The Morphogenetic Role of Cadherin Cell Adhesion Molecules in Human Cancer: A Thematic Review

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator

1991 • 3,314 citations

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC ^−/− Colon Carcinoma

1997 • 3,234 citations

Functional interaction of β-catenin with the transcription factor LEF-1

1996 • 2,847 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

1991 • 1,686 citations

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.

1991 • 1,592 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

Tumor Cell Interactions with the Extracellular Matrix During Invasion and Metastasis

1993 • 1,523 citations

Morphogenetic roles of classic cadherins

1995 • 1,468 citations

The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.

1989 • 1,393 citations

Hereditary cancer, oncogenes, and antioncogenes.

1985 • 1,261 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

1997 • 1,215 citations

Association of the APC Tumor Suppressor Protein with Catenins

1993 • 1,202 citations

Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF

1997 • 1,201 citations

Structural basis of cell-cell adhesion by cadherins

1995 • 1,173 citations

Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness

1994 • 1,018 citations

Cadherins in cancer: implications for invasion and metastasis

1993 • 939 citations

TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors.

1994 • 937 citations

E-cadherin null mutant embryos fail to form a trophectoderm epithelium.

1994 • 920 citations

Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene.

1993 • 912 citations

Cell binding function of E-cadherin is regulated by the cytoplasmic domain.

1988 • 811 citations

The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex.

1988 • 810 citations

Wnt genes

1992 • 799 citations

E-cadherin gene mutations provide clues to diffuse type gastric carcinomas.

1994 • 772 citations

E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.

1995 • 763 citations

Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex.

1995 • 739 citations

Structural basis of calcium-induced E-cadherin rigidification and dimerization

1996 • 688 citations

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells.

1996 • 680 citations

Expressed recombinant cadherins mediate cell sorting in model systems

1988 • 673 citations

Inflammatory Bowel Disease and Adenomas in Mice Expressing a Dominant Negative N-Cadherin

1995 • 672 citations

Overexpression of cadherins and underexpression of ?-catenin inhibit dorsal mesoderm induction in early Xenopus embryos

1994 • 647 citations

Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas.

1995 • 635 citations

Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high-grade prostate cancer.

1992 • 612 citations

Experimental specification of cell sorting, tissue spreading, and specific spatial patterning by quantitative differences in cadherin expression.

1994 • 580 citations

Identification of a neural α-catenin as a key regulator of cadherin function and multicellular organization

1992 • 562 citations

Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling.

1995 • 545 citations

E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis.

1991 • 536 citations

Adhesion in cell migration

1995 • 520 citations

Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes.

1994 • 490 citations

E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain.

1996 • 466 citations

Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas.

1993 • 457 citations

LEF-1, a Nuclear Factor Coordinating Signaling Inputs from wingless and decapentaplegic

1997 • 450 citations

Tyrosine Phosphorylation of β-Catenin and Plakoglobin Enhanced by Hepatocyte Growth Factor and Epidermal Growth Factor in Human Carcinoma Cells

1994 • 421 citations

p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system.

1993 • 421 citations

In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death.

1995 • 416 citations

Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line.

1994 • 405 citations

Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin

1994 • 405 citations

Signal transduction by β-catenin

1995 • 398 citations

Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain

1992 • 394 citations

Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus.

1996 • 322 citations

Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo.

1995 • 313 citations

Lateral dimerization is required for the homophilic binding activity of C-cadherin.

1996 • 307 citations

Conformational changes of the recombinant extracellular domain of E‐cadherin upon calcium binding

1994 • 303 citations

E-cadherin expression in colorectal cancer. An immunocytochemical and in situ hybridization study.

1993 • 297 citations

Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes.

1995 • 290 citations

E-cadherin gene mutations in human gastric carcinomacell lines.

1994 • 288 citations

A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines.

1994 • 284 citations

Mutations of the E–cadherin gene in human gynecologic cancers

1994 • 280 citations

Expression and distribution of cell adhesion molecule uvomorulin in mouse preimplantation embryos

1987 • 271 citations

E-cadherin and alpha-catenin expression in human esophageal cancer.

1994 • 253 citations

Soluble 80‐kd fragment of cell‐CAM 120/80 disrupts cell‐cell adhesion

1987 • 239 citations

Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion

1992 • 236 citations

Cell Contact-Dependent Signaling

1996 • 225 citations

Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation

1994 • 223 citations

Purification of a 92-kDa cytoplasmic protein tightly associated with the cell-cell adhesion molecule E-cadherin (uvomorulin)

1991 • 208 citations

Induction of a secondary body axis in Xenopus by antibodies to beta-catenin.

1993 • 205 citations

Integrin-mediated adhesion and signaling in tumorigenesis

1994 • 203 citations

E-cadherin expression in human breast cancer cells suppresses the development of osteolytic bone metastases in an experimental metastasis model.

1996 • 193 citations

Inhibition of cultured cell growth by vascular endothelial cadherin (cadherin-5/VE-cadherin).

1996 • 187 citations

E-cadherin: a differentiation marker in thyroid malignancies.

1993 • 172 citations

The estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctions.

1996 • 162 citations

Regulation of C-cadherin function during activin induced morphogenesis of Xenopus animal caps.

1994 • 156 citations

Ectopic expression of N-cadherin perturbs histogenesis in Xenopus embryos

1990 • 152 citations

No evidence for mutations in the alpha- and beta-catenin genes in human gastric and breast carcinomas.

1996 • 109 citations

Regulation of E-cadherin-mediated adhesion by muscarinic acetylcholine receptors in small cell lung carcinoma.

1993 • 91 citations

Role of E-cadherin in the response of tumor cell aggregates to lymphatic, venous and arterial flow: measurement of cell-cell adhesion strength

1995 • 84 citations

E-cadherin expression in primary and metastatic thoracic neoplasms and in Barrett's oesophagus

1995 • 81 citations

Poorly Differentiated Colon Carcinoma Cell Lines Deficient in α-Catenin Expression Express High Levels of Surface E-cadherin but Lack Ca²⁺-Dependent Cell-Cell Adhesion

1993 • 80 citations

Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells: Possible involvement of plakoglobin

1993 • 69 citations

Enlarged cell-associated proteoglycans abolish E-cadherin functionality in invasive tumor cells.

1994 • 57 citations

Regulation of the cell-cell adhesion protein, E-cadherin, in dog and human thyrocytes in vitro.

1995 • 47 citations

Cadherin Transfection of Xenopus XTC Cells Downregulates Expression of Substrate Adhesion Molecules

1995 • 44 citations

Intracellular domain of desmoglein 3 (pemphigus vulgaris antigen) confers adhesive function on the extracellular domain of E-cadherin without binding catenins.

1995 • 29 citations