactions in vitro.

1992 • 120 citations

Stable association of pp60^src and pp59^fyn with the focal adhesion-associated protein tyrosine kinase, pp125^FAK

1994 • 119 citations

Binding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides.

1993 • 115 citations

Activation of c-Src in cells bearing v-Crk and its suppression by Csk.

1992 • 99 citations

Phosphorylation of Nek in Response to a Variety of Receptors, Phorbol Myristate Acetate, and Cyclic AMP

1992 • 94 citations

Mutations in src homology regions 2 and 3 of activated chicken c-src that result in preferential transformation of mouse or chicken cells.

1990 • 93 citations

The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment.

1992 • 88 citations

Closing in on SH2 specificity

1993 • 86 citations

A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction.

1992 • 78 citations

Identification and Characterization of a High-Affinity Interaction Between v-Crk and Tyrosine-Phosphorylated Paxillin in CT10-Transformed Fibroblasts

1993 • 71 citations

Two Species of Human CRK cDNA Encode Proteins with Distinct Biological Activities

1992 • 58 citations

Multiple SH2-mediated interactions in v-src-transformed cells.

1992 • 53 citations

Binding of the Src SH2 Domain to Phosphopeptides is Determined by Residues in both the SH2 Domain and the Phosphopeptides

1993 • 42 citations

A newly isolated avian sarcoma virus, ASV-1, carries the crk oncogene.

1989 • 40 citations

Structural requirement of CRK SH2 region for binding to phosphotyrosine-containing proteins. Evidence from reactivity to monoclonal antibodies.

1993 • 33 citations

Identification and Sequence Analysis of cDNAs Encoding a 110-Kilodalton Actin Filament-Associated pp60^src Substrate

1993 • 30 citations

Identification of Domains of the v-crk Oncogene Product Sufficient for Association with Phosphotyrosine-Containing Proteins

1991 • 30 citations

Activation of c-Src in Cells Bearing v-Crk and Its Suppression by Csk

1992 • 29 citations

The SH2 and SH3 Domain-Containing Nek Protein Is Oncogenic and a Common Target for Phosphorylation by Different Surface Receptors

1992 • 29 citations

A Limited Set of SH2 Domains Binds BCR through a High- Affinity Phosphotyrosine-Independent Interaction

1992 • 28 citations

Differential association of cellular proteins with family protein-tyrosine kinases.

1991 • 25 citations

The SH2/SH3 Domain-Containing Protein Nck Is Recognized by Certain Anti-Phospholipase C-γl Monoclonal Antibodies, And Its Phosphorylation on Tyrosine Is Stimulated by Platelet-Derived Growth Factor and Epidermal Growth Factor Treatment

1992 • 16 citations

Identification of novel protein-tyrosine phosphatases in a human leukemia cell line, F-36P.

1993 • 12 citations

A simple method for immunoaffinity purification of nondenatured avian sarcoma and leukemia virus gag-containing proteins

1987 • 10 citations

Multiple SH2-Mediated Interactions In v-src-Transformed Cells

1992 • 10 citations