Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex

THE UBIQUITIN SYSTEM

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An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

Functional interaction of β-catenin with the transcription factor LEF-1

1996 • 2,847 citations

Morphogenetic roles of classic cadherins

1995 • 1,468 citations

A Multiubiquitin Chain Is Confined to Specific Lysine in a Targeted Short-Lived Protein

1989 • 1,463 citations

A causal role for E-cadherin in the transition from adenoma to carcinoma

1998 • 1,415 citations

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

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The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

1999 • 1,045 citations

Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness

1994 • 1,018 citations

Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1

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Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion.

1989 • 961 citations

E-cadherin null mutant embryos fail to form a trophectoderm epithelium.

1994 • 920 citations

Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene.

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Regulation of Cadherin Adhesive Activity

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A 26 S protease subunit that binds ubiquitin conjugates.

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Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells.

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Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

1996 • 572 citations

Recycling of E-Cadherin

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A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development.

1995 • 498 citations

Gettin’ down with ubiquitin: turning off cell-surface receptors, transporters and channels

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Selective Uncoupling of P120ctn from E-Cadherin Disrupts Strong Adhesion

2000 • 456 citations

p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system.

1993 • 421 citations

The roles of catenins in the cadherin-mediated cell adhesion: functional analysis of E-cadherin-alpha catenin fusion molecules.

1994 • 398 citations

Ubiquitin Lys63 is involved in ubiquitination of a yeast plasma membrane protein

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A Function for Monoubiquitination in the Internalization of a G Protein–Coupled Receptor

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Coupling of Gab1 to C-Met, Grb2, and Shp2 Mediates Biological Responses

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Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated.

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Activation of the Protein Kinase Akt/PKB by the Formation of E-cadherin-mediated Cell-Cell Junctions

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Classical cadherins

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SHP2 Association with VE-Cadherin Complexes in Human Endothelial Cells Is Regulated by Thrombin

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Regulation of cell movement: the motogenic cytokines

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Coendocytosis of cadherin and c-Met coupled to disruption of cell-cell adhesion in MDCK cells – regulation by Rho, Rac and Rab small G proteins

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The ubiquitin-proteasome system and endocytosis

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Ubiquitination of the yeast a-factor receptor.

1996 • 172 citations

c-Cbl Is Transiently Tyrosine-phosphorylated, Ubiquitinated, and Membrane-targeted following CSF-1 Stimulation of Macrophages

1996 • 163 citations

Cloning of Human Ubiquitin-conjugating Enzymes UbcH6 and UbcH7 (E2-F1) and Characterization of Their Interaction with E6-AP and RSP5

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The deubiquitinating enzyme Fam interacts with and stabilizes β‐catenin

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Catabolite inactivation of the galactose transporter in the yeast Saccharomyces cerevisiae: ubiquitination, endocytosis, and degradation in the vacuole

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Expression of novel DNA-binding protein with zinc finger structure in various tumor cells.

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Phosphotyrosine-modified proteins are concentrated at the membranes of epithelial and endothelial cells during tissue development in chick embryos.

1988 • 84 citations

Interaction of the Adaptor Protein Shc and the Adhesion Molecule Cadherin

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Cell-Cell Dissociation upon Epithelial Cell Scattering Requires a Step Mediated by the Proteasome

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Modification of the E-cadherin-Catenin Complex in Mitotic Madin-Darby Canine Kidney Epithelial Cells

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Heat shock induces protein tyrosine phosphorylation in cultured cells.

1989 • 39 citations