Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

1999 • 2,051 citations

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1995 • 2,028 citations

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1998 • 1,786 citations

A causal role for E-cadherin in the transition from adenoma to carcinoma

1998 • 1,415 citations

The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.

1989 • 1,393 citations

Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo

1996 • 1,013 citations

Skeletal and CNS Defects in Presenilin-1-Deficient Mice

1997 • 953 citations

Cell binding function of E-cadherin is regulated by the cytoplasmic domain.

1988 • 811 citations

Regulation of Cadherin Adhesive Activity

2000 • 793 citations

Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex.

1995 • 739 citations

Cadherin superfamily genes: functions, genomic organization, and neurologic diversity

2000 • 640 citations

Assembly of the cadherin-catenin complex in vitro with recombinant proteins

1994 • 557 citations

Selective Uncoupling of P120ctn from E-Cadherin Disrupts Strong Adhesion

2000 • 456 citations

Neuroplasticity Failure in Alzheimer's Disease

1999 • 442 citations

Transmembrane control of cadherin-mediated cell adhesion: a 94 kDa protein functionally associated with a specific region of the cytoplasmic domain of E-cadherin.

1989 • 436 citations

The p120 catenin family: Complex roles in adhesion, signaling and cancer

2000 • 427 citations

Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain

1992 • 394 citations

Differential molecular interactions of β-catenin and plakoglobin in adhesion, signaling and cancer

1998 • 343 citations

Genetic and biochemical dissection of protein linkages in the cadherin-catenin complex.

1995 • 341 citations

A Role for the Cadherin Family of Cell Adhesion Molecules in Hippocampal Long-Term Potentiation

1998 • 336 citations

Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells.

1994 • 326 citations

Molecular Modification of N-Cadherin in Response to Synaptic Activity

2000 • 306 citations

Differential Localization of VE- and N-Cadherins in Human Endothelial Cells: VE-Cadherin Competes with N-Cadherin for Junctional Localization

1998 • 297 citations

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1997 • 289 citations

Cadherin Function Is Required for Axon Outgrowth in Retinal Ganglion Cells In Vivo

1996 • 280 citations

Alzheimer's disease: a re-examination of the amyloid hypothesis

1998 • 256 citations

Presenilin-1 Forms Complexes with the Cadherin/Catenin Cell–Cell Adhesion System and Is Recruited to Intercellular and Synaptic Contacts

1999 • 221 citations

The Membrane-proximal Region of the E-Cadherin Cytoplasmic Domain Prevents Dimerization and Negatively Regulates Adhesion Activity

1998 • 173 citations

p120ctn Binds to the Membrane-proximal Region of the E-cadherin Cytoplasmic Domain and Is Involved in Modulation of Adhesion Activity

1999 • 171 citations

E-cadherin mediates adhesion and suppresses cell motility via distinct mechanisms

1997 • 165 citations

Direct association of presenilin‐1 with β‐catenin

1998 • 159 citations

Presenilins Interact with Armadillo Proteins Including Neural‐Specific Plakophilin‐Related Protein and β‐Catenin

1999 • 110 citations

Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains

1996 • 91 citations

Secreted Glypican Binds to the Amyloid Precursor Protein of Alzheimer's Disease (APP) and Inhibits APP-induced Neurite Outgrowth

1996 • 89 citations

Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains

1996 • 69 citations

Presenilin-1-immunoreactive neurons are preserved in late-onset Alzheimer's disease.

1997 • 53 citations

Appican Expression Induces Morphological Changes in C6 Glioma Cells and Promotes Adhesion of Neural Cells to the Extracellular Matrix

1997 • 43 citations

AIDS: A Justifiable Share

1997 • 22 citations

Loss of presenilin 1 leads to epidermal hyperplasia and tumorigenesis in adult mice

2000 • 2 citations